Cefathiamidine-Induced Toxic Epidermal Necrolysis in a Child

Abstract

BackgroundToxic epidermal necrolysis (TEN) is the most serious type of drug eruption, which is often caused by adverse drug reactions and is characterized by acute onset and rapid progression. TNE usually causes extensive skin and mucosal damage in a short period of time. The whole body can spread flaccid blisters and large area of epidermolysis. It not only affects the skin, but also invades numerous organs, and even causes serious complications such as sepsis and shock, which endangers the lives of patients. The incidence of TNE is low and common in women and old people, but is rare in children, and the mortality rate is high 25-35% [1-2]. Here, we reported a child with TEN induced by cefathiamidine.