Celastrol and Melatonin Modify SIRT1, SIRT6 and SIRT7 Gene Expression and Improve the Response of Human Granulosa-Lutein Cells to Oxidative Stress

Martín-Ramírez, Rita; González-Fernández, Rebeca; Hernández, Jairo; Martín‐Vasallo, Pablo; Palumbo, Angela; Ávila, Julio

doi:10.3390/antiox10121871

Cited by 15 publications

(8 citation statements)

References 58 publications

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“…The sirtuin family consists of seven proteins (encoded by the genes SIRT1, SIRT2, SIRT3, SIRT4, SIRT5, SIRT6, and SIRT7), which deacetylate histones in a nicotinamide adenine dinucleotide (NAD + )-dependent manner and which are involved in the repair of damaged DNA, too [ 7 ]. In addition, the expression of sirtuins can be increased by supplementing a stilbene derivative, i.e., resveratrol, melatonin, astaxanthin, celastrol, or mogroside [ 8 , 9 , 10 , 11 ]. The activators presented have been touted for improving oocyte quality or reversing the effects of oxidative stress, and some, such as melatonin, have been proposed as candidates for the composition of media in in vitro cultures.…”

Section: Introductionmentioning

confidence: 99%

Resveratrol and SIRT1: Antiaging Cornerstones for Oocytes?

Grzeczka

Kordowitzki

2022

Nutrients

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It is well-known that there is an enormous variability in the aging-related decline of oocytes’ quantity and their developmental competence among mammalian species. The implication of female germline aging is profound from the perspective of evolutionary conservation of the aging mechanism, a topic of continuous and widespread interest that has yet to be fully addressed for the mammalian oocyte. There is a certain need to develop novel antiaging strategies to delay or slow down aging, or even to reverse the aging phenotype in the oocyte. In the past two decades, several antioxidants have been tested for this purpose. Resveratrol is one of these latter-mentioned compounds, which has shown anti-inflammatory and antiaging properties in a dose-dependent manner. Interestingly, resveratrol appears to enhance the activity of so-called Sirtuin 1, too. Therefore, the aim of this review is to summarize and discuss the latest findings related to resveratrol, Sirtuin 1, and their crosstalk and influence on the mammalian oocyte to elucidate the question of whether these factors can delay or slow down reproductive aging.

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Section: Introductionmentioning

confidence: 99%

Resveratrol and SIRT1: Antiaging Cornerstones for Oocytes?

Grzeczka

Kordowitzki

2022

Nutrients

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“…Specifically, natural compounds 1 , 3 , − 4 , , 5 , 8 , , 9 , and drug 11 , demonstrate the capability to also activate SIRT1. Compound 7 exhibits the direct induction of the SIRT7 gene expression, whereas compound 13 elicits the expression of SIRT1, SIRT6, and SIRT7 . However, all these compounds ( 1 – 15 ) could be considered potential lead compounds to be optimized through a med-chem approach.…”

Section: Sirt3 Positive Modulatorsmentioning

confidence: 99%

“…Compound 7 exhibits the direct induction of the SIRT7 gene expression, whereas compound 13 elicits the expression of SIRT1, SIRT6, and SIRT7. 264 However, all these compounds ( 1 – 15 ) could be considered potential lead compounds to be optimized through a med-chem approach.…”

Section: Sirt3 Positive Modulatorsmentioning

confidence: 99%

SIRT3 Activation a Promise in Drug Development? New Insights into SIRT3 Biology and Its Implications on the Drug Discovery Process

Lambona,

Zwergel,

Valente

et al. 2024

J. Med. Chem.

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Sirtuins catalyze deacetylation of lysine residues with a NAD + -dependent mechanism. In mammals, the sirtuin family is composed of seven members, divided into four subclasses that differ in substrate specificity, subcellular localization, regulation, as well as interactions with other proteins, both within and outside the epigenetic field. Recently, much interest has been growing in SIRT3, which is mainly involved in regulating mitochondrial metabolism. Moreover, SIRT3 seems to be protective in diseases such as age-related, neurodegenerative, liver, kidney, heart, and metabolic ones, as well as in cancer. In most cases, activating SIRT3 could be a promising strategy to tackle these health problems. Here, we summarize the main biological functions, substrates, and interactors of SIRT3, as well as several molecules reported in the literature that are able to modulate SIRT3 activity. Among the activators, some derive from natural products, others from library screening, and others from the classical medicinal chemistry approach. ■ SIGNIFICANCESirt3 is an epigenetic target from the family sirtuins deacetylases with rapidly growing interest in age-related, neurodegenerative, liver, kidney, heart, and metabolic diseases, as well as in cancer. Its high relevance in numerous diseases is attracting medicinal chemists to develop activators, as Sirt3 activation is associated with beneficial effects to tackle the mentioned health problems. The present perspective is shedding light on the recent findings and potential developments regarding Sirt3 from a medchem viewpoint.

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“…SIRTs regulate metabolism, energy expenditure, and the aging process which, in turn, are regulated by diet and environmental stress [25][26][27][28]. SIRTs are found in the GCs of various mammalian species including humans at different stages of the reproductive cycle [21,[29][30][31][32][33][34][35].…”

Section: Introductionmentioning

confidence: 99%

Divergent roles of sirtuin 1 in human granulosa-lutein cells: similarities to human chorionic gonadotropin

Meidan

Szymańska

2023

Biology of Reproduction

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Sirtuin 1 (SIRT1) is an NAD+ dependent deacetylase that modifies gene expression through histone deacetylation. It also deacetylates non-histone substrates, e.g. tumor suppressor p53, NOS3, HIF1A, NFKB, FOXO3a, PGC-1α, and PPARγ. Consequently, it regulates a wide range of physiological functions including cell cycle control, energy expenditure, oxidative stress response, apoptosis, and aging. SIRT1 is expressed in ovarian granulosa cells (GCs) of various species including humans at different stages of the reproductive cycle. The importance of SIRT1 in female reproduction is supported by the findings that SIRT1-knockout mice exhibit defects in reproductive tissue development. These mice were found to have a thin-walled uterus, small ovaries, with follicles present but no corpora lutea. This review aims to provide state-of-the-art information on SIRT1’s mode of action and its roles in human granulosa-lutein cells and GCs from other species where data is available. It also discusses the overlapping actions of SIRT1 and hCG on the production of critical GC-borne factors.

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Celastrol and Melatonin Modify SIRT1, SIRT6 and SIRT7 Gene Expression and Improve the Response of Human Granulosa-Lutein Cells to Oxidative Stress

Cited by 15 publications

References 58 publications

Resveratrol and SIRT1: Antiaging Cornerstones for Oocytes?

Resveratrol and SIRT1: Antiaging Cornerstones for Oocytes?

SIRT3 Activation a Promise in Drug Development? New Insights into SIRT3 Biology and Its Implications on the Drug Discovery Process

Divergent roles of sirtuin 1 in human granulosa-lutein cells: similarities to human chorionic gonadotropin

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