Cefpodoxime Proxetil Fast Dissolving Tablets: Comparative Study

Kumar, Inder; Pandit, Vinay

doi:10.22159/ijpps.2020v12i11.39291

Cited by 9 publications

(9 citation statements)

References 16 publications

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“…Peak potentials for both peaks were also remained constant. pKa values of ETO and TCC are 4.65 [21] and 10 [22], respectively. According to these values, while in acidic solutions TCC is expected to fully ionize to form cationic species, ETO can be in neutral form.…”

Section: Resultsmentioning

confidence: 99%

Electroanalytical Investigation and Simultaneous Determination of Etodolac and Thiocolchicoside at a Non‐modified Glassy Carbon Electrode in Anionic Surfactant Media

et al. 2021

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In this study, a differential pulse voltammetry method was designed for the simultaneous determination of etodolac and thiocolchicoside in a tablet dosage form. This method is a sensitive, costless and reproducible one initially designed for the simultaneous determination of etodolac and thiocolchicoside using bare/unmodified glassy carbon electrode in the presence of sodium dodecyl sulfate. At optimized conditions, the method showed linear responses with etodolac and thiocolchicoside concentration in the range of 1 μM to 80 μM. The limits of detection and quantification were calculated as 0.11 μM and 0.38 μM for etodolac and 0.20 μM and 0.67 μM for thiocolchicoside, respectively.

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Section: Resultsmentioning

confidence: 99%

Electroanalytical Investigation and Simultaneous Determination of Etodolac and Thiocolchicoside at a Non‐modified Glassy Carbon Electrode in Anionic Surfactant Media

et al. 2021

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“…It is also helpful for localized actions like teething, mouth ulcers, toothaches, and cold sores where a local anesthetic is desired. [10,11] The technology of transdermal patches is the foundation for fast-dissolving oral films. When it comes to size, shape, and thickness, films are very similar to postage stamps [.12].…”

Section: Figure 1: Oral Thin Filmmentioning

confidence: 99%

Encyclopedic Overview on Orodispersible Films

et al. 2023

IJFMR

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Fast-dissolving drug delivery systems have gained attention and acceptance recently as innovative drug delivery methods that seek to improve patient compliance while improving the safety and effectiveness of a therapeutic molecule by preparing it for administration in a traditional oral dosage form. Some businesses unveiled more durable fast-dissolving medication delivery systems. The tongue is either the floor or the top of the film. This film instantly dissolves when applied to the tongue, releasing the medication, which then dissolves in saliva. The saliva travels down into the stomach, where it absorbs some medications from the mouth, throat, and esophagus. In this instance, improving drug absorption, reducing choking danger, and improving mouth feel are important.

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“…20 tablets from each batch were weighed separately (W initial) and placed in the friabilator, which was then operated for 100 revolutions at 25 rpm [21]. The tablets were reweighed (W final) and the percentage friability was calculated for each batch by using the following formula [22].…”

Section: Thicknessmentioning

confidence: 99%

Formulation Development and Evaluation of Chronomodulated Drug Delivery System by Zafirlukast

Krishna¹,

Jayanthi²,

Madhukar³

2021

Int J App Pharm

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Objective: The main objective of the present study was to formulate and evaluate a time-controlled single-unit oral pulsatile drug delivery system containing Zafirlukast for the prevention of nocturnal asthma attacks. To provide time-scheduled drug release for Asthma disease. It is used for preventing asthmatic attacks at early morning. Pulsatile release dosage form is increasing patient compliance by reducing the dosing frequency, especially in the early morning. Methods: Core tablets were prepared by incorporating different concentrations of natural and synthetic super disintegrants. Drug-containing core tablets (ZC1-ZC15) with different compositions of natural super disintegrants (Plantago ovata seed powder, Locust bean gum) synthetic super disintegrants (Sodium starch glycolate (SSG), Cross carmellose sodium (CCS), Crospovidone (CP)) were prepared by direct compression technique. The core tablets were subjected to pre-formulation, physicochemical and In vitro drug release studies. The fast disintegrating core tablet formulation was selected and press-coated tablets (P1-P11) were prepared with different compositions of hydrophobic polymers Eudragit RS100, Eudragit RL 100, Ethylcellulose and hydrophilic polymers Hydroxypropyl methylcellulose K4M, K100M. The optimized formulation was selected and quantified based on in vitro drug release profile in simulated gastric and intestinal fluids. Results: The pre and post-compression parameters of tablets were also found to be within limits. Formulation ZC5 with 16 mg of Locust bean gum showed the least disintegrating time, i.e., 22.13 sec, and was selected as the best immediate release core tablet. The press-coated tablet formulation P8 having 62.5 mg Eudragit RS100 and 62.5 mg of HPMC K4M in ratio 1:1 over the core tablet ZC5 showed rapid and drug release nearly after 4 h lag time and 98.86 % up to 12 h. Accelerated stability studies of the optimized formulation P8 indicated no significant difference in release profile after 3 mo. Conclusion: The in vitro dissolution study showed that lag time before drug release was highly affected by the coating amount level and nature of coating polymer used. Time-controlled pulsatile release tablets can be prepared using press-coating techniques.

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Cefpodoxime Proxetil Fast Dissolving Tablets: Comparative Study

Cited by 9 publications

References 16 publications

Electroanalytical Investigation and Simultaneous Determination of Etodolac and Thiocolchicoside at a Non‐modified Glassy Carbon Electrode in Anionic Surfactant Media

Electroanalytical Investigation and Simultaneous Determination of Etodolac and Thiocolchicoside at a Non‐modified Glassy Carbon Electrode in Anionic Surfactant Media

Encyclopedic Overview on Orodispersible Films

Formulation Development and Evaluation of Chronomodulated Drug Delivery System by Zafirlukast

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