Ceftriaxone sodium loaded onto polymer-lipid hybrid nanoparticles enhances antibacterial effect on gram-negative and gram-positive bacteria: Effects of lipid - polymer ratio on particles size, characteristics, in vitro drug release and antibacterial drug efficacy

Biocompatible antibiotic-coupled nickel-titanium nanoparticles as a potential coating material for biomedical devices

“…For ceftriaxone ( Fig. 4 C), IR peaks were observed at 1762 cm −1 , and 1602 cm −1 , which can be attributed to the amide (C=O and –NH) vibrations, and 1365 cm −1 is related to –C=N, and O–H vibrations as previously reported [ 42 , 43 ]. The peak at 1526 cm −1 is attributed to the aromatic ring vibrations [ 43 ].…”

“…4 C), IR peaks were observed at 1762 cm −1 , and 1602 cm −1 , which can be attributed to the amide (C=O and –NH) vibrations, and 1365 cm −1 is related to –C=N, and O–H vibrations as previously reported [ 42 , 43 ]. The peak at 1526 cm −1 is attributed to the aromatic ring vibrations [ 43 ]. The phosphonate vibration was observed at 1215 cm −1 , as previously reported of COOHPA bound on NiTi nanoparticles [ 34 ].…”

“…Two drugs of interest in this study were the antibiotics vancomycin and ceftriaxone.. Vancomycin is commonly used against multidrug-resistant Staphylococcus infections [ 7 , 39 , 40 ] whereas ceftriaxone is a third-generation β-lactam drug targeting Gram-positive bacteria [ [41] , [42] , [43] ]. Ceftriaxone has one primary amino group whereas vancomycin has both primary and secondary amino groups ( Fig.…”

Synthesis and functionalization of zinc phosphate@polyglycidyl methacrylate composites for antimicrobial drug immobilization and controlled release: an in vitro study

“…75 The release study of free CFX with under similar experimental conditions revealed its first-order release profile meaning that it can cause a sudden release of the antibiotic inside the body. 76 This may cause poor pharmacokinetics of the drug inside the body resulting in some inevitable side effects for the patient. 77 However, the DETA and l -cysteine modified ZnP@PGMA complexes helped to maintain a sustainable release profile of CFX by releasing the drug molecules into the system in a controlled manner.…”

Development, Characterization and Short-Term Stability Studies of Chitosan-Lipid Hybrid Nanocarrier System

“…Polymer-lipid hybrid nanoparticles are one of the recommended nanocarriers for the delivery of both hydrophilic and lipophilic drugs. 13 With this system, it is possible to overcome the limitations of polymeric and lipid nanocarriers and take advantage of both. In the present study, a chitosan-based polymer lipid nanocarrier system was developed so that they could act as a matrix and be useful for sustained release, enhancing bioavailability, increasing the entrapment efficiency of drugs, and targeting the intestinal portion of the GIT.…”