CDX2 : un facteur à multiples facettes pour les cellules épithéliales du tube digestif

Boudreau, François; Rivard, Nathalie; Gendron, Fernand‐Pierre; Beaulieu, Jean‐François

doi:10.1051/medsci/20072317

Cited by 2 publications

(1 citation statement)

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“…Central to this is the stem cell niche, which includes a variety of soluble and insoluble mediators (Sailaja et al, 2016) such as those of the Wnt/β‐catenin and Notch pathways (Andersson‐Rolf et al, 2017; Spit et al, 2018; van der Heijden & Vermeulen, 2019) and components of the microenvironment such as the extracellular matrix molecules and their various cell receptors (Benoit, Groulx, et al, 2012; Cloutier et al, 2019). Collectively, these mediators drive the expression of specific transcription factors such as CDX2 (Boudreau et al, 2007) and modulate epigenetic mechanisms (Roostaee et al, 2016) that control cell proliferation and differentiation along the crypt‐villus axis.…”

Section: The Hippo Pathway In the Intestinementioning

confidence: 99%

Differential influence of YAP1 and TAZ on differentiation of intestinal epithelial cell: A review

Fallah

Beaulieu

2022

The Anatomical Record

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Intestinal cell stemness, proliferation and differentiation are complex processes all occurring in distinct compartments of the crypt that need to be closely regulated to ensure proper epithelial renewal. The involvement of the Hippo pathway in intestinal epithelial proliferation and regeneration after injury via the regulation of its effectors YAP1 and TAZ has been well-documented over the last decade. The implication of YAP1 and TAZ on intestinal epithelial cell differentiation is less clear. Using intestinal cell models in which the expression of YAP1 and TAZ can be modulated, our group showed that YAP1 inhibits differentiation of the two main intestinal epithelial cell types, goblet and absorptive cells through a specific mechanism involving the repression of prodifferentiation transcription factor CDX2 expression. Further analysis provided evidence that the repressive effect of YAP1 on intestinal differentiation is mediated by regulation of the Hippo pathway by Src family kinase activity. Interestingly, the TAZ paralog does not seem to be involved in this process, which provides another example of the lack of perfect complementarity of the two main Hippo effectors.

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