cDNA sequence of cattle MHC class I genes transcribed in serologically defined haplotypes A18 and A31

Ellis, Shirley A.; Staines, Karen; Morrison, W. Ivan

doi:10.1007/bf00176677

Cited by 35 publications

(21 citation statements)

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“…Furthermore, although A1 and C1 are nonpolymorphic both these genes, along with E1, B3 (from group D), and five group B sequences (B2, B3, B4, 8 and 9, 1-29) were previously shown to have higher rates of nonsynonymous than synonymous substitution in the peptide binding region, indicating that they may all function to present peptide to T cells (Ellis et al 1995). Finally, while both A1 and C1 have the threonine-to-serine amino acid replacement at position 143 in the ␣ 2 domain, thought to be a marker of nonclassical class I genes, this change is also present in a number of classical class I sequences from cattle (Ellis et al 1996) and so may not be diagnostic of gene function or origin in all species. The status of A1 and C1 are therefore ambiguous, apparently being both nonpolymorphic yet with classical class I features and, so, do not appear to fulfill the standard criteria for either class Ia or class Ib genes (Hughes et al 1999).…”

Section: Discussionmentioning

confidence: 99%

Evolutionary History of MHC Class I Genes in the Mammalian Order Perissodactyla

Holmes

Ellis

1999

J Mol Evol

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We carried out an analysis of partial sequences from expressed major histocompatibility complex (MHC) class I genes isolated from a range of equid species and more distantly related members of the mammalian order Perissodactyla. Phylogenetic analysis revealed a minimum of six groups, five of which contained genes and alleles that are found in equid species and one group specific to the rhinoceros. Four of the groups contained only one, or very few sequences, indicating the presence of relatively nonpolymorphic loci, while another group contained the majority of the equid sequences identified. These data suggest that a diversification of MHC genes took place after the split between the Equidae and the Rhinocerotidae yet before the speciation events within the genus Equus.

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Section: Discussionmentioning

confidence: 99%

Evolutionary History of MHC Class I Genes in the Mammalian Order Perissodactyla

Holmes

Ellis

1999

J Mol Evol

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“…One bull was A18/A18, the other A31/A31. All animals were bred at the Institute for Animal Health [23].…”

Section: Methodsmentioning

confidence: 99%

Vaccination of neonatal calves withMycobacterium bovisBCG induces protection against intranasal challenge with virulentM. bovis

Hope

Thom

Villarreal‐Ramos

et al. 2004

Clinical and Experimental Immunology

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SummaryVaccination of neonates with Mycobacterium bovis bacillus Calmette-Guérin (BCG) may be a strategy that overcomes reduced vaccine efficacy associated with exposure to environmental mycobacteria in humans and cattle. Preliminary comparisons indicated that 2-week-old calves produced an immune response to vaccination at least as intense as that observed in adults. Subsequently, five gnotobiotic hysterotomy derived calves aged 1 day were inoculated with BCG and 3 months later were challenged intranasally with virulent M. bovis . The number of tissues with lesions and the pathological extent of these lesions was reduced significantly in vaccinates. Furthermore, lesions were evident in the lung or associated chest lymph nodes of four of five controls but none of five vaccinates. BCG vaccination reduced significantly the level of bacterial colonization. However, lesions in the head associated lymph nodes were observed in three of five BCG-vaccinated cattle. Levels of interferon gamma (IFN-g g g g ) detected by enzyme-linked immunosorbent assay (ELISA) or enzyme-linked immunospot (ELISPOT) in individual vaccinated animals at challenge did not correlate with subsequent resistance and in general immune responses post-challenge were lower in vaccinated calves. Low IL-10 responses were evident but IL-4 was not detected. Responses to ESAT-6 and/or CFP-10 were evident in four of four control calves that had lesions. Two of the BCG vaccinates with lesions did not produce a response to ESAT-6 and CFP-10, indicating that these antigens did not distinguish vaccinated immune animals from vaccinated animals with lesions. Overall, vaccination of neonatal calves with BCG induced significant protection against disease and has potential as a strategy for the reduction of the incidence of bovine tuberculosis.

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“…For the vaccination study, Holstein-Friesian cattle (Bos taurus) were vaccinated intramuscularly with one bovine dose of either serotype O or serotype A inactivated vaccine (Merial, Pirbright, United Kingdom) and boosted 11 weeks later. All of the animals used in this study (Table 1) were from a partially inbred herd, in which MHC class I haplotypes have been characterized at the level of expressed genes (16,17). Details of cattle MHC haplotypes, alleles, and nomenclature can be found at the website www.ebi.ac.uk/ipd/mhc/bola/.…”

Section: Viruses and Vaccinesmentioning

confidence: 99%

Induction of a Cross-Reactive CD8⁺T Cell Response following Foot-and-Mouth Disease Virus Vaccination

Guzman

Taylor

Charleston

et al. 2010

J Virol

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cDNA sequence of cattle MHC class I genes transcribed in serologically defined haplotypes A18 and A31

Cited by 35 publications

References 8 publications

Evolutionary History of MHC Class I Genes in the Mammalian Order Perissodactyla

Evolutionary History of MHC Class I Genes in the Mammalian Order Perissodactyla

Vaccination of neonatal calves withMycobacterium bovisBCG induces protection against intranasal challenge with virulentM. bovis

Induction of a Cross-Reactive CD8⁺T Cell Response following Foot-and-Mouth Disease Virus Vaccination

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cDNA sequence of cattle MHC class I genes transcribed in serologically defined haplotypes A18 and A31

Cited by 35 publications

References 8 publications

Evolutionary History of MHC Class I Genes in the Mammalian Order Perissodactyla

Evolutionary History of MHC Class I Genes in the Mammalian Order Perissodactyla

Vaccination of neonatal calves withMycobacterium bovisBCG induces protection against intranasal challenge with virulentM. bovis

Induction of a Cross-Reactive CD8+T Cell Response following Foot-and-Mouth Disease Virus Vaccination

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Induction of a Cross-Reactive CD8⁺T Cell Response following Foot-and-Mouth Disease Virus Vaccination