Ceftezole, a new cephalosporin C derivative. II. Distribution and excretion in parenteral administration.

Harada, Yoko; Matsubara, Shuzo; Kakimoto, Morio; Noto, Takao; Nehashi, Toshiyuki; Kimura, Takao; Suzuki, Seikichi; Ogawa, Hisahito; Koyama, Kenjiro

doi:10.7164/antibiotics.29.1071

Cited by 5 publications

(4 citation statements)

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“…3). Clinically, ceftezole is po tently active against various infections due to gram-positive and gram-negative bacteria except Serratia, Pseudomonas and a few other bacteria [4,14,15].…”

Section: Introductionmentioning

confidence: 99%

Pharmacokinetics of Ceftezole in Patients with Normal and Impaired Renal Function

Ohkawa¹,

Kuroda²

1980

Chemotherapy

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The pharmacokinetics of ceftezole, a new cephalosporin antibiotic, was studied in 15 patients with normal and impaired renal function after administering the drug in a 2-hour intravenous drip infusion of 2 g, 81% of the infused dose was excreted in the first 6 h urine of the patients with normal renal function. The pharmacokinetic parameters of ceftezole were obtained by analyzing the serum level data of the drug using a one-compartment open model. The mean serum half-life of ceftezole was 0.64 h in patients with normal renal function and was prolonged to 10.7 h in patients with severely impaired renal function (creatinine clearance: 0-2.6 ml/min.). There was a significant linear correlation between the elimination rate of the drug and creatinine clearance.

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“…3). Clinically, ceftezole is po tently active against various infections due to gram-positive and gram-negative bacteria except Serratia, Pseudomonas and a few other bacteria [4,14,15].…”

Section: Introductionmentioning

confidence: 99%

Pharmacokinetics of Ceftezole in Patients with Normal and Impaired Renal Function

Ohkawa¹,

Kuroda²

1980

Chemotherapy

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“…In 24 h, 87%-93% of intramuscular doses was recovered as unchanged drug in urine. No microbiologically active metabolites were found in human urine (IsmYAMA et al 1976;NIsmDA et al 1976a;HARADA et al 1976).…”

Section: Ceftezolementioning

confidence: 99%

“…Urinary excretion accounts for 75%-85% of the dose in dogs, and rabbits excrete over 90% in this manner (NIsmDA et al 1976a;ISmYAMA et al 1976;HARADA et al 1976). …”

Section: Ceftezolementioning

confidence: 99%

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Pharmacokinetics of β-Lactam Antibiotics

Kwan¹

1983

Antibiotics

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The potential environmental risks of pharmaceuticals in Vietnamese aquatic systems: case study of antibiotics and synthetic hormones

Thủy¹,

Nguyen²

2013

Environ Sci Pollut Res

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Presently, many pharmaceuticals are listed as emerging contaminants since they are considered to be great potential threats to environmental ecosystems. These contaminants, thus, present significant research interest due to their extensive use and their physicochemical and toxicological properties. This review discusses a whole range of findings that address various aspects of the usage, occurrence, and potentially environmental risks of pharmaceuticals released from various anthropogenic sources, with emphasis on the aquatic systems in Vietnam. The published information and collected data on the usage and occurrence of antibiotics and synthetic hormone in effluents and aquatic systems of Vietnam is reported. This is followed by a potential ecological risk assessment of these pollutants. The extensive use of antibiotics and synthetic hormones in Vietnam could cause the discharge and accumulation of these contaminants in the aquatic systems and potentially poses serious risks for ecosystems. Vietnam is known to have extensively used antibiotics and synthetic hormones, so these contaminants are inevitably detected in aquatic systems. Thus, an appropriate monitoring program of these contaminants is urgently needed in order to mitigate their negative effects and protect the ecosystems.

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Ceftezole, a new cephalosporin C derivative. II. Distribution and excretion in parenteral administration.

Cited by 5 publications

References 0 publications

Pharmacokinetics of Ceftezole in Patients with Normal and Impaired Renal Function

Pharmacokinetics of Ceftezole in Patients with Normal and Impaired Renal Function

Pharmacokinetics of β-Lactam Antibiotics

The potential environmental risks of pharmaceuticals in Vietnamese aquatic systems: case study of antibiotics and synthetic hormones

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