2020
DOI: 10.1093/ajcp/aqaa161.128
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CDX2 Expression in Primary and Metastatic Prostatic Adenocarcinoma: A Retrospective Study

Abstract: Introduction/Objective CDX2 encodes a transcription factor expressed in the nuclei of intestinal epithelial cells. The CDX2 immunohistochemical stain has excellent diagnostic utility in the setting of carcinoma of unknown primary, especially in combination with cytokeratins 7 and 20. While the stain is fairly specific for intestinal origin, it is also expressed in tumors of other origins. Only rare case reports have described positivity for CDX2 in metastatic prostatic adenocarcinoma. Having … Show more

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“…according to Cowan et al (11), this marker is expressed in ~12% of patients diagnosed with lung cancer, and its expression can be variable. In the context of prostatic carcinoma, the utility and prevalence of CDX2 expression are not widely recognized or documented (12). the management of bone metastasis is an essential aspect of cancer care, particularly since the bone is a common site for metastasis for various primary tumors such as breast, prostate, lung, thyroid and kidney cancer (2).…”
Section: Discussionmentioning
confidence: 99%
“…according to Cowan et al (11), this marker is expressed in ~12% of patients diagnosed with lung cancer, and its expression can be variable. In the context of prostatic carcinoma, the utility and prevalence of CDX2 expression are not widely recognized or documented (12). the management of bone metastasis is an essential aspect of cancer care, particularly since the bone is a common site for metastasis for various primary tumors such as breast, prostate, lung, thyroid and kidney cancer (2).…”
Section: Discussionmentioning
confidence: 99%