Cefadroxil versus penicillin in the treatment of streptococcal tonsillopharyngitis

Milatovic, Danica; Knauer, Jens

doi:10.1007/bf01963451

Cited by 23 publications

(7 citation statements)

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“…There was also a clear difference in the choice of antibiotics for the treatment of recurrent tonsillitis. Several investigations have shown a decrease in the relapse rate if an oral cephalosporin or clindamycin is used instead of penicillin V for the treatment of pharyngeal tonsillitis (25,26). Based on those studies, clindamycin or a cephalosporin is recommended for the treatment of recurrent tonsillitis in Sweden.…”

Section: Discussionmentioning

confidence: 99%

Differences in Antibiotic Prescribing Patterns Between General Practitioners in Scandinavia: A Questionnaire Study

Odenholt¹,

Bylander-Groth²,

Frimodt‐Møller³

et al. 2002

Scandinavian Journal of Infectious Diseases

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There has been a dramatic increase in the prevalence of antibiotic-resistant bacteria worldwide. In the Scandinavian countries at least 90% of total antibiotic use relates to outpatients and therefore it has become increasingly important to know the antibiotic prescription pattern of general practitioners (GPs) in order to implement and monitor changes in antibiotic prescribing. The aim of the present study was to evaluate the prescription patterns of GPs in Denmark, Norway and Sweden. In order to achieve a reasonable comparison, a questionnaire consisting of 7 case reports concerning upper and lower respiratory tract infections, urinary tract infections and skin and soft tissue infections was sent to 1,000 GPs in the 3 countries. In general, the guidelines for the treatment of bacterial infections in the individual countries were followed by the responders. In all 3 countries, penicillin V was still the drug most frequently used in upper and lower respiratory tract infections. The greatest difference in prescribing patterns among the countries was seen in the treatment of urinary tract infections, recurrent pharyngeal tonsillitis, acute otitis media and acute exacerbation of chronic bronchitis. There were also differences in the dosing regimens, length of treatment and use of diagnostic techniques.

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Section: Discussionmentioning

confidence: 99%

Differences in Antibiotic Prescribing Patterns Between General Practitioners in Scandinavia: A Questionnaire Study

Odenholt¹,

Bylander-Groth²,

Frimodt‐Møller³

et al. 2002

Scandinavian Journal of Infectious Diseases

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“…In the present study, three doses of cefcanel daloxate were chosen to bracket the doses of cephalosporins that had been used in other tonsillitis studies (4)(5)(6)(7)(8)(9). The prodrug characteristics, pharmacokinetics and betalactamase stability of cefcanel daloxate were expected to produce better tolerance and less bacteriological failure .…”

Section: Discussionmentioning

confidence: 99%

“…inactiva tion of penicillin by peni cillinase-produ cing bacterial s pecies in the ph a rynx. improper dose or in a d equ a te a ntibacteria l activity a t the infection s ite (4) . The bacteriological failure with other antimicrobia ls , p a rtic ularly oral cepha los porins, ranges from 2 to 14%, ra tes lower th a n those s een with PcV (2 -9).…”

Section: Cefcanel Daloxate Versus Pemicilline Dans Ia Pharyngoamygdalmentioning

confidence: 99%

Cefcanel Daloxate versus Penicillin in Acute Streptococcal Pharyngotonsillitis

Grunfeld

Sinclair

Nicolle

1993

Canadian Journal of Infectious Diseases and Medical Microbiolog

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A GRUNFELD, P SINCLAIR, LE NICOLLE AND THE CANADIAN TONSILLITIS STUDY GROUP. Cefcanel daloxate versus penicillin in acute streptococcal pharyngotonsillitis. Can J Infect Dis 1994;5(3):119-124. OBJECTIVE: To de termine the efficacy, safety and tolerance of cefcanel d a loxate and ph enoxymethylpenicillin (PcV) in the trealmen l of acule ph aryngo tonsillitis caused by bela-hemolytic streptococci group A (BHSGA). PATIENTS AND METHoos: Randomized, double-blind, multicentre sludy with subjects randomized 1: 1: 1: 1 lo four parallel trealmenl groups: cefcanel daloxale 150 mg bid. 300 mg b id, 600 mg daily and PcV 300 mg tid. Patients were treated for 10 days with clinical. bacteriological and safely evaluation al inclusion . during therapy (day 5), early after completion of therapy (day 14) and lwo weeks laler (day 28) . REsULTS: Of 340 subjects enrolled, 324 were valid for safely analysis and 249 for efficacy analysis. At the short term visit, clinical cure rales for cefcanel daloxale 300 mg bid and PcV groups were s imilar al approximately 70%. The cure rates for cefcanel daloxale 150 mg bid and 600 mg daily were significantly worse at 57.4 and 54.4%. Approximately 80% of all prethempy throal swabs grew BIISGA. All BHSGA were susceptible or intermediately susceptible to PcV and cefcanel. The bacteria l elimination rate for cefcanel daloxate was 82.8% and for PcV it was 89 .8%. The elimination rate was s ignificantly lower in the cefcanel daloxate 150 mg bid and 6 00 mg daily gro u ps. The clin ical cure rates and U1e bacteriological elimination rates increased by about 10% for cefcanel daloxate 300 mg bid and the PcV groups at the lasl valid visit and rem ained s ignificantly better than tl1e other two cefcanel daloxate doses. Adverse events were not significantly different among the four treain1enl groups. CONCLUSIONs: Cefcanel daloxate 300 mg b id was as effective and as well tolerated as PcV 300 mg tid in the treatment of acute pharyngotonsillitis. A lower dose or once-daily dose regimen of cefcanel daloxate was not as effective clinically or bacleriologically. (Pour resume. voir

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“…Cephalosporins have been shown to be more effective than penicillin V in treating primary beta‐hemolytic group A streptococcal pharyngotonsillitis (37, 55, 67). Cephalosporins may enable shorter treatment regimens than penicillin V, and some patients may only need to be dosed once daily (68).…”

Section: Beta‐hemolyic Group a Streptococcimentioning

confidence: 99%