Cefazolin Treatment of Bacterial Infections

Abstract

Cefazolin sodium was used to treat 20 serious bacterial infections in 19 patients, 11 of whom were infected with coagulase-positive Staphylococci. Clinical and bacteriologic success were initially obtained in 15 patients with 16 infections. 2 additional patients were cured after surgery for removal of foreign bodies and a second course of the antibiotic. 1 asplenic patient had bacteremia and died 5 days after initiating therapy with negative blood cultures and multiple abscesses. 1 patient with endocarditis relapsed 19 months after treatment with 6 weeks of cefazolin and prolonged oral antibiotics. Calculated median, trough, free drug levels were 1.5–15.3 times the minimum inhibitory concentration for 27 of 29 pathogens.

Penetration of cefazolin into normal and osteomyelitic canine cortical bone

“…Cefazolin binds to serum proteins to a different extent in dogs and humans. In humans, cefazolin is highly protein bound, with reports ranging from 73 to 92% (9,10,12,13,22,24,30,31), whereas in dogs reports have varied from 32.5% (20) to 47% (13) to 80% (37). The results of this study indicate that serum protein binding of cefazolin in dogs is relatively low, 35.8% by isotope assay and 38.8% by bioassay.…”