cDNA microarray analysis assists in diagnosis of malignant intrarenal pheochromocytoma originally masquerading as a renal cell carcinoma

Does ‘granular cell’ renal cell carcinoma exist? Molecular and histological reclassification

“…Ten years after its initial diagnosis as a granular cell RCC and multiple failed surgical attempts to control pelvic metastases, this patient's treatment plan was revised by discontinuing his chemotherapy designed for RCC and instituting radiation therapy, resulting in a marked decrease in tumour burden after the first month of the new treatment. 4 Our findings are also supported by those of Higgins et al, who performed cDNA microarray analysis with- out histological review on five conventional 'granular cell' carcinomas among 41 renal tumours. Three of the five had molecular profiles that clustered with chromophobe RCC, one with papillary RCC and one with angiomyolipoma.…”

Gene Expression Profiling Identifies MMP-12 and ADAMDEC1 as Potential Pathogenic Mediators of Pulmonary Sarcoidosis

“…This approach has been applied to diseases of unknown cause to create new hypotheses relating to disease pathogenesis (7,8) and is shown to have prognostic (9) and diagnostic applications (10,11).…”

Malignant paraganglioma arising from the kidney

“…The main source of this confusion is the use of the term "pheochromocytoma" for any catecholamine-secreting paraganglioma, i.e., extraadrenal pheochromocytoma. A search of the literature revealed 5 reported cases of intrarenal paraganglioma 1 and 6 reported cases of intrarenal pheochromocytoma up to 2005, 2, 3 We could not accurately diagnose the present case due to a lack of symptoms of catecholamine excess. Five of the 11 reported cases involved clinical manifestations of catecholamine hypersecretion, 1-3 while the remaining cases did not.…”