CE Credit: Bone Marrow Transplantation: Immune System Suppression and Reconstitution

Alcoser, Pat Wills; Burchett, Sonya

doi:10.2307/3472145

Cited by 5 publications

(16 citation statements)

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“…Immune reconstitution can be defi ned as the recovery of antigen-specifi c T-cell function, production of cytokines, and cooperation with B lymphocytes in antibody productions (Alcoser & Burchett, 1999). Numerous transplant-related factors impact immune reconstitution.…”

Section: Immune Reconstitution: the Foundation For Safe Living After mentioning

confidence: 99%

“…The normal ratio of CD4+ helper T cells to CD8+ suppressor T cells is 2:1 (Alcoser & Burchett, 1999). Studies consistently have shown that levels of CD8+ T cells return to normal by day 100; however, CD4+ T lymphocytes do not return to normal until the second half of the fi rst year (Shenoy et al, 1999).…”

Section: Immune Recovery: Cellular Immunitymentioning

confidence: 99%

“…Serum immunoglobulins may return to normal by four months after transplantation but may be misleading because immunoglobulins are not always functional, especially when GVHD is present (Alcoser & Burchett, 1999). Defi ciency in B-lymphocyte function is recognized in the setting of chronic GVHD, which is thought to be the result of the immunosuppressive nature of GVHD process (Abrahamsen et al, 2005).…”

Section: Immune Recovery: Humoral Immunitymentioning

confidence: 99%

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Immune Reconstitution: The Foundation for Safe Living After an Allogeneic Hematopoietic Stem Cell Transplantation

Laffan¹,

Biedrzycki²

2006

Clinical Journal of Oncology Nursing

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With increasing frequency, oncology nurses are providing long-term care to hematopoietic stem cell transplantation (HSCT) recipients in nontransplantation settings. This may be a result of more patients receiving HSCTs, recipients living longer, and recipients' desire to return to their hometowns as soon as possible. Although critical to patients' initial recovery after HSCT, immune reconstitution also must remain a priority of oncology nursing care long beyond the date of discharge from a transplantation center. As patients resume their normal lives, oncology nurses need to be diligent in assessment and education to facilitate the ultimate goal, a safe life after HSCT. This article provides concise details about the short- and long-term immunologic effects of HSCT and focuses on the long-standing threat of opportunistic infections that can persist months and years after HSCT.

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Section: Immune Reconstitution: the Foundation For Safe Living After mentioning

confidence: 99%

Section: Immune Recovery: Cellular Immunitymentioning

confidence: 99%

Section: Immune Recovery: Humoral Immunitymentioning

confidence: 99%

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Immune Reconstitution: The Foundation for Safe Living After an Allogeneic Hematopoietic Stem Cell Transplantation

Laffan¹,

Biedrzycki²

2006

Clinical Journal of Oncology Nursing

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“…3 Formerly considered a treatment of last resort, SCT has become the curative therapy of choice for many malignancies that require high-dose chemotherapy or radiation, such as hematologic malignancies (leukemia, lymphomas, and multiple myeloma), advanced or resistant solid tumors, severe aplastic anemia, and selected immune deficiency disorders. 3,4 Stem-cell transplantation is an intensive procedure with many risks, and despite SCT, some patients will die from complications of transplant or from relapse of the original disease. 3,4 Despite the high risk and stressful nature of SCT, only 5 supportive care intervention studies were identified for this patient population.…”

mentioning

confidence: 99%

“…3,4 Stem-cell transplantation is an intensive procedure with many risks, and despite SCT, some patients will die from complications of transplant or from relapse of the original disease. 3,4 Despite the high risk and stressful nature of SCT, only 5 supportive care intervention studies were identified for this patient population. Three of the published studies targeted adults 5Y7 and 2 targeted adolescents.…”

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confidence: 99%

Exploring the Feasibility of a Therapeutic Music Video Intervention in Adolescents and Young Adults During Stem-Cell Transplantation

2009

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The purpose of this study was to explore the feasibility and preliminary efficacy of a therapeutic music video (TMV) intervention for adolescents and young adults (AYAs) undergoing stem-cell transplantation (SCT). Twelve AYAs (aged 11-24 years) were randomized to the TMV or an audio-book protocol. The TMV was designed to diminish symptom distress and improve coping, derived meaning, resilience, and quality of life by supporting AYAs in exploring thoughts and feelings. Six sessions with a board-certified music therapist were held twice a week for 3 weeks. The Adolescent Resilience Model guided the selection of a large, comprehensive battery of outcome measures. Major data collections occurred before admission, after intervention, and at 100 days after transplantation. Participants completed a brief set of measures at presession/postsessions 2, 4, and 6. Rates of consent, session completion, and questionnaire completion supported feasibility. Immediate follow-up measures suggest positive trends in the TMV group for hope, spirituality, confidence/mastery, and self-transcendence. Positive trends at 100 days include MOS, symptoms distress, defensive coping, spirituality, and self-transcendence. Therapeutic music video participants also demonstrated gains in quality of life. The TMV intervention may buffer the immediate after-effects of the stem-cell transplantation experience, and a larger study is warranted.

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Songwriting and Digital Video Production Interventions for Pediatric Patients Undergoing Bone Marrow Transplantation, Part I: An Analysis of Depression and Anxiety Levels According to Phase of Treatment

Robb

Ebberts

2003

J Pediatr Oncol Nurs

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Purposes of this exploratory case study were: (1) to examine how anxiety and depression levels vary with phase of bone marrow transplantation (BMT) and (2) to examine the effect of the proposed music therapy treatment protocol on anxiety and depression levels. Six pediatric BMT patients participated in the study. Three participants experienced the music condition and three participants experienced the no-music contact condition. Both conditions consisted of six, one-hour sessions that occurred over a three week period. The Children's Depression Inventory (CDI) was administered at the conclusion of each session to examine changes in depression levels across each phase of treatment. The State Trait Anxiety Inventory for Children (STAIC) served as a pre-/post-session measure of state anxiety. Graphic analysis of scores from the CDI and STAIC indicated a consistent trend in depression and anxiety levels according to phase of treatment for all participants. Four participants (3 music; 1 no-music) experienced decreased anxiety following a majority of sessions.

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CE Credit: Bone Marrow Transplantation: Immune System Suppression and Reconstitution

Cited by 5 publications

References 0 publications

Immune Reconstitution: The Foundation for Safe Living After an Allogeneic Hematopoietic Stem Cell Transplantation

Immune Reconstitution: The Foundation for Safe Living After an Allogeneic Hematopoietic Stem Cell Transplantation

Exploring the Feasibility of a Therapeutic Music Video Intervention in Adolescents and Young Adults During Stem-Cell Transplantation

Songwriting and Digital Video Production Interventions for Pediatric Patients Undergoing Bone Marrow Transplantation, Part I: An Analysis of Depression and Anxiety Levels According to Phase of Treatment

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