CE: Understanding the Complications of Sickle Cell Disease

Abstract

a These individuals contributed to the development of these guidelines during their tenure with the NHLBI Division for the Application of Research Discoveries. b These individuals contributed to the development of these guidelines during their tenure with American Institutes for Research (AIR).

Clinical outcomes of COVID-19 in patients with sickle cell disease and sickle cell trait: A critical appraisal of the literature

“…Repeated vaso-occlusive events may result in functional asplenia and immune deficiency in early childhood leading to life-long increased susceptibility to serious bacterial infections. Acute and chronic pain and other serious health conditions such as acute chest syndrome (ACS) and stroke [ 7 ] are also common in patients with SCD. SCD predominantly affects Black individuals.…”

Race Based Medicine, Colorblind Disease: How Racism in Medicine Harms Us All

“…Using race as a biological reality in medicine reinforces the misguided notion that other racial groups are genetically inferior to Whites, which is best illustrated by sickle cell. Sickle cell disease is labeled as a Black disease in medical guidelines, standards of care, and research (Adler and Rehkopf 2008;National Institutes of Health, 2002;Okwerekwu 2017;Solovieff et al 2011;Tanabe et al 2019). However, people from all different races (Asians, Whites, and Latinos) and places (Afghanistan, Bangladesh, Burma, Greece, Honduras, India, Indonesia, Italy, Spain, and Turkey) suffer from sickle cell (Bloom 1995;Wilkinson 1974).…”

A Systematic Review on the Management of Transfusion-Related Acute Lung Injury in Transfusion-Dependent Sickle Cell Disease

“…The condition causes the breakdown of red blood cells prematurely, resulting in anemia. Due to their deformed shape, sickle cells tend to become trapped within small vessels and deprive the tissues of blood that is rich in oxygen [ 2 ]. The onset of SCD is often accompanied by various complications, including hemolytic anemia, reduced immunity, inflammation, acute/chronic organ damage, and stroke, among others [ 3 ].…”