CdTe compact gamma camera for coded aperture imaging in radioguided surgery

Russo, Paolo; Lillo, Francesca Di; Corvino, Veronica; Frallicciardi, P.M.; Sarno, Antonio; Mettivier, Giovanni

doi:10.1016/j.ejmp.2019.12.024

Cited by 17 publications

(26 citation statements)

References 69 publications

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“…Mainly four methods for real-time capable image reconstruction have been proposed within the last few decades. MURA Decoding (also called inverse filtering, or cross-correlation analysis): [3,4,6,18,20,21,30,31,47,48,54], Wiener Filtering [24,34], convolutional Maximum Likelihood Expectation Maximization (MLEM) reconstruction [38,39] and data-driven Deep Learning approaches [34,56,57]. Although the standard MLEM algorithm has also been investigated [28,36], it is not considered in this paper, because its reconstruction time of several hours makes it impractical for the application in mobile systems.…”

Section: Reconstruction Methodsmentioning

confidence: 99%

“…This approach contains a-priori knowledge and seeks to answers the question "Where is the source located?". For instance, when a coded aperture 𝛾-camera is applied to the task of sentinel lymph node mapping, like several groups intend [18,30,31,47], the radiating sources can be considered to be of spherical shape with maximally a few centimeters in diameter. A set of training data could be generated for this specific task.…”

Section: Dual Image Reconstructionmentioning

confidence: 99%

“…CAI has been investigated as alternative collimator in single photon emission computed tomography (SPECT): Experiments for imaging the bio-distribution of radioactively labeled compounds in small animals, have been carried out [4,6]. [18,30,47] analyzed the use of a coded aperture 𝛾-camera for the localization of sentinel lymph nodes and [38,39] examined the capability of imaging coldspot lesions in cardiac imaging. Other research fields like x-ray fluorescence spectroscopy [34] or nuclear decommissioning [15,21] analyzed the potential use of CAI as well.…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Quantitative Comparison of Planar Coded Aperture Imaging Reconstruction Methods

Meißner¹,

Rozhkov²,

Hesser³

et al. 2022

Preprint

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Section: Reconstruction Methodsmentioning

confidence: 99%

Section: Dual Image Reconstructionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Quantitative Comparison of Planar Coded Aperture Imaging Reconstruction Methods

Meißner¹,

Rozhkov²,

Hesser³

et al. 2022

Preprint

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“…Refs. [7,22,23] analyzed the use of a coded aperture 𝛾-camera for the localization of sentinel lymph nodes and [24,25] examined the capability of imaging cold-spot lesions in cardiac imaging. Other research fields like x-ray fluorescence spectroscopy [14] or nuclear decommissioning [9,11] analyzed the potential use of CAI as well.…”

Section: Introductionmentioning

confidence: 99%

Quantitative comparison of planar coded aperture imaging reconstruction methods

Meißner¹,

Rozhkov²,

Hesser³

et al. 2023

J. Inst.

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Imaging distributions of radioactive sources plays a substantial role in nuclear medicine as well as in monitoring nuclear waste and its deposit. Coded Aperture Imaging (CAI) has been proposed as an alternative to parallel or pinhole collimators, but requires image reconstruction as an extra step. Multiple reconstruction methods with varying run time and computational complexity have been proposed. Yet, no quantitative comparison between the different reconstruction methods has been carried out so far. This paper focuses on a comparison based on three sets of hot-rod phantom images captured with an experimental γ-camera consisting of a Tungsten-based MURA mask with a 2 mm thick 256 × 256 pixelated CdTe semiconductor detector coupled to a Timepix© readout circuit. Analytical reconstruction methods, MURA Decoding, Wiener Filter and a convolutional Maximum Likelihood Expectation Maximization (MLEM) algorithm were compared to data-driven Convolutional Encoder-Decoder (CED) approaches. The comparison is based on the contrast-to-noise ratio as it has been previously used to assess reconstruction quality. For the given set-up, MURA Decoding, the most commonly used CAI reconstruction method, provides robust reconstructions despite the assumption of a linear model. For single image reconstruction, however, MLEM performed best of all analytical reconstruction methods, but took on average 45 times longer than MURA Decoding. The fastest reconstruction method is the Wiener Filter with a run time 4.3 times faster compared to MURA Decoding and a mediocre quality. The CED with a specifically tailored training set was able to succeed the most commonly used MURA decoding on average by a factor between 1.37 and 2.60 and an equal run time.

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“…This can provide real-time three dimensional information about the surgical field (Heuveling et al 2015) but requires a continuous line of sight to the external optical tracker and can be operator-dependent (Pouw 2016). Coded aperture mask imaging (which requires a post-imaging deconvolution) is an active area of research and has shown promise particularly for lower energy photons (Russo et al 2020).…”

Section: Introductionmentioning

confidence: 99%

Stereoscopic portable hybrid gamma imaging for source depth estimation

Bugby¹,

Lees²,

McKnight³

et al. 2021

Phys. Med. Biol.

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Advances in gamma imaging technology mean that is now technologically feasible to conduct stereoscopic gamma imaging in a hand-held unit. This paper derives an analytical model for stereoscopic pinhole imaging which can be used to predict performance for a wide range of camera configurations. Investigation of this concept through Monte Carlo and benchtop studies, for an example configuration, shows camera-source distance measurements with a mean deviation between calculated and actual distances of <5 mm for imaging distances of 50-250 mm. By combining this technique with stereoscopic optical imaging, we are then able to calculate the depth of a radioisotope source beneath a surface without any external positional tracking. This new hybrid technique has the potential to improve surgical localisation in procedures such as sentinel lymph node biopsy.

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CdTe compact gamma camera for coded aperture imaging in radioguided surgery

Cited by 17 publications

References 69 publications

Quantitative Comparison of Planar Coded Aperture Imaging Reconstruction Methods

Quantitative Comparison of Planar Coded Aperture Imaging Reconstruction Methods

Quantitative comparison of planar coded aperture imaging reconstruction methods

Stereoscopic portable hybrid gamma imaging for source depth estimation

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