In this paper, we proposed a regularized particle filter (RPF) algorithm for multi-user detection (MUD) in synchronous code division multiple access (CDMA) system. It is especially suitable for non-linear non-Gaussian system. In the standard particle filter algorithm. If particles weights have vast difference, we needed to re-sampling, but it replicates particles with larger weights and discards particles with small weights, so that it will lose the diversity of particles. Regularized particle filter algorithm can effectively overcome this shortcoming.