Ceftriaxone-induced Kounis syndrome: A case report and review of the literature

Ali, S.; Athar, M.; Rahman, R.; Rehman, F.

doi:10.1016/j.redare.2023.01.005

Cited by 3 publications

(1 citation statement)

References 12 publications

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“…Furthermore, elevated levels of cardiac enzymes, tryptase, and eosinophilia can also serve as indications of Kounis syndrome. In all reported cases involving pediatric patients, ischemic changes (ST elevation and ST depression) were observed on the ECG, except for one case where a 15-year-old patient with Kounis syndrome, due to a wasp sting, displayed normal findings on the ECG [34,40,[64][65][66]72,[83][84][85][86][87][88][89][90]. Similarly, in the case of the adult case reports, it was also observed that ischemic changes were noted on the electrocardiogram (ECG).…”

Section: Discussionmentioning

confidence: 94%

Exploring Variations in Etiology and Clinical Presentations of Kounis Syndrome Across Pediatric and Adult Populations: A Comprehensive Review

Youcefi,

Abu Saadeh,

Karaca

et al. 2024

Cureus

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Kounis syndrome (KS), recognized as a rare yet significant form of acute coronary syndrome precipitated by allergy-mediated mechanisms, poses diagnostic challenges due to its varied clinical presentations and under-recognition. Despite its relevance across diverse populations, comprehensive insights into age-specific characteristics and management remain limited. The analysis of 420 studies yielded a total of 466 case reports of Kounis syndrome, categorized into pediatric (n = 31) and adult (n = 435) populations. After rigorous screening, 330 adult and 20 pediatric case reports were included for further analysis. Triggering factors were identified, with drugs (other) being the most prevalent in both groups. The breakdown of triggering factors, such as drugs (antibiotics), bee/wasp stings, and contrast media, was elucidated. Variations in presenting symptoms, diagnostic investigations, and treatment modalities between pediatric and adult populations were observed. Notably, all pediatric cases were diagnosed with subtype I Kounis syndrome and demonstrated favorable outcomes without any reported fatalities, whereas adult cases exhibited a broader range of Kounis subtypes. Mortality was recorded solely in adult case reports, with no fatalities reported among pediatric cases. These findings underscore the importance of understanding the nuances in the clinical presentation and management of Kounis syndrome across different age groups.

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Section: Discussionmentioning

confidence: 94%

Exploring Variations in Etiology and Clinical Presentations of Kounis Syndrome Across Pediatric and Adult Populations: A Comprehensive Review

Youcefi,

Abu Saadeh,

Karaca

et al. 2024

Cureus

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Ceftriaxone

2024

Reactions Weekly

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Cardiac Arrest Due to Kounis Syndrome Following Cephazolin Administration During Surgery Under Local Anesthesia

Obata,

Saito-Sasaki,

Sugino

et al. 2023

Cureus

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The Kounis syndrome is described as the co-occurrence of allergic responses brought on by mast cell activation and acute coronary syndromes. We present a case of Kounis syndrome leading to cardiac arrest following the cephazolin sodium administration during the surgical resection of basal cell carcinoma. An 87-year-old woman was diagnosed with basal cell cancer. She received surgical excision of the tumor while anesthetized with lidocaine hydrochloride and 1% epinephrine. This patient began to itch around five minutes after cefazolin (CEZ) administration and eventually experienced cardiac arrest following diffuse rashes that spread throughout her body and edema in her eyelids. In line with the response, the electrocardiogram (ECG) also showed an elevated ST segment in V1-6, leading to possibly the diagnosis of Kounis syndrome. We also review the literature on Kounis syndrome following CEZ administration.

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Ceftriaxone-induced Kounis syndrome: A case report and review of the literature

Cited by 3 publications

References 12 publications

Exploring Variations in Etiology and Clinical Presentations of Kounis Syndrome Across Pediatric and Adult Populations: A Comprehensive Review

Exploring Variations in Etiology and Clinical Presentations of Kounis Syndrome Across Pediatric and Adult Populations: A Comprehensive Review

Ceftriaxone

Cardiac Arrest Due to Kounis Syndrome Following Cephazolin Administration During Surgery Under Local Anesthesia

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