Ce6-Conjugated and polydopamine-coated gold nanostars with enhanced photoacoustic imaging and photothermal/photodynamic therapy to inhibit lung metastasis of breast cancer

Li, Ziwei; Yang, Fan; Wu, Di; Liu, Yanhong; Gao, Yang; Lian, Haichen; Zhang, Hongxin; Yin, Zhibin; Wu, Aiguo; Zeng, Leyong

doi:10.1039/d0nr05386d

Cited by 45 publications

(32 citation statements)

References 59 publications

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“…Moreover, combined PTT/PDT treatment was effective in the inhibition of lung metastasis, contrarily to PDT or PTT alone, where some lung metastasis was observed. Moreover, photoacoustic signals of tumours were observed after injection with Ce 6 -PDA@AuNSs, which emphasises its potential simultaneous application as a phototheranostic agent [86]. In another study, Zeng and co-workers [86] reported a Ce6-conjugated and polydopamine (PDA)-coated gold nanostars (AuNSs) for PTT/PDT and photoacoustic imaging.…”

Section: Targeted Therapy In Triple-negative Breast Cancermentioning

confidence: 95%

“…Moreover, photoacoustic signals of tumours were observed after injection with Ce 6 -PDA@AuNSs, which emphasises its potential simultaneous application as a phototheranostic agent [86]. In another study, Zeng and co-workers [86] reported a Ce6-conjugated and polydopamine (PDA)-coated gold nanostars (AuNSs) for PTT/PDT and photoacoustic imaging. The preparation of this material involved the deposit of PDA on the surface of AuNSs by dopamine self-polymerization, resulting in PDA@AuNSs.…”

Section: Targeted Therapy In Triple-negative Breast Cancermentioning

confidence: 95%

“…Moreover, in vivo experiments in a 4T1 tumour-bearing mice treated with Ce6-CuS/MSN@PDA@MnO2-FA NPs and combined therapy revealed that, after 14 days of treatment, the tumours almost disappeared due to nuclear shrinkage and cytoplasm leakage in apoptotic cells [85]. In another study, Zeng and co-workers [86] reported a Ce 6 -conjugated and polydopamine (PDA)-coated gold nanostars (AuNSs) for PTT/PDT and photoacoustic imaging. The preparation of this material involved the deposit of PDA on the surface of AuNSs by dopamine self-polymerization, resulting in PDA@AuNSs.…”

Section: Targeted Therapy In Triple-negative Breast Cancermentioning

confidence: 99%

“…Several classes of molecules, such as tetrapyrrolic macrocycles and analogues, including porphyrins [64][65][66][67][68][69][70][71], phthalocyanines [72,73], chlorins [22,23,[74][75][76][77][78][79][80][81][82][83][84][85][86], the prodrug 5-aminolevulinic acid (5-ALA) [87][88][89] and other dyes, such as adequately conjugated indocyanine green [90][91][92][93][94], have been explored as PS in TNBC targeted therapy. Chlorins and their analogues are very interesting molecules; besides their natural source and/or semi-synthetic preparation, these molecules exhibit good absorption in the therapeutic window (600-800 nm), which is an important feature for a good candidate for clinical PDT, due to the better light penetration in tissues (≈1-2 cm), which overcomes the light penetration limitation when other photosensitizers are used, such as porphyrins [48,49,95].…”

Section: Targeted Therapy In Triple-negative Breast Cancermentioning

confidence: 99%

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Current Photoactive Molecules for Targeted Therapy of Triple-Negative Breast Cancer

2021

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Cancer is the second leading cause of death worldwide; therefore, there is an urgent need to find safe and effective therapies. Triple-negative breast cancer (TNBC) is diagnosed in ca. 15–20% of BC and is extremely aggressive resulting in reduced survival rate, which is mainly due to the low therapeutic efficacy of available treatments. Photodynamic therapy (PDT) is an interesting therapeutic approach in the treatment of cancer; the photosensitizers with good absorption in the therapeutic window, combined with their specific targeting of cancer cells, have received particular interest. This review aims to revisit the latest developments on chlorin-based photoactive molecules for targeted therapy in TNBC. Photodynamic therapy, alone or combined with other therapies (such as chemotherapy or photothermal therapy), has potential to be a safe and a promising approach against TNBC.

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Section: Targeted Therapy In Triple-negative Breast Cancermentioning

confidence: 95%

Section: Targeted Therapy In Triple-negative Breast Cancermentioning

confidence: 95%

Section: Targeted Therapy In Triple-negative Breast Cancermentioning

confidence: 99%

Section: Targeted Therapy In Triple-negative Breast Cancermentioning

confidence: 99%

See 2 more Smart Citations

Current Photoactive Molecules for Targeted Therapy of Triple-Negative Breast Cancer

2021

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“…As one of the essentials in SDT, sonosensitizers have been explored in various tumor therapies [14]. Chlorine e6 (Ce6) was originally employed as a common photosensitizer, but its desirable therapeutic capability and excellent affinition to tumor tissue have made it capable of applying as a sonosensitizer as well [15]. Played as a second generation of chlorine family, Ce6 has aroused an extensive attention in tumor treatment for its desirable ROS generation [16].…”

Section: Introductionmentioning

confidence: 99%

Low-Intensity Focused Ultrasound-Augmented Multifunctional Nanoparticles for Integrating Ultrasound Imaging and Synergistic Therapy of Metastatic Breast Cancer

et al. 2021

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The metastasis of breast cancer is believed to have a negative effect on its prognosis. Benefiting from the remarkable deep-penetrating and noninvasive characteristics, sonodynamic therapy (SDT) demonstrates a whole series of potential leading to cancer treatment. To relieve the limitation of monotherapy, a multifunctional nanoplatform has been explored to realize the synergistic treatment efficiency. Herein, we establish a novel multifunctional nano-system which encapsulates chlorin e6 (Ce6, for SDT), perfluoropentane (PFP, for ultrasound imaging), and docetaxel (DTX, for chemotherapy) in a well-designed PLGA core–shell structure. The synergistic Ce6/PFP/DTX/PLGA nanoparticles (CPDP NPs) featured with excellent biocompatibility and stability primarily enable its further application. Upon low-intensity focused ultrasound (LIFU) irradiation, the enhanced ultrasound imaging could be revealed both in vitro and in vivo. More importantly, combined with LIFU, the nanoparticles exhibit intriguing antitumor capability through Ce6-induced cytotoxic reactive oxygen species as well as DTX releasing to generate a concerted therapeutic efficiency. Furthermore, this treating strategy actives a strong anti-metastasis capability by which lung metastatic nodules have been significantly reduced. The results indicate that the SDT-oriented nanoplatform combined with chemotherapy could be provided as a promising approach in elevating effective synergistic therapy and suppressing lung metastasis of breast cancer.

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Hydrogen Sulfide: An Emerging Precision Strategy for Gas Therapy

Ding

Chang

et al. 2021

Adv Healthcare Materials

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Advances in nanotechnology have enabled the rapid development of stimuli-responsive therapeutic nanomaterials for precision gas therapy. Hydrogen sulfide (H 2 S) is a significant gaseous signaling molecule with intrinsic biochemical properties, which exerts its various physiological effects under both normal and pathological conditions. Various nanomaterials with H 2 S-responsive properties, as new-generation therapeutic agents, are explored to guide therapeutic behaviors in biological milieu. The cross disciplinary of H 2 S is an emerging scientific hotspot that studies the chemical properties, biological mechanisms, and therapeutic effects of H 2 S. This review summarizes the state-of-art research on H 2 S-related nanomedicines. In particular, recent advances in H 2 S therapeutics for cancer, such as H 2 S-mediated gas therapy and H 2 S-related synergistic therapies (combined with chemotherapy, photodynamic therapy, photothermal therapy, and chemodynamic therapy) are highlighted. Versatile imaging techniques for real-time monitoring H 2 S during biological diagnosis are reviewed. Finally, the biosafety issues, current challenges, and potential possibilities in the evolution of H 2 S-based therapy that facilitate clinical translation to patients are discussed.

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Ce6-Conjugated and polydopamine-coated gold nanostars with enhanced photoacoustic imaging and photothermal/photodynamic therapy to inhibit lung metastasis of breast cancer

Abstract: Metastasis is the main cause of treatment failure in breast cancer, and integrated phototheranostics is a promising strategy to achieve both precision theranostics and metastasis inhibition. In this work, a...

Cited by 45 publications

References 59 publications

Current Photoactive Molecules for Targeted Therapy of Triple-Negative Breast Cancer

Current Photoactive Molecules for Targeted Therapy of Triple-Negative Breast Cancer

Low-Intensity Focused Ultrasound-Augmented Multifunctional Nanoparticles for Integrating Ultrasound Imaging and Synergistic Therapy of Metastatic Breast Cancer

Hydrogen Sulfide: An Emerging Precision Strategy for Gas Therapy

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