2014
DOI: 10.1016/j.placenta.2014.04.011
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CDX1 restricts the invasion of HTR-8/SVneo trophoblast cells by inhibiting MMP-9 expression

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Cited by 29 publications
(21 citation statements)
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“…However, the underlining mechanisms of how NTE regulates the secretion and activity of MMP-9 require further study. Recent studies have reported that CDX1/2 restricts the invasion of HTR-8/SVneo trophoblast cells by inhibiting MMP-9 expression independently of the PI3K/AKT pathway [33, 34]. Our study showed that knockdown of NTE significantly decreased levels of phospho-Erk1/2 and phospho-AKT compared to control in HTR8/SVneo cells.…”
Section: Discussionsupporting
confidence: 58%
“…However, the underlining mechanisms of how NTE regulates the secretion and activity of MMP-9 require further study. Recent studies have reported that CDX1/2 restricts the invasion of HTR-8/SVneo trophoblast cells by inhibiting MMP-9 expression independently of the PI3K/AKT pathway [33, 34]. Our study showed that knockdown of NTE significantly decreased levels of phospho-Erk1/2 and phospho-AKT compared to control in HTR8/SVneo cells.…”
Section: Discussionsupporting
confidence: 58%
“…Among the various types of proteinases implicated in ECM degradation, MMPs are recognized as the major enzymes . As demonstrated in previous studies, activation of MMP‐9 promotes the migration and invasion not only in multiple tumor cells, but also in trophoblast cells . We have previously demonstrated that knockdown of LR1 can inhibit trophoblast cell invasion and migration, and reduced MMP‐2 and MMP‐9 activity .…”
Section: Discussionmentioning
confidence: 87%
“…30 As demonstrated in previous studies, activation of MMP-9 promotes the migration and invasion not only in multiple tumor cells, [31][32][33] but also in trophoblast cells. 34,35 We have previously demonstrated that knockdown of LR1 can inhibit trophoblast cell invasion and migration, and reduced MMP-2 and MMP-9 activity. 13 Consequently, the present study was conducted to explore whether LR1 was involved in the interaction between hypoxia and MMPs in JEG3 cells.…”
Section: Discussionmentioning
confidence: 99%
“…We have also investigated the roles of MMP-9 and TIMP-1 in trophoblast invasion. Previous reports have shown that CDX2 inhibits invasion of Lovo cells by reducing expression of MMP-2 [34] and CDX1 restricts the invasion of HTR-8/SVneo trophoblast cells by inhibiting MMP-9 expression [35]. So we investage the effects of CDX2 on MMP-9 and TIMP-1 expression.…”
Section: Discussionmentioning
confidence: 99%