CDX4 regulates the progression of neural maturation in the spinal cord

Abstract

2 SUMMARY STATEMENTCdx4 is at the core of a gene regulatory network the coordinates the sequential transition of neural cell states during early spinal cord development, from pluripotency to early differentiation. ABSTRACTThe integration of extracellular signals by intracellular transcription factor networks is a critical determinant of cell fate decisions during embryonic development. In the vertebrate spinal cord, the progressive caudal-to-rostral maturation of neural progenitors (NPs)