Celdoprostatitis incrustante por Corynebacterium urealyticum: la importancia de la sospecha clínica

Preliminary In Vitro Studies on Corynebacterium urealyticum Pathogenetic Mechanisms, a Possible Candidate for Chronic Idiopathic Prostatitis?

“…Although a wide variety of coryneform bacteria have been found from the male genital tract of prostatitis patients [32][33][34][35][36], only one clinical case of prostatitis caused by C. urealyticum has been reported [8]. These data seemed underestimated, and led to questioning as to whether C. urealyticum could be one of the causative agents of chronic prostatitis.…”

“…Unfortunately, in the case of encrusted cystitis as well as prostatitis, antibiotic therapy alone is ineffective; indeed, in order to properly eradicate the bacterium, in addition to specific antibiotic treatment, it is essential to eliminate calcifications [8]. In this context, our study has brought new pieces of evidence on the therapeutical use of the irreversible urease inhibitors such as AHA, not only as enzyme blockers to facilitate the removal of encrustations, but also as modulators of some pathogenic mechanisms.…”

“…An initial examination of the urine revealed an E. coli infection with an alkaline pH, with only the microbiological analysis of the pathological prostate tissue revealing infection by C. urealyticum. In addition, in this case, the authors pointed out the difficulty of a correct diagnosis for the C. urealyticum infection due to its slow growth and the challenge of identification and in vitro isolation [8].…”