Celecoxib ameliorates liver cirrhosis via reducing inflammation and oxidative stress along spleen-liver axis in rats

Tang, Shihang; Huang, Zhiyin; Jiang, Jingsun; Gao, Jinhang; Zhao, Chong; Tai, Yang; Ma, Xiao; Zhang, Linhao; Ye, Yanting; Chai, Guoqiang; Wei, Su; Jia, Xintong; Liu, Rui; Wu, Hao; Tang, Chengwei

doi:10.1016/j.lfs.2021.119203

Cited by 17 publications

(11 citation statements)

References 36 publications

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“…However, NLRP3 inflammasome-derived IL-1β secretion and pyroptosis in macrophages and collagens deposition were blocked by pharmaceutical inhibition or genetic knockdown of COX-2 ( 84 ). Consistently, COX-2 promotes the development of liver cirrhosis ( 85 ) by inducing ROS ( 86 , 87 ) and ER stress ( 88 ), indicating that COX-2 might contribute to liver cirrhosis via macrophage-derived inflammasomes. However, further studies are needed to determine how COX-2 regulates the activation of macrophage-derived inflammasomes and pyroptosis of macrophages in the context of liver fibrosis.…”

Section: Inflammasome and Pyroptosis In Liver Fibrosismentioning

confidence: 87%

Inflammasomes and Pyroptosis of Liver Cells in Liver Fibrosis

et al. 2022

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Inflammasomes are multiprotein complexes that can sense danger signals and activate caspase-1 to mediate pro-inflammatory cytokines release and pyroptotic cell death. There are two main canonical and non-canonical signaling pathways that trigger inflammasome activation. Inflammasomes are expressed and assembled in parenchymal and nonparenchymal cells in response to liver injury in the liver. Additionally, the hepatocytes, biliary epithelial cells (cholangiocytes), hepatic stellate cells (HSCs), hepatic macrophages, and liver sinusoidal endothelial cells (LSECs) contribute to liver fibrosis via different mechanisms. However, the underlying mechanism of the inflammasome and pyroptosis in these liver cells in liver fibrosis remains elusive. This review summarizes the activation and function of inflammasome complexes and then discusses the association between inflammasomes, pyroptosis, and liver fibrosis. Unlike other similar reviewers, we will focus on the effect of inflammasome activation and pyroptosis in the various liver cells during the development of liver fibrosis. We will also highlight the latest progress of pharmacological intervention in inflammasome-mediated liver fibrosis.

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Section: Inflammasome and Pyroptosis In Liver Fibrosismentioning

confidence: 87%

Inflammasomes and Pyroptosis of Liver Cells in Liver Fibrosis

et al. 2022

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“…When it is damaged by congenital or acquired reasons, it causes immune deficiency, which lead to a series of diseases, such as failure to thrive, generalized erythematous rash, and recurrent gastrointestinal and respiratory tract infections, including episodes of Pneumocystis pneumonia infection and Candida albicans fungemia ( Somekh et al, 2021 ) , and inflammation is the most common symptom of these diseases. Inflammation is a kind of disease of the immune system ( Garrett, Gordon, & Glimcher, 2010 ), that occurs early in the course of many diseases, such as diabetes ( Sun et al, 2020 ), cancer ( Watanabe et al, 2021 ), and liver cirrhosis ( Tang et al, 2021 ). Although the inflammation produced is a beneficial self-protective immune response, body may also attack its own tissues sometimes due to excessive inflammation ( Zhang et al, 2020 , Zhang et al, 2020 ).…”

Section: Introductionmentioning

confidence: 99%

Dendrobium officinale leaf polysaccharides regulation of immune response and gut microbiota composition in cyclophosphamide-treated mice

et al. 2022

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“…A therapeutic argument for the inflammation theory in liver cirrhosis was that, in a laboratory study, the administration of celecoxib reduced the carbon tetrachloride-induced liver fibrosis in mice (15).…”

Section: Resultsmentioning

confidence: 99%

CRP and the Prognosis of Patients with Cirrhosis

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2021

Maedica

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The theory of vasodilation partially explains the development and progression of liver cirrhosis and is completed by the theory of inflammation. C-reactive protein (CRP) is used as a surrogate marker of inflammation in studies; however, there is not sufficient data that would reflect the role of this protein in cirrhosis yet.The objective of this study was to determine the use of CRP value in the prognosis of patients with cirrhosis.In "Material and method" section we described a clinical prospective trial with 102 participants represented by patients with cirrhosis of various etiologies in a tertiary hospital, each monitored throughout a period of 12 months after the collection of CRP.The results showed that the mean CRP value was 0.7+/0.09 mg/dL (CI 0.59-0.90) in patients who did not decompensate throughout the trial and 1.58+/0.4 mg/dL (CI 1.76-2.30) in those who did decompensate, with a statistically significant difference (p=0.045).In rehospitalized patients versus those without any hospitalization, the mean CRP values were 1.35 mg/dL and 0.8 mg/dL, respectively (p=0.032). The increased values of this parameter were positively correlated with the number of hospitalizations (rs=0.35, p=0.05).A CRP value below the threshold of 0.62 mg/dL indicates a smaller probability of future decompensation in liver cirrhosis patients.The conclusion of this study is that CRP influences the secondary endpoints, including cirrhosis decompensation and patient rehospitalization. It can be added to the existing studies.

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Celecoxib ameliorates liver cirrhosis via reducing inflammation and oxidative stress along spleen-liver axis in rats

Cited by 17 publications

References 36 publications

Inflammasomes and Pyroptosis of Liver Cells in Liver Fibrosis

Inflammasomes and Pyroptosis of Liver Cells in Liver Fibrosis

Dendrobium officinale leaf polysaccharides regulation of immune response and gut microbiota composition in cyclophosphamide-treated mice

CRP and the Prognosis of Patients with Cirrhosis

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