CdS/MoS 2 heterojunction-based photoelectrochemical DNA biosensor via enhanced chemiluminescence excitation

Zang, Yang; Lei, Jianping; Hao, Qing; Ju, Huangxian

doi:10.1016/j.bios.2015.10.010

Cited by 109 publications

(38 citation statements)

References 53 publications

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“…Therefore, photoactive materials are crucial for the performance of the PEC sensors. Many photoactive materials are metal-contained semiconductors, such as TiO 2 , CdSe, CdTe, ZnO, ZnS, etc 1 2 3 4 5 6 7 8 9 . Among them, titanium dioxide is one of the most commonly employed materials because of its nontoxicity, low-cost and brilliant photochemical and chemical stability.…”

mentioning

confidence: 99%

Photoelectrochemical Immunosensor for Detection of Carcinoembryonic Antigen Based on 2D TiO2 Nanosheets and Carboxylated Graphitic Carbon Nitride

Wang

Zhang

et al. 2016

Sci Rep

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Carcinoembryonic antigen (CEA) was used as the model, an ultrasensitive label-free photoelectrochemical immunosensor was developed using 2D TiO2 nanosheets and carboxylated graphitic carbon nitride (g-C3N4) as photoactive materials and ascorbic acid as an efficient electron donor. 2D TiO2 nanosheets was sythsized by surfactant self-assembly method and proved to have higher photoelectrochemical signals than TiO2 nanoparticles. Firstly, carboxylated g-C3N4 could be attached to 2D TiO2 nanosheets through the bond formed between carboxyl group of carboxylated g-C3N4 and TiO2. And the photocurrent of g-C3N4/TiO2 drastically enhances compared to carboxylated g-C3N4 and TiO2. Then, antibody of CEA was bonded to TiO2 through the dentate bond formed between carboxyl group of anti-CEA and TiO2, leading to the decrease of the photocurrents. As proven by PEC experiments and electrochemical impedance spectroscopy (EIS) analysis, the fabrication process of the immunosensor is successful. Under the optimal conditions, the intensity decreased linearly with CEA concentration in the range of 0.01~10 ng/mL. The detection limit is 2.1 pg/mL. The work provides an effective method for the detection of tumor markers and can be extended for the application in food safety and environmental monitoring analysis.

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mentioning

confidence: 99%

Photoelectrochemical Immunosensor for Detection of Carcinoembryonic Antigen Based on 2D TiO2 Nanosheets and Carboxylated Graphitic Carbon Nitride

Wang

Zhang

et al. 2016

Sci Rep

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“…In addition, the signals can be dynamically monitored . Many researchers have attempted to construct a DNA sensing strategy by labeling reporters (fluorophore, electroactive indicator) onto the hairpins . The corresponding signals can be collected by following the progress of the system reaction.…”

Section: Cha Based Biosensors For Various Targetsmentioning

confidence: 99%

Applications of Catalytic Hairpin Assembly Reaction in Biosensing

Liu

Zhang

Xie

et al. 2019

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Nucleic acids are considered as perfect programmable materials for cascade signal amplification and not merely as genetic information carriers. Among them, catalytic hairpin assembly (CHA), an enzyme‐free, high‐efficiency, and isothermal amplification method, is a typical example. A typical CHA reaction is initiated by single‐stranded analytes, and substrate hairpins are successively opened, resulting in thermodynamically stable duplexes. CHA circuits, which were first proposed in 2008, present dozens of systems today. Through in‐depth research on mechanisms, the CHA circuits have been continuously enriched with diverse reaction systems and improved analytical performance. After a short time, the CHA reaction can realize exponential amplification under isothermal conditions. Under certain conditions, the CHA reaction can even achieve 600 000‐fold signal amplification. Owing to its promising versatility, CHA is able to be applied for analysis of various markers in vitro and in living cells. Also, CHA is integrated with nanomaterials and other molecular biotechnologies to produce diverse readouts. Herein, the varied CHA mechanisms, hairpin designs, and reaction conditions are introduced in detail. Additionally, biosensors based on CHA are presented. Finally, challenges and the outlook of CHA development are considered.

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“…Firstly, long ssDNA obtain from dsDNA samples through the combined action of nicking enzyme and polymerase (Jia et al, 2010;Qian et al, 2012;Nie et al, 2015;Shi et al, 2016). Then, hairpin self-assembly trigger recycling happen in the presence of ssDNA (Yin et al, 2008;Wu et al, 2015;Zang et al, 2016). In this catalytic process, the long ssDNA acts on kinetically trapped substrates via exposed toehold and strand exchange reaction with hairpin structure, refolding the substrate and allowing them to interact with one another (Jung and Ellington, 2014).…”

Section: Introductionmentioning

confidence: 98%

An electrochemical biosensor for double-stranded Wnt7B gene detection based on enzymatic isothermal amplification

Chen

et al. 2016

Biosensors and Bioelectronics

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CdS/MoS 2 heterojunction-based photoelectrochemical DNA biosensor via enhanced chemiluminescence excitation

Cited by 109 publications

References 53 publications

Photoelectrochemical Immunosensor for Detection of Carcinoembryonic Antigen Based on 2D TiO2 Nanosheets and Carboxylated Graphitic Carbon Nitride

Photoelectrochemical Immunosensor for Detection of Carcinoembryonic Antigen Based on 2D TiO2 Nanosheets and Carboxylated Graphitic Carbon Nitride

Applications of Catalytic Hairpin Assembly Reaction in Biosensing

An electrochemical biosensor for double-stranded Wnt7B gene detection based on enzymatic isothermal amplification

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