Cecal Microbial Succession and Its Apparent Association with Nutrient Metabolism in Broiler Chickens

Yin, Zhenchen; Ji, Shengwei; Yang, Jiantao; Guo, Wei; Li, Yulong; Ren, Zhouzheng; Yang, Xiaojun

doi:10.1128/msphere.00614-22

Cited by 14 publications

(5 citation statements)

References 75 publications

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“…Notably, significantly different microbiomes dominated by Firmicutes and Bacteroidetes (currently Bacillotaand Bacteroidota-dominated) have also been described in broiler chickens under extensive production systems (EPS) or intensive production systems (IPS) [35], which showed low and high phylogenetic diversity, respectively. At the same time, the results of cited and present studies are not identical, since the F1(−) pattern did not include the phylum Pseudomonadota (formerly Proteobacteria), the F1(+) pattern included the ACT component, and there were additional differences from the bacterial taxa found to be at the core of the EPS and IPS microbiomes [11].…”

Section: Discussioncontrasting

confidence: 72%

“…There is some evidence that the cecal microbiome composition and diversity may vary between chickens kept in different types of indoor cage and cage-free systems [8], the use of different types of litter substrates [9], and especially different diet supplementation [10]. In turn, varieties in the cecal microbiome influenced nutrient metabolism [11], including fat metabolism and fat deposition in broiler chickens [12], and were significant for growth promotion and individual differences in chicken body weight [13]. However, a comprehensive analysis of the relationship between cecal microbiome composition and chicken productivity is still unavailable.…”

Section: Introductionmentioning

confidence: 99%

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Broiler Chicken Cecal Microbiome and Poultry Farming Productivity: A Meta-Analysis

Deryabin,

Lazebnik,

Vlasenko

et al. 2024

Microorganisms

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The cecal microbial community plays an important role in chicken growth and development via effective feed conversion and essential metabolite production. The aim of this study was to define the microbial community’s variants in chickens’ ceca and to explore the most significant association between the microbiome compositions and poultry farming productivity. The meta-analysis included original data from 8 control broiler chicken groups fed with a standard basic diet and 32 experimental groups supplemented with various feed additives. Standard Illumina 16S-RNA gene sequencing technology was used to characterize the chicken cecal microbiome. Zootechnical data sets integrated with the European Production Effectiveness Factor (EPEF) were collected. Analysis of the bacterial taxa abundance and co-occurrence in chicken cecal microbiomes revealed two alternative patterns: Bacteroidota-dominated with decreased alpha biodiversity; and Bacillota-enriched, which included the Actinomycetota, Cyanobacteriota and Thermodesulfobacteriota phyla members, with increased biodiversity indices. Bacillota-enriched microbiome groups showed elevated total feed intake (especially due to the starter feed intake) and final body weight, and high EPEF values, while Bacteroidota-dominated microbiomes were negatively associated with poultry farming productivity. The meta-analysis results lay the basis for the development of chicken growth-promoting feed supplementations, aimed at the stimulation of beneficial and inhibition of harmful bacterial patterns, where relevant metagenomic data can be a tool for their control and selection.

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Section: Discussioncontrasting

confidence: 72%

Section: Introductionmentioning

confidence: 99%

Broiler Chicken Cecal Microbiome and Poultry Farming Productivity: A Meta-Analysis

Deryabin,

Lazebnik,

Vlasenko

et al. 2024

Microorganisms

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“…As the bird’s primary fermentative organ, the cecum possesses higher levels of DNA replicative viability than feces [ 208 ]. A balanced cecal microbiota diversity and composition have been used as an indicator of growth and health in poultry [ 209 , 210 , 211 ]. However, unlike mammals, in a commercial production setting, microbial contact is completely interrupted between domesticated parents and chicks.…”

Section: Cecal Microbiota Transplantation Social Stress and Injurious...mentioning

confidence: 99%

The Impact of Early-Life Cecal Microbiota Transplantation on Social Stress and Injurious Behaviors in Egg-Laying Chickens

Fu,

Hu,

Zhang

et al. 2024

Microorganisms

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Injurious behaviors (i.e., aggressive pecking, feather pecking, and cannibalism) in laying hens are a critical issue facing the egg industry due to increased social stress and related health and welfare issues as well as economic losses. In humans, stress-induced dysbiosis increases gut permeability, releasing various neuroactive factors, causing neuroinflammation and related neuropsychiatric disorders via the microbiota–gut–brain axis, and consequently increasing the frequency and intensity of aggression and violent behaviors. Restoration of the imbalanced gut microbial composition has become a novel treatment strategy for mental illnesses, such as depression, anxiety, bipolar disorder, schizophrenia, impulsivity, and compulsivity. A similar function of modulating gut microbial composition following stress challenge may be present in egg-laying chickens. The avian cecum, as a multi-purpose organ, has the greatest bacterial biodiversity (bacterial diversity, richness, and species composition) along the gastrointestinal tract, with vitally important functions in maintaining physiological and behavioral homeostasis, especially during the periods of stress. To identify the effects of the gut microbiome on injurious behaviors in egg-laying chickens, we have designed and tested the effects of transferring cecal contents from two divergently selected inbred chicken lines on social stress and stress-related injurious behaviors in recipient chicks of a commercial layer strain. This article reports the outcomes from a multi-year study on the modification of gut microbiota composition to reduce injurious behaviors in egg-laying chickens. An important discovery of this corpus of experiments is that injurious behaviors in chickens can be reduced or inhibited through modifying the gut microbiota composition and brain serotonergic activities via the gut–brain axis, without donor-recipient genetic effects.

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“…In recent years, the intestinal microbiota of poultry has received considerable attention as it plays an important role in various processes that affect the overall health, growth, and performance of poultry. These processes include nutrient digestion and absorption [ 22 ], nitrogen recycling by metabolising urea [ 23 ], supplying B vitamins to their hosts [ 24 ], production of essential amino acids [ 24 ], modulation of the immune system [ 25 ], and colonization resistance to enteric pathogens [ 26 ]. Within the intestinal tract, the twin ceca (located where the small and large intestines meet) contains the largest number and diversity of bacteria (10 11 -10 12 colony forming units/g) [ 27 ].…”

Section: Introductionmentioning

confidence: 99%

Dynamic effects of black soldier fly larvae meal on the cecal bacterial microbiota and prevalence of selected antimicrobial resistant determinants in broiler chickens

Lau,

Capitani,

Tien

et al. 2024

anim microbiome

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Background We had earlier described the growth-promoting and -depressive effects of replacing soybean meal (SBM) with low (12.5% and 25%) and high (50% and 100%) inclusion levels of black soldier fly larvae meal (BSFLM), respectively, in Ross x Ross 708 broiler chicken diets. Herein, using 16S rRNA gene amplicon sequencing, we investigated the effects of replacing SBM with increasing inclusion levels (0-100%) of BSFLM in broiler diets on the cecal bacterial community composition at each growth phase compared to broilers fed a basal corn-SBM diet with or without the in-feed antibiotic, bacitracin methylene disalicylate (BMD). We also evaluated the impact of low (12.5% and 25%) inclusion levels of BSFLM (LIL-BSFLM) on the prevalence of selected antimicrobial resistance genes (ARGs) in litter and cecal samples from 35-day-old birds. Results Compared to a conventional SBM-based broiler chicken diet, high (50 to100%) inclusion levels of BSFLM (HIL-BSFLM) significantly altered the cecal bacterial composition and structure, whereas LIL-BSFLM had a minimal effect. Differential abundance analysis further revealed that the ceca of birds fed 100% BSFLM consistently harbored a ~ 3 log-fold higher abundance of Romboutsia and a ~ 2 log-fold lower abundance of Shuttleworthia relative to those fed a BMD-supplemented control diet at all growth phases. Transient changes in the abundance of several potentially significant bacterial genera, primarily belonging to the class Clostridia, were also observed for birds fed HIL-BSFLM. At the finisher phase, Enterococci bacteria were enriched in the ceca of chickens raised without antibiotic, regardless of the level of dietary BSFLM. Additionally, bacitracin (bcrR) and macrolide (ermB) resistance genes were found to be less abundant in the ceca of chickens fed antibiotic-free diets, including either a corn-SBM or LIL-BSFLM diet. Conclusions Chickens fed a HIL-BSFLM presented with an imbalanced gut bacterial microbiota profile, which may be linked to the previously reported growth-depressing effects of a BSFLM diet. In contrast, LIL-BSFLM had a minimal effect on the composition of the cecal bacterial microbiota and did not enrich for selected ARGs. Thus, substitution of SBM with low levels of BSFLM in broiler diets could be a promising alternative to the antibiotic growth promoter, BMD, with the added-value of not enriching for bacitracin- and macrolide-associated ARGs.

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Cecal Microbial Succession and Its Apparent Association with Nutrient Metabolism in Broiler Chickens

Abstract: The poultry industry has become a global leader in livestock farming over the past few decades. Poultry production has a large consumer market as an integrated industry producing high-protein foods.

Cited by 14 publications

References 75 publications

Broiler Chicken Cecal Microbiome and Poultry Farming Productivity: A Meta-Analysis

Broiler Chicken Cecal Microbiome and Poultry Farming Productivity: A Meta-Analysis

The Impact of Early-Life Cecal Microbiota Transplantation on Social Stress and Injurious Behaviors in Egg-Laying Chickens

Dynamic effects of black soldier fly larvae meal on the cecal bacterial microbiota and prevalence of selected antimicrobial resistant determinants in broiler chickens

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