Cefuroxime: Potential Use in Pregnant Women at Term

Bousfield, P.; Browning, A. K.; Mullinger, Brenda; Elstein, Max

doi:10.1111/j.1471-0528.1981.tb00959.x

Cited by 21 publications

(20 citation statements)

References 2 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The highest levels of cefuroxime in plasma of pregnant patients with preterm premature rupture of the membranes, i h after intravenous injection of 1,500 mg cefuroxime, were similar to those of other investigators [13]. Also the plasma levels found 8 h after injection, and the levels in vaginal amniotic fluid were similar [13]. As expected, the amniotic fluid cefuroxime levels were higher than those reported by other investigators, who injected 750 mg cefuroxime intramuscularly or intravenously, or 1,000 mg cefuroxime intravenously [12 14-16].…”

Section: Pharmacokineticssupporting

confidence: 89%

“…The minimum and maximum levels were 9. The highest levels of cefuroxime in plasma of pregnant patients with preterm premature rupture of the membranes, i h after intravenous injection of 1,500 mg cefuroxime, were similar to those of other investigators [13]. Also the plasma levels found 8 h after injection, and the levels in vaginal amniotic fluid were similar [13].…”

Section: Pharmacokineticssupporting

confidence: 83%

“…One can suppose a homeostasis between the continuous excretion of cefuroxime by the foetal kidneys and its absorption by the membranes. The high cefuroxime levels in the membranes, which were higher than placental tissue levels and also higher than those found by other investigators, support supposition [13]. Yet, cefuroxime concentrations depend on the total volume of amniotic fluid.…”

Section: Pharmacokineticssupporting

confidence: 70%

“…Cefuroxime administration during spontaneous delivery or caesarean section at term, resulted in therapeutic concentrations in foetal blood and amniotic fluid, required for many common pathogens responsible for obstetrical infections [12][13][14][15][16]. However, cefuroxime levels in maternal plasma were significantly lower during pregnancy than during delivery or afterwards [16].…”

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Pharmacokinetics of cefuroxime in pregnant patients with preterm premature rupture of the membranes

Roumen¹,

Bouckaert²,

Cremers

et al. 1990

Pharmaceutisch Weekblad Scientific Edition

View full text Add to dashboard Cite

To 6 pregnant patients with preterm premature rupture of the membranes, cefuroxime prophylaxis was given 1,500 mg three times daily intravenously. Cefuroxime concentrations were assayed in maternal plasma and amniotic fluid during pregnancy and in umbilical cord blood, placenta, and membranes after delivery. Our results showed a high rate of transplacental transfer of cefuroxime. Bactericidal levels could be demonstrated in maternal plasma, and in amniotic fluid leaking from the vagina. Therapeutically active levels were present in the newborns. The absorption of cefuroxime by the foetal membranes was high. Although the neonatal morbidity in this high-risk population was low, the data are still too preliminary to advise the routine prophylactic use of cefuroxime to pregnant patients with preterm premature rupture of the membranes.

show abstract

Section: Pharmacokineticssupporting

confidence: 89%

Section: Pharmacokineticssupporting

confidence: 83%

Section: Pharmacokineticssupporting

confidence: 70%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Pharmacokinetics of cefuroxime in pregnant patients with preterm premature rupture of the membranes

Roumen¹,

Bouckaert²,

Cremers

et al. 1990

Pharmaceutisch Weekblad Scientific Edition

View full text Add to dashboard Cite

show abstract

“…Bousfleld et al reported comparable data, with intravenous injections of 1,500 mg cefuroxime every 4 h until delivery [23]. After one dose, the concentration in the amniotic fluid ranged from 0 to 43.4/zg/ml, 6 and 34/zg/ml after 2 injections and 77.8 /~g/ml after 3 injections.…”

Section: Pregnancymentioning

confidence: 63%

Pharmacokinetics and tissue concentrations of cefuroxime

Vree¹

1990

Pharmaceutisch Weekblad Scientific Edition

View full text Add to dashboard Cite

Cefuroxime is well-absorbed and distributed over the human body. This review gives a general summary of published information on tissue concentrations of cefuroxime after an intravenous or intramuscular dose of 750 or 1,500 mg of cefuroxime. Tissue concentrations are given for blister fluid, meninges, eyes, respiratory tract, sputum and bronchi, abdominal and urogenital tract, uterine, ovarian and fallopian tube tissue, myometrium, membranes, placenta, puruloid and healthy human milk, bile, prostate, hip and knee bone. Pharmacokinetics are reviewed in patients with impaired kidney function and in pregnancy.

show abstract

Preliminary physiologically based pharmacokinetic modeling of renally cleared drugs in Chinese pregnant women

Lee

et al. 2020

Biopharm & Drug Disp

View full text Add to dashboard Cite

AimThe aim of this study was to build and verify a preliminary physiologically based pharmacokinetic (PBPK) model of Chinese pregnant women. The model was used to predict maternal pharmacokinetics (PK) of 6 predominantly renally cleared drugs.MethodBased on SimCYP Caucasian pregnancy population dataset, the preliminary Chinese pregnant population was built by updating several key parameters and equations according to physiological parameters of Chinese (or Japanese) pregnant women. Drug‐specific parameters of 6 renally cleared drugs were validated through PBPK modeling of Caucasian non‐pregnant, Caucasian pregnant and Chinese non‐pregnant population. The preliminary PBPK model of Chinese pregnant population was then developed by integrating the preliminary Chinese pregnant population and the drug‐specific parameters. This model was verified by comparing the predicted maternal PK of these 6 drugs with the observed in vivo data from the literature.ResultsThe preliminary Chinese pregnant population PBPK model successfully predicted the PK of 6 target drugs for different pregnancy stages. The predicted plasma concentrations time profiles fitted the observed data well, and most predicted PK parameters were within 2‐fold of observed data. Conclusions: The preliminary Chinese pregnant population PBPK model provided a useful tool to predict the maternal PK of 6 predominantly renally cleared drugs in Chinese pregnant women.

show abstract

Cefuroxime: Potential Use in Pregnant Women at Term

Cited by 21 publications

References 2 publications

Pharmacokinetics of cefuroxime in pregnant patients with preterm premature rupture of the membranes

Pharmacokinetics of cefuroxime in pregnant patients with preterm premature rupture of the membranes

Pharmacokinetics and tissue concentrations of cefuroxime

Preliminary physiologically based pharmacokinetic modeling of renally cleared drugs in Chinese pregnant women

Contact Info

Product

Resources

About