CDs assembled metal-organic framework: Exogenous coreactant-free biosensing platform with pore confinement-enhanced electrochemiluminescence

Tao, Xiuli; Pan, Mei-Chen; Yang, Xia; Yuan, Ruo; Zhuo, Ying

doi:10.1016/j.cclet.2022.01.010

Cited by 38 publications

(17 citation statements)

References 18 publications

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“…As shown in Figure , the peaks at 397 and 286 eV might correspond to N 1s and C 1s, respectively. This was consistent with literature, indicating the presence of N and C elements. − Moreover, the peaks at 82 and 86 eV confirmed the presence of the Au element. , These results demonstrated the successful preparation of Au NPs@g-C 3 N 4 .…”

Section: Resultssupporting

confidence: 91%

Au NP-Decorated g-C₃N₄-Based Photoelectochemical Biosensor for Sensitive Mercury Ions Analysis

et al. 2022

ACS Omega

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Herein, an efficient and feasible photoelectrochemical (PEC) biosensor based on gold nanoparticle-decorated graphitic-like carbon nitride (Au NPs@g-C 3 N 4 ) with excellent photoelectric performance was designed for the highly sensitive detection of mercury ions (Hg 2+ ) . The proposed Au NPs@g-C 3 N 4 was first modified on the surface of the electrode, which possessed a remarkable photocurrent conversion efficiency and could produce a strong initial photocurrent. Then, the thymine-rich DNA (S1) was immobilized on the surface of the modified electrode via Au–N bonds. Subsequently, 1-hexanethiol (HT) was added to the resultant electrode to block nonspecific binding sites. Finally, the target Hg 2+ was incubated on the surface of the modified glassy carbon electrode (GCE). In the presence of target Hg 2+ , the thymine–Hg 2+ –thymine (T-Hg 2+ -T) structure formed due to the selective capture capability of thymine base pairs toward Hg 2+ , resulting in the significantly decrease of the photocurrent. Thereafter, the proposed PEC biosensor was successfully used for sensitive Hg 2+ detection, as it possessed a wide linear range from 1 pM to 1000 nM with a low detection limit of 0.33 pM. Importantly, this study demonstrates a new method of detecting Hg 2+ and provides a promising platform for the detection of other heavy metal ions of interest.

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Section: Resultssupporting

confidence: 91%

Au NP-Decorated g-C₃N₄-Based Photoelectochemical Biosensor for Sensitive Mercury Ions Analysis

et al. 2022

ACS Omega

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“…Apparently, the MnO x S y NFs had amazing promoting performance toward the S 2 O 8 2– solution, making the ECL intensity of MnO x S y NFs/GCE (curve b in Figure D) 5.2 times stronger than that of bare GCE in the S 2 O 8 2– solution (curve a in Figure D). It could be attributed to the rich defect and hierarchical structures of MnO x S y NFs, which not only fully exposed active sites to adsorb and activate abundant reactants in a confined solution microenvironment, but also changed charge distribution and produced much more highly active catalytic sites to make the electrochemical reaction easier by sulfur doping. − …”

Section: Resultsmentioning

confidence: 99%

Identifying 5-Hydroxymethylcytosine without Sequence Specificity Using MOF-Derived MnO_xS_y Nanoflowers for Boosting Electrochemiluminescence

et al. 2022

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It is universally recognized that the quantification of DNA hydroxymethylation at random gene sequences still remains challenging. Herein, the highly sensitive identifying strategy of 5-hydroxymethylcytosine (5-hmC) without sequence specificity was achieved with a novel electrochemiluminescence (ECL) biosensor, which deftly integrated metal–organic framework (MOF)-derived amorphous MnO x S y nanoflowers (MnO x S y NFs) as a bifunctional co-reaction accelerator and cross-shaped DNA tracks as a well-regulated signal switch. Specifically, the target recognition process of 5-hmC was performed through specific chemical modification, where the hydroxymethyl sites were first aminated and then labeled with a 5′-carboxyl-functioned DNA walker, thus forming the target labeled DNA walker (5-ghmC-walker). Subsequently, the cross-shaped DNA tracks were ingeniously designed to endow the 5-ghmC-walker with continuous mechanical motion due to the long periodic linear alignment structure and well-regulated highly ordered interfaces. Furthermore, as a bifunctional co-reaction accelerator synthesized by in situ Mn-MOF template-sacrificing strategy, the MnO x S y NFs could promote the reduction of both dissolved O2 and S2O8 2–, remarkably boosting the ECL intensity of a peroxydisulfate (S2O8 2–) solution by 5.2 times compared to the pure S2O8 2– solution. Benefiting from specific target recognition and a dual-pathway strategy for boosting ECL, the proposed ECL platform can quantify 5-hmC with a wide linear range of 1 fM–1 nM and a low detection limit of 0.29 fM. This simple, highly sensitive strategy without sequence specificity provides a powerful platform for 5-hmC detection in the epigenetic study and disease pathogenesis.

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“…As a new class of carbon-based nanomaterials, due to their simple preparation process, extremely small size, excellent optical properties, low toxicity, and excellent biocompatibility, − carbon dots (CDs) have been widely used in biological fields such as biosensing, , cell imaging, , drug delivery, and antibacterial ,, and tumor therapy. − Small-sized CDs have a large specific surface area and can more firmly bind to bacteria . Through electrostatic attraction, positively charged CDs can bind to the cell membrane of negatively charged bacteria, destroy the cell membrane of bacteria, and leak their cytoplasmic components, eventually leading to bacterial death and achieving better antibacterial performance .…”

Section: Introductionmentioning

confidence: 99%

Positively Charged Carbon Dots with Antibacterial and Antioxidant Dual Activities for Promoting Infected Wound Healing

Gao

et al. 2023

ACS Appl. Mater. Interfaces

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Bacterial infection and excess reactive oxygen species are key factors that lead to slow or substantially delayed wound healing. It is crucial to design and develop new nanomaterials with antibacterial and antioxidative capabilities for wound healing. Here, positively charged carbon dots (CDs) are rationally designed and synthesized from p-phenylenediamine and polyethyleneimine by a facile one-pot solvothermal method, which show good biocompatibility in in vitro cytotoxicity, hemolysis assays, and in vivo toxicity evaluation. The positively charged CDs show superior antimicrobial effect against Staphylococcus aureus (S. aureus) at very low concentrations, reducing the risk of wound infection. At the same time, CDs with surface defects and unpaired electrons can effectively scavenge excess free radicals to reduce oxidative stress damage, accelerate wound inflammation−proliferation transition, and promote wound healing. The mouse model of skin infection demonstrates that CDs can effectively promote the wound healing of skin infection without obvious side effects by simply dropping or spraying onto the wound. We believe that the prepared CDs have satisfactory biocompatibility, antioxidant capacity, and excellent antibacterial activity and have great application potential in wound healing.

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CDs assembled metal-organic framework: Exogenous coreactant-free biosensing platform with pore confinement-enhanced electrochemiluminescence

Cited by 38 publications

References 18 publications

Au NP-Decorated g-C₃N₄-Based Photoelectochemical Biosensor for Sensitive Mercury Ions Analysis

Au NP-Decorated g-C₃N₄-Based Photoelectochemical Biosensor for Sensitive Mercury Ions Analysis

Identifying 5-Hydroxymethylcytosine without Sequence Specificity Using MOF-Derived MnO_xS_y Nanoflowers for Boosting Electrochemiluminescence

Positively Charged Carbon Dots with Antibacterial and Antioxidant Dual Activities for Promoting Infected Wound Healing

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CDs assembled metal-organic framework: Exogenous coreactant-free biosensing platform with pore confinement-enhanced electrochemiluminescence

Cited by 38 publications

References 18 publications

Au NP-Decorated g-C3N4-Based Photoelectochemical Biosensor for Sensitive Mercury Ions Analysis

Au NP-Decorated g-C3N4-Based Photoelectochemical Biosensor for Sensitive Mercury Ions Analysis

Identifying 5-Hydroxymethylcytosine without Sequence Specificity Using MOF-Derived MnOxSy Nanoflowers for Boosting Electrochemiluminescence

Positively Charged Carbon Dots with Antibacterial and Antioxidant Dual Activities for Promoting Infected Wound Healing

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Product

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Au NP-Decorated g-C₃N₄-Based Photoelectochemical Biosensor for Sensitive Mercury Ions Analysis

Au NP-Decorated g-C₃N₄-Based Photoelectochemical Biosensor for Sensitive Mercury Ions Analysis

Identifying 5-Hydroxymethylcytosine without Sequence Specificity Using MOF-Derived MnO_xS_y Nanoflowers for Boosting Electrochemiluminescence