Aspirin and urticaria correlation has not been fully understood. The pharmacological inference is suspected to be the diversion of arachidonic acid metabolism. Aspirin sensitivity can aggravate pre-existing chronic urticaria and in some instances causes acute urticaria. We report a case of a 53-year old male, recently diagnosed with stroke, who presented with complaints of multiple rash over trunk and upper extremity with aspirin. NSAIDs induced urticarial are usually neglected by physicians during diagnosis. Keywords: Aspirin, urticarial, stroke, hemiplegiaIntroduction: Aspirin is a drug which is widely used to reduce the risk of stroke, transient ischemic attack, and cardiovascular events. This is due to its antithrombotic properties by irreversibly inhibiting the cyclooxygenase enzyme, reducing the synthesis of Thromboxane A2 and thus subsequently reducing platelet aggregation [1-3]. Aspirin and NSAIDs' pharmacological properties also result in adverse reactions like GI upset, renal toxicity, and hemorrhagic complications, as well as potentiate hypersensitivity reactions [4]. Aspirin Hypersensitivity is reported by 0.9 to 1.5% of the general population [5]. Hypersensitivity reactions to NSAIDs are classified on the basis of their involvement of the skin, like