Celastrol functions as an emerging manager of lipid metabolism: Mechanism and therapeutic potential

Gu, Jun; Shi, Yaning; Zhu, Neng; Li, Hongfang; Zhang, Chanjuan; Qin, Li

doi:10.1016/j.biopha.2023.114981

Cited by 7 publications

(2 citation statements)

References 112 publications

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“…Tyloxapol is a well-known agent to induce hyperlipidemia in animal model. 47 Otway and Robinsons 43 have stated that the large increase in serum cholesterol and triglycerides by tyloxapol resulted mostly from an increase of VLDL secretion by the liver, accompanied by a strong reduction of VLDL-C and LDL-C catabolism. In our Swiss albino mice also, it could significantly increase the serum lipid levels exhibiting its hyperlipidemic properties.…”

Section: Discussionmentioning

confidence: 99%

Role of flower extract in preventing hyperlipidemia and liver lipid peroxidation in male mice

Kar,

J Jha,

Mahar

2024

IJPP

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: Hyperlipidemia leads to coronary artery disease. Although statins are used conventionally, they are often associated with side effects. It has now been attempted to study the role of flower (MOF) extract in the regulation of tyloxapol-induced hyperlipidemia and tissue lipid peroxidation (LPO) in male mice.Six groups of animals were taken. Group I acted as control and group II, receiving tyloxapol (300 mg/kg, single dose on 14 day) served as hyperlipidemic control. Group III received simvastatin (200 mg/kg), while group IV, V and VI received MOF extract at 400, 200 and 100 mg/kg every day respectively for 15 days. These four groups (III- VI) also received same amount of tyloxapol on 14 day. On day 16 changes in the serum total cholesterol, triglycerides, high-density lipoprotein, low-density lipoprotein and very low-density lipoprotein; hepatic LPO, super oxide dismutase, catalase, glutathione peroxidase and histological changes in liver were analyzed. Total phenolic and flavonoid contents were also estimated. The in-vitro antioxidative property was checked through DPPH and HO assays.: Results showed significant reduction in all the serum lipids except HDL, which was increased in MOF treated hyperlipidemic mice, with the parallel decrease in hepatic LPO and increase in antioxidants. Histological studies also showed reduction in hepatic damage with the pre-treatment of MOF. However, the most effective dose was found to be 400 mg/kg of MOF. : We suggest that flower extract may ameliorate hyperlipidemia with antioxidative benefits.

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Section: Discussionmentioning

confidence: 99%

Role of flower extract in preventing hyperlipidemia and liver lipid peroxidation in male mice

Kar,

J Jha,

Mahar

2024

IJPP

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“…However, its direct clinical use has been limited by its poor water solubility and marked toxicity. 355,356 To circumvent these challenges, Ding et al innovatively encapsulated celastrol into SF nanoparticles (CL-SFNPs) using a modified desolvation method and found that CL-SFNPs outperformed free-form celastrol in terms of antitumor efficacy, inhibition of colony formation, and induction of cancer cell apoptosis. 354 Thus, these findings highlight the potential of SFNPs to act as a delivery platform for celastrol to advance cancer therapies.…”

Section: Drug Repurposing: Candidates For Nanomaterial-based Therapymentioning

confidence: 99%

Drug repurposing for cancer therapy

Xia,

Sun,

Huang

et al. 2024

Sig Transduct Target Ther

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Cancer, a complex and multifactorial disease, presents a significant challenge to global health. Despite significant advances in surgical, radiotherapeutic and immunological approaches, which have improved cancer treatment outcomes, drug therapy continues to serve as a key therapeutic strategy. However, the clinical efficacy of drug therapy is often constrained by drug resistance and severe toxic side effects, and thus there remains a critical need to develop novel cancer therapeutics. One promising strategy that has received widespread attention in recent years is drug repurposing: the identification of new applications for existing, clinically approved drugs. Drug repurposing possesses several inherent advantages in the context of cancer treatment since repurposed drugs are typically cost-effective, proven to be safe, and can significantly expedite the drug development process due to their already established safety profiles. In light of this, the present review offers a comprehensive overview of the various methods employed in drug repurposing, specifically focusing on the repurposing of drugs to treat cancer. We describe the antitumor properties of candidate drugs, and discuss in detail how they target both the hallmarks of cancer in tumor cells and the surrounding tumor microenvironment. In addition, we examine the innovative strategy of integrating drug repurposing with nanotechnology to enhance topical drug delivery. We also emphasize the critical role that repurposed drugs can play when used as part of a combination therapy regimen. To conclude, we outline the challenges associated with repurposing drugs and consider the future prospects of these repurposed drugs transitioning into clinical application.

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Crosstalk between ROS-inflammatory gene expression axis in the progression of lung disorders

Ashique,

Mishra,

Mantry

et al. 2024

Naunyn-Schmiedeberg's Arch Pharmacol

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Celastrol functions as an emerging manager of lipid metabolism: Mechanism and therapeutic potential

Cited by 7 publications

References 112 publications

Role of flower extract in preventing hyperlipidemia and liver lipid peroxidation in male mice

Role of flower extract in preventing hyperlipidemia and liver lipid peroxidation in male mice

Drug repurposing for cancer therapy

Crosstalk between ROS-inflammatory gene expression axis in the progression of lung disorders

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