CdO nanoparticles, c‐MWCNT nanoparticles and CdO nanoparticles/c‐MWCNT nanocomposite fibres: in vitro assessment of anti‐proliferative and apoptotic studies in HeLa cancer cell line

The Application of Carbon Nanomaterials in Sensing, Imaging, Drug Delivery and Therapy for Gynecologic Cancers: An Overview

“…Recently, they further found that the combination of rGO-AgNPs and trichostatin A (TSA) can cause potential cytotoxicity and induce significantly greater cell death compared to either rGO-Ag alone or TSA alone in ovarian cells by various mechanisms including reactive oxygen species generation, mitochondrial dysfunction, and DNA damage [ 99 ]. Saranya et al compared the anti-proliferative and apoptotic ability of CdO NPs, multiwalled carbon nanotube (c-MWCNT) NPs, and CdO/c-MWCNT nanocomposites, and CdO/c-MWCNT nanohybrids were found to have scavenging anti-cancer potential when compared with c-MWCNT NPs and CdO NP-based nanosystems [ 100 ]. The above results indicate that the coupling of carbon nanomaterials with other nanoparticles (e.g., metals and metal oxides) and drugs for combination therapy will be most effective when different nanoparticles and drugs with different action mechanisms are combined.…”

“…Despite these achievements, clinical trials are still very scarce but are vitally important for the real application of carbon nanomaterials in gynecological cancers. Moreover, it is worth noting that some carbon-based nanohybrids such as rGO–Ag and CdO/c-MWCNT have good anticancer effects [ 98 , 99 , 100 ], which seem to be contradictory to many other similar carbon-based systems claimed with low toxicity and good biocompatibility [ 111 , 112 , 113 , 114 , 115 ]. The biosecurity of these carbon-based nanomedicines still should be investigated more carefully for their real application in the human body.…”