Cefoperazone Sodium in the Treatment of Serious Bacterial Infections in 2,100 Adults and Children: Multicentered Trials in Europe, Latin America, and Australasia

Gordon, Alfred; Phyfferoen, M.

doi:10.1093/clinids/5.supplement_1.s188

Cited by 16 publications

(4 citation statements)

References 6 publications

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“…The drug-release results were as follows: pH 3.0 > 5.8 > 7.0, with the highest amount being released at pH = 3.0 (34.3 mg g −1 ). Cefoperazone sodiuma popular antibiotic 247,248 was also investigated as an example drug-model. The absorbance spectra of the solution containing cefoperazone alongside the synthetic peptide or La 3+ ions (or both) closely resembled the absorbance profile of the free-drug.…”

Section: Peptide-modulated Self-assembly Of Luminescent Structuresmentioning

confidence: 99%

Modified synthetic peptides: from therapeutics to chemosensors

Wynne,

Elmes

2024

Sens. Diagn.

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Section: Peptide-modulated Self-assembly Of Luminescent Structuresmentioning

confidence: 99%

Modified synthetic peptides: from therapeutics to chemosensors

Wynne,

Elmes

2024

Sens. Diagn.

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“…In reviewing the clinical experience in other countries, Gordon and Phyfferoen reported a 94% satisfactory clinical response rate and an 89% bacteriological eradication rate in 571 cases of urinary tract infection. 81 File and Tan have summarized the results of comparative and noncomparative clinical trials conducted in the United States. 106 Over 200 patients with acute urinary tract infections have been enrolled in these trials.…”

Section: Therapeutic Indicationsmentioning

confidence: 99%

“…In reviewing clinical trials in Europe, Latin America, and Australia, Gordon and Phyfferoen reported that cefoperazone therapy had been evaluated in 417 children, ranging in age from birth to 14 years. 81 Infections included bronchitis, pertussis, enteritis, biliary tract infection, urinary tract infection, septicemia, and ear, nose and throat infection. Cefoperazone therapy was judged to be clinically effective in 89% of these children, and bacteriological cure was achieved in 92%.…”

Section: Therapeutic Indicationsmentioning

confidence: 99%

Antimicrobial Activity, Pharmacokinetics, Adverse Reactions, and Therapeutic Indications of Cefoperazone

Funk

Strausbaugh

1982

Pharmacotherapy

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Cefoperazone is a parenteral cephalosporin antibiotic that is pending approval by the U. S. Food and Drug Administration. Compared to most other cephalosporins cefoperazone has a greatly expanded spectrum of bactericidal activity that encompasses most aerobic gram-positive bacteria except enterococci, most aerobic gram-negative bacteria, including a majority of Pseudomonas aeruginosa strains, and a number of pathogenic anaerobic bacteria. Its long serum half-life, approximately two hours, permits a twelve hourly dosing schedule. No dosage modification is required in patients with renal insufficiency, and only minor modification is needed in patients with hepatic insufficiency or biliary obstruction. Clinical trials have established cefoperazone's efficacy in lower respiratory tract infections, urinary tract infections, and a variety of other bacterial infections. Adverse reactions have been infrequent, and few serious reactions have been identified. Cefoperazone is a promising new agent for the treatment of gram-negative bacillary and polymicrobial infections, especially in settings that require empiric therapy.

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“…Clinical studies proved cefoperazone's efficiency in 92% of lower respiratory tract infections, 81% of urinary tract infections, 98% of gynecological infections, and 90% of a mixture of intra-abdominal, wound, and soft tissue infections. The clinical response was satisfactory in over 90% of infections with organisms normally susceptible to cephalosporins [6]. It acts by inhibiting the biosynthesis of cell wall mucopeptide, the third and last stage of bacterial cell wall synthesis.…”

Section: Introductionmentioning

confidence: 99%

Vibrational Analysis and Concentration Dependent SERS Study of Cefoperazone

Faur,

Tóth,

Magyari

et al. 2024

Chemosensors

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Cefoperazone is a broad-spectrum antibiotic that is extremely efficient in the treatment of respiratory, abdominal, or genital infections. Vibrational spectroscopic techniques, FT-IR, Raman, and SERS, along with DFT calculations, were involved in investigating the normal modes of vibration and adsorption behavior of this antibiotic. Using both the experimental and theoretical data, the bands in the Raman and IR spectra were assigned to the normal vibrational modes. The SERS spectra were successively obtained by using silver and gold colloidal nanoparticles as a substrate. Their analysis revealed that the molecule is chemisorbed on the nanostructured surface through the as-denoted nitrogen ring. Changes observed in the SERS spectra recorded at different cefoperazone concentrations, i.e., modifications in the relative intensity of specific bands suggest the reorientation of adsorbed molecules towards the metal surface.

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Cefoperazone Sodium in the Treatment of Serious Bacterial Infections in 2,100 Adults and Children: Multicentered Trials in Europe, Latin America, and Australasia

Cited by 16 publications

References 6 publications

Modified synthetic peptides: from therapeutics to chemosensors

Modified synthetic peptides: from therapeutics to chemosensors

Antimicrobial Activity, Pharmacokinetics, Adverse Reactions, and Therapeutic Indications of Cefoperazone

Vibrational Analysis and Concentration Dependent SERS Study of Cefoperazone

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