Ceftriaxone versus clavulanate-potentiated amoxycillin for prophylaxis against post-operative sepsis in biliary surgery: A prospective randomized study in 200 patients

el-Mufti, M; Rakas, F. S.; Glessa, A.; Abdulhadi, Asaad S.; Ekgam, S.; Fraitis, Farkash; Zaidi, Jelani

doi:10.1185/03007998909110135

Cited by 12 publications

(20 citation statements)

References 7 publications

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“…injection are higher than the minimum inhibitory concentrations (>MIC) for most Gram-negative bacteria usually isolated in the bile. Such results are similar to those reported with ceftriaxone, which is considered the gold-standard for biliary tract surgery 24 .…”

Section: Antibiotic Prophylaxis In Clean-contaminated Abdominal Surgesupporting

confidence: 89%

“…Here again cefepime has been shown to be advantageous in terms of effectiveness, bacterial resistance and cost-benefit analysis [21][22][23] . Similar results were reported at the end of '80 using ceftriaxone 24 . We have underlined that pancreatic surgery (not for acute necrotic pancreatitis) belongs to this class of operations and that short-ter m antibiotic prophylaxis may be enough, provided that the antibiotic is one of those with good penetration into human pancreas [25][26][27][28][29][30][31] .…”

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confidence: 88%

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Antibiotic Prophylaxis and Treatment of Surgical Abdominal Sepsis

Colizza¹,

Rossi²

2001

Journal of Chemotherapy

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The incidence of surgical abdominal sepsis is related to the operation, patient and skill of the surgeon, ranging from <2-3% for laparoscopic cholecystectomy to >35-40% in overt peritonitis. Aged, obese, diabetic, neoplastic, acute patients have the highest incidence of sepsis. Antibiotic prophylaxis significantly reduces the incidence of postoperative infections for Class II and II operations. The proper timing (30-60 min before incision), choice of antibiotic (related to possible pathogens) and correct duration are essential. Ultra-short prophylaxis (only one administration) may be effective in most class II procedures and a cephalosporin can be used. Class II operations (colorectal) may require a booster dose soon after surgery or during surgery exceeding 3 h. The most effective regimen may include: ampicillin, clindamycin, I- II- III- or IV-generation cephalosporins, amoxycillin, aminoglycosides, metronidazole have been used alone and in combination. Combination prophylaxis should be active against aerobic and anaerobic bacteria. Treatment of surgical abdominal sepsis may be primary, seconday or tertiary. Surgery should remove the pathologic lesion, and antibiotics reduce the general effects of sepsis and infectious complications. This article presents information on the general rules for correct prophylaxis and treatment.

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Section: Antibiotic Prophylaxis In Clean-contaminated Abdominal Surgesupporting

confidence: 89%

Section: Downloaded By [Orta Dogu Teknik Universitesi] At 15:10 04 Apsupporting

confidence: 88%

Antibiotic Prophylaxis and Treatment of Surgical Abdominal Sepsis

Colizza¹,

Rossi²

2001

Journal of Chemotherapy

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“…It is noteworthy that significantly fewer cases of pneumonia were observed on ceftriaxone prophylaxis -a result demonstrated for single-dose prophylaxis hitherto only in studies with 24-hour cover by a long-acting, broad-spectrum antibiotic [20][21][22][23][24][25][26][27]. However, the fact that respiratory and urinary tract infections are not effectively reduced by a short prophylaxis of 2-4 h [28,29] should not tempt surgeons into prescribing perioperative antibiotics for more than 24 h. Administration beyond this period is not only unnecessary for prophylaxis but also potentially dangerous, since increased selective pressure may favor the development of resistant bacterial strains.…”

Section: Discussionmentioning

confidence: 99%

Antimicrobial Prophylaxis in Laparoscopic and Conventional Cholecystectomy

Lippert¹,

Gastinger²

1998

Chemotherapy

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Background: Postoperative infection following cholecystectomy poses a significant threat to recovery, with major cost repercussions. Though antimicrobial prophylaxis is commonly practiced, its value – particularly in laparoscopic cholecystectomy – has not yet been adequately documented. Method: In a prospective multicenter quality assurance study in 28 German hospitals, an analysis of data collected on 4,477 patients undergoing conventional (n = 1,349) or laparoscopic (n = 3,128) cholecystectomy was performed; 2,217 patients received and 2,260 did not obtain perioperative antibiotic cover. Results: Postoperative infections occurred in a total of 136 patients, with infection rates of 5.0% in those without prophylaxis, 0.8% in those on ceftriaxone, and 1.2% in those on other antibiotic regimens. Patients receiving prophylaxis fared significantly better than those with no prophylaxis in terms of the rate of postoperative wound infections, chest infections, other complications, reoperation and mortality. Conclusion: Neither laparoscopic nor conventional open cholecystectomy should be performed without adequate perioperative antimicrobial prophylaxis in future, especially since such measures also reduce hospital stay and hence the costs.

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“…The effectiveness of perioperative antibiotic prophylaxis for elective and emergency interventions in visceral surgery has been sufficiently demonstrated by numerous studies and is the generally accepted norm [1, 2, 3, 5, 8, 9, 10]. When antibiotic prophylaxis is able to reduce post-operative infectious complications significantly, this always entails considerable savings in costs [4, 11].…”

Section: Discussionmentioning

confidence: 99%

Prospective Multicenter Study of Antibiotic Prophylaxis in Operative Treatment of Appendicitis

et al. 2000

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Background/Aims: A prospective, multicenter observation study was conducted to investigate the effectiveness of antibiotic prophylaxis in the operative treatment of appendicitis. Methods: Between June 1996 and May 1997, a total of 4,968 patients underwent an operation for appendicitis at 34 East German hospitals. 41.4% (n = 2,424) received perioperative antibiotic prophylaxis whereas in 58.9% of the cases this was not given. The patients who received antibiotic prophylaxis constituted a negative selection, both with regard to risk factors and to the stage of inflammation. Results: In the total test group, the rate for septic disorders of wound healing amounted to 2.5% (n = 120). The use of antibiotic prophylaxis makes it possible to significant lower the incidence of postoperative septic disorders of wound healing (p < 0.001). In both conventional (0.7% with prophylaxis vs. 3.8% without) and in laparoscopic appendectomy (0 vs. 1.0%) the rate for septic disorders of wound healing can be reduced (p < 0.001). The global comparison irrespective of possible antibiotic prophylaxis shows a significant advantage for appendectomies which started with laparoscopy (p = 0.008), but in the subgroups with prophylaxis this advantage is completely neutralized (p = 0.78). Conclusion: From this one can deduce that conventional appendectomy with antibiotic prophylaxis comprises no higher risk of wound infection than laparoscopy, since the risk of conversion exists for every operation begun by laparoscopy. These results would lead to the conclusion that antibiotic prophylaxis should be given before every appendectomy, whether by laparoscopy or conventional methods.

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Ceftriaxone versus clavulanate-potentiated amoxycillin for prophylaxis against post-operative sepsis in biliary surgery: A prospective randomized study in 200 patients

Cited by 12 publications

References 7 publications

Antibiotic Prophylaxis and Treatment of Surgical Abdominal Sepsis

Antibiotic Prophylaxis and Treatment of Surgical Abdominal Sepsis

Antimicrobial Prophylaxis in Laparoscopic and Conventional Cholecystectomy

Prospective Multicenter Study of Antibiotic Prophylaxis in Operative Treatment of Appendicitis

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