Celastrol Prevents Adverse Cardiac Remodeling of the Ischemic Myocardium

DerSarkissian, S.; Cailhier, J.; Borie, M.; Stevens, Laura; Gaboury, Louis; Mansour, Samer; Noiseux, N.

doi:10.1016/j.cjca.2014.07.076

Cited by 3 publications

(3 citation statements)

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“…Another mechanism of interest involves the HO-1 and HSF1/HO-1 pathways [ 16 , 17 ]. These studies investigated the role of HO-1 expression in ischemic myocardium attenuation.…”

Section: Reviewmentioning

confidence: 99%

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The Promising Therapeutic Potential of Celastrol for Fibrotic Diseases: A Systematic Literature Review on Its Mechanism

Mohd Khairudin,

Azme,

Nasrudin

et al. 2023

Cureus

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Celastrol is a pentacyclic tripterine sourced from Tripterygium wilfordii hook root. Celastrol can exert certain biological functions such as antitumor, anti-inflammatory, and antiproliferative properties. Celastrol was shown from the previous literature to be capable of attenuating many fibrotic diseases. As the effects of various fibrotic diseases such as atherosclerosis, cancer, and ischemia affect more people with devastating repercussions, this warrants celastrol to be exploited as a phytotherapeutic drug. The purpose of this study is to review previous research and identify the proposed therapeutic mechanisms of celastrol in fibrotic diseases focusing on both the in vitro and in vivo experimental models. A systematic literature search on Web of Science (WoS), Scopus, and ScienceDirect that included articles published between 2012 and 2022 was carried out using the keywords “celastrol”, “tripterine”, “fibrotic disease”, and “fibrosis”. After screening the initial search yield of 405 articles, 25 articles were included in this review. The study findings summarize the potential therapeutic mechanism of celastrol in the attenuation of fibrotic diseases in in vivo and in vitro experimental models. It shows that celastrol is useful as a treatment means. However, more studies are needed on the effects of celastrol on humans to carry out clinical trials to verify the long-term benefits of celastrol.

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“…Another mechanism of interest involves the HO-1 and HSF1/HO-1 pathways [ 16 , 17 ]. These studies investigated the role of HO-1 expression in ischemic myocardium attenuation.…”

Section: Reviewmentioning

confidence: 99%

“…A follow-up study indicated that the involved HSR was HSF1. Celastrol promotes cell survival through HSF1 activation coupled with HO-1 upregulation, thus exhibiting anti-fibrotic effects [ 17 ].…”

Section: Reviewmentioning

confidence: 99%

The Promising Therapeutic Potential of Celastrol for Fibrotic Diseases: A Systematic Literature Review on Its Mechanism

Mohd Khairudin,

Azme,

Nasrudin

et al. 2023

Cureus

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“…Celastrol (1), a quinone methide triterpenoid extracted from the root bark of the traditional Chinese medicine "Thunder of God", has been used traditionally for the treatment of various diseases such as inflammation, joint pain, edema, chills, and rheumatoid arthritis. [1][2][3][4][5][6] Celastrol shows a great variety of biological effects such as anti-oxidant, 7,8 anti-tumor, [9][10][11][12] anti-obesity, 13,14 cardiac protection, 15,16 anti-inflammatory [17][18][19] and antiangiogenic 20,21 activities, in both in vitro and in vivo models. It exhibits astonishing clinical potential as a therapeutic and chemopreventive agent toward various cancers.…”

Section: Introductionmentioning

confidence: 99%

Advances in structural modifications of celastrol

Cai¹,

Jin²,

He³

2016

Arkivoc

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Celastrol, a quinone methide triterpenoid from the Chinese medicinal root bark of Tripterygium wilfordii, possesses beneficial therapeutic properties and affects numerous cellular pathways. Recently, structure and activity relation studies based on celastrol semi-synthetic derivatives have contributed greatly to our understanding of its mechanism of action and cellular targets. These modifications have resulted in better activity and improvement of the pharmacokinetic properties of celastrol. This review will mainly cover advances in the structural modifications of celastrol at the C-20 carboxylic acid functionality, alterations of the A ring, and modifications at C-6.

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