CDP-choline modulates matrix metalloproteinases in rat sciatic injury

GÜNDOĞDU, Elif BAŞARAN; Bekâr, Ahmet; Turkyilmaz, Mesut; Gümüş, Abdullah; Kafa, İ̇lker Mustafa; Cansev, Mehmet

doi:10.1016/j.jss.2015.10.003

Cited by 18 publications

(11 citation statements)

References 37 publications

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“…The total number of myelinated axons in the citicoline group was 75%, 183%, and 146% greater on days 1, 3, and 7, respectively ( p < 0.001). The influence of citicoline on the level of metalloproteinases may explain its beneficial effect in the regeneration of damaged peripheral nerves [ 70 ].…”

Section: Resultsmentioning

confidence: 99%

Application of Citicoline in Neurological Disorders: A Systematic Review

et al. 2020

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Citicoline is a chemical compound involved in the synthesis of cell membranes. It also has other, not yet explained functions. Research on the use of citicoline is conducted in neurology, ophthalmology, and psychiatry. Citicoline is widely available as a dietary supplement. It is often used to enhance cognitive functions. In our article, accessible databases were searched for articles regarding citicoline use in neurological diseases. This article has a systemic review form. After rejecting non-eligible reports, 47 remaining articles were reviewed. The review found that citicoline has been proven to be a useful compound in preventing dementia progression. It also enhances cognitive functions among healthy individuals and improves prognosis after stroke. In an animal model of nerve damage and neuropathy, citicoline stimulated regeneration and lessened pain. Among patients who underwent brain trauma, citicoline has an unclear clinical effect. Citicoline has a wide range of effects and could be an essential substance in the treatment of many neurological diseases. Its positive impact on learning and cognitive functions among the healthy population is also worth noting.

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Section: Resultsmentioning

confidence: 99%

Application of Citicoline in Neurological Disorders: A Systematic Review

et al. 2020

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“…CDP-choline is critical in establishing and maintaining cell membrane structure and protecting neurons during hypoxic and ischemic conditions [ 38 ]. Six articles addressed the role of cytidine 5’-diphosphocholine after PNI, all of which were conducted in a rat model [ 37 , 39 - 43 ]. CDP-choline administration resulted in decreased scar formation and nerve adherence to surrounding tissue, improved sciatic nerve functional recovery, increased amplitude of the muscle action potential, axonal organization, axonal counts, axonal density, and axonal myelination following PNI [ 37 , 39 - 43 ], and reduced neuropathic pain [ 42 ].…”

Section: Reviewmentioning

confidence: 99%

The Impact of Supplements on Recovery After Peripheral Nerve Injury: A Review of the Literature

Abushukur¹,

Knackstedt²

2022

Cureus

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Peripheral nerve injury (PNI) can result from trauma, surgical resection, iatrogenic injury, and/or local anesthetic toxicity. Damage to peripheral nerves may result in debilitating weakness, numbness, paresthesia, pain, and/or autonomic instability. As PNI is associated with inflammation and nerve degeneration, means to mitigate this response could result in improved outcomes. Numerous nutrients have been investigated to prevent the negative sequelae of PNI. Alpha-lipoic acid, cytidine diphosphate-choline (CDP Choline), curcumin, melatonin, vitamin B12, and vitamin E have demonstrated notable success in improving recovery following PNI within animal models. While animal studies show ample evidence that various supplements may improve recovery after PNI, similar evidence in human patients is limited. The goal of this review is to analyze supplements that have been used successfully in animal models of PNI to serve as a reference for future studies on human patients. By analyzing supplements that have shown efficacy in animal studies, healthcare providers will have a resource from which to guide decision-making regarding future human studies investigating the role that supplements could play in PNI recovery. Ultimately, establishing a comprehensive understanding of these supplements in human patients following PNI may significantly improve post-surgical outcomes, quality of life, and peripheral nerve regeneration.

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“…However, excessive destruction inhibits regeneration itself because there will be damage to the blood-neuron barrier that triggers macrophage and neutrophil infiltration. TIMP-1 and TIMP-3 are important proteins that protect from excessive destruction by indirectly binding to MMP [22,23].…”

Section: Pathology Of Painful Diabetic Polyneuropathy Evidence Of Citicoline Effectiveness On Peripheral Nerve Lesion and Their Suggestedmentioning

confidence: 99%

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2021

Ro J Neurol.

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The purpose of this paper is to review the effectiveness of citicoline as suggested adjuvant therapy for painful diabetic polyneuropathy based on evidences. Pain is one of the most common symptoms that make patients consult with a doctor, especially chronic pain. One of the examples is painful diabetic polyneuropathy, which prevalence is increasing by global development. Diabetic polyneuropathy is the most common cause of neuropathic pain caused by long-term complications of microangiopathy. Affect not only individual socioeconomic status but also the psychological aspect of the patient. Neuropathic pain is one of the most common causes of long-term disability. Some medicines already recommended as the drug of choice, but not all of them give maximum results. Adjuvant neuroprotector therapy is often considered to help manage painful diabetic polyneuropathy, such as citicoline, which has been proven in some studies. Painful diabetic polyneuropathy is very challenging because of its pathophysiology, which has not fully understood. The different mechanism of pain sensation is still unknown but it is thought that the oxidative stress after microangiopathy triggers the discharge of abnormal load from damaged neurons. Some analgetics have not given the expected result. Conclusion.Citicoline may be suggested as adjuvant therapy based on evidences with animal subject, but further studies with human subject are still needed.

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CDP-choline modulates matrix metalloproteinases in rat sciatic injury

Cited by 18 publications

References 37 publications

Application of Citicoline in Neurological Disorders: A Systematic Review

Application of Citicoline in Neurological Disorders: A Systematic Review

The Impact of Supplements on Recovery After Peripheral Nerve Injury: A Review of the Literature

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