2021
DOI: 10.1091/mbc.e20-12-0807
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Cdk1 phosphorylation of fission yeast paxillin inhibits its cytokinetic ring localization

Abstract: Divisions of the genetic material and cytoplasm are coordinated spatially and temporally to ensure genome integrity. This coordination is mediated in part by the major cell cycle regulator cyclin-dependent kinase (Cdk1). Cdk1 activity peaks during mitosis, but during mitotic exit/cytokinesis Cdk1 activity is reduced, and phosphorylation of its substrates is reversed by various phosphatases including Cdc14, PP1, PP2A and PP2B. Cdk1 is known to phosphorylate several components of the actin- and myosin-based cyto… Show more

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Cited by 1 publication
(1 citation statement)
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“…The F-BAR domain protein CDC15 plays important roles in the assembly of the contractile ring in the fission yeast Schizosaccharomyces pombe [ 54 ]. CDC15-mediated contractile ring assembly involves a sequence of events including dephosphorylation of the hyperphosphorylated state at interphase, binding to formin CDC12, localization to the site of cytokinesis, recruitment of Myo1 (class II myosin heavy chain), and activation of the Arp2/3 complex to promote actin cable network formation [ 53 , 55 , 56 , 57 , 58 , 59 , 60 , 61 , 62 , 63 , 64 , 65 ].…”
Section: Lipid Shapes Asymmetric Distribution Lateral Organization An...mentioning
confidence: 99%
“…The F-BAR domain protein CDC15 plays important roles in the assembly of the contractile ring in the fission yeast Schizosaccharomyces pombe [ 54 ]. CDC15-mediated contractile ring assembly involves a sequence of events including dephosphorylation of the hyperphosphorylated state at interphase, binding to formin CDC12, localization to the site of cytokinesis, recruitment of Myo1 (class II myosin heavy chain), and activation of the Arp2/3 complex to promote actin cable network formation [ 53 , 55 , 56 , 57 , 58 , 59 , 60 , 61 , 62 , 63 , 64 , 65 ].…”
Section: Lipid Shapes Asymmetric Distribution Lateral Organization An...mentioning
confidence: 99%