Cefmenoxime

Campoli-Richards, Deborah M.; Todd, Peter A.

doi:10.2165/00003495-198734020-00002

Cited by 17 publications

(2 citation statements)

References 82 publications

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“…Cipro oxacin inhibits bacterial DNA gyrase, making it a broad-spectrum antibacterial drug. It is highly susceptible to Gram-negative bacteria in vitro and moderately susceptible to Gram-positive bacteria [25]. The emergence of resistance to various classes of antibiotics can be linked to a number of factors, such as altered target-site architecture, altered cell membrane permeability, and e ux-pump mechanisms that lower antibiotic concentrations [26].…”

Section: Mic Of Aunps Cip and Cip @Au Nps Evaluationmentioning

confidence: 99%

Synthesis of Ciprofloxacin-Conjugated Gold Nanoparticles and their Study Antibacterial Effects on Growth Biofilm Formation Through Nebulizer Mask Against Respiratory Infection

Hasoon,

Jawad,

Abdulsahib

2023

Plasmonics

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An effective strategy has been identi ed as using antibiotic conjugated nanoparticles. The main goal of this research was to increase the biosynthesis of gold nanoparticles by conjugating it with cipro oxacin. The optical, structural and biological properties of gold (Au) nanoparticles (NPs) and their conjugated form with cipro oxacin (CIP@AuNPs). Using a simple and cost-effective method pulsed-laser ablation technique (PLAL). were studied using UV-VIS spectroscopy, X-ray diffraction(XRD), Transmission electron microscope (TEM), and Fourier transform infrared (FTIR), The ndings demonstrated that TEM was used to determine the size and shape of nanoparticles with an average particle size of less than 20 nm. Investigated the antibacterial effects of AuNPs, antibiotic (cipro oxacin) and CIP@AuNPs against two types of bacteria, namely, the gram-negative bacteria Klebsellia pneumonia and the gram-positive bacteria Streptococcus pneumonia. The well-diffusion method demonstrated that the effectiveness of (CIP@AuNPs) was greater than that of the antibiotic cipro oxacin alone or Au NPs alone. Bacterial isolates tested for antibacterial susceptibility to the current study's antibiotics showed high resistance to them. The antimicrobial activity test revealed the largest inhibition zone in as Streptococcus pneumonia compared to Klebsiella pneumonia, with a more potent effect for Cipro oxacin conjugated gold nanoparticles when compared with Cipro oxacin alone and Au NPs alone. Further research was done on their capacity to prevent bio lm formation. This nding was supported by research using atomic force microscopy (AFM) to examine how Cipro oxacin conjugated gold nanoparticles affected the development of bacterial bio lms in nebulizer masks. The combination of cipro oxacin-conjugated gold nanoparticles may be used as a preservative of a Nebulizer mask. Through the prevent the formation of microbial bio lms in Nebulizer mask. The Cipro oxacin conjugated gold nanoparticles also showed antioxidant activities by DPPH assay. Consequently, these investigations reveal that the prepared particles may be useful for the development of antioxidant drugs. Conclusion: Cipro oxacin @Au nanoparticles are effective against multidrug-resistant bacteria in vitro and seem to be a good antibacterial agent.

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Section: Mic Of Aunps Cip and Cip @Au Nps Evaluationmentioning

confidence: 99%

Synthesis of Ciprofloxacin-Conjugated Gold Nanoparticles and their Study Antibacterial Effects on Growth Biofilm Formation Through Nebulizer Mask Against Respiratory Infection

Hasoon,

Jawad,

Abdulsahib

2023

Plasmonics

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“…Other examples exist, e. g . Azathioprine as immunosuppressant, [9,10] Triclabendazole [11] as an anti‐parasitic drug and Cefmenoxime as a third‐generation cephalosporin antibiotic [12] …”

Section: Figurementioning

confidence: 99%

Thiofunctionalization of Electron‐Rich Heteroarenes through Magnesiation and Trapping with Octasulfur

et al. 2021

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Herein we report a site‐selective and thiol‐free thiofunctionalization of electron‐rich heteroarenes. After a selective ortho‐magnesiation, the use of S8 followed by an electrophile allows direct access to S‐alkyl or ‐aryl derivatives. In situ oxidation provides the corresponding sulfoxide and sulfone derivatives. Applying this protocol, Cerlapirdine was prepared in 4 steps with 28% overall yield.

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2‐Aminothiazoles

2018

Privileged Structures in Drug Discovery

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Cefmenoxime

Cited by 17 publications

References 82 publications

Synthesis of Ciprofloxacin-Conjugated Gold Nanoparticles and their Study Antibacterial Effects on Growth Biofilm Formation Through Nebulizer Mask Against Respiratory Infection

Synthesis of Ciprofloxacin-Conjugated Gold Nanoparticles and their Study Antibacterial Effects on Growth Biofilm Formation Through Nebulizer Mask Against Respiratory Infection

Thiofunctionalization of Electron‐Rich Heteroarenes through Magnesiation and Trapping with Octasulfur

2‐Aminothiazoles

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