Celery-based topical repellents as a potential natural alternative for personal protection against mosquitoes

Tuetun, Benjawan; Choochote, Wej; Pongpaibul, Yanee; Junkum, Anuluck; Kanjanapothi, Duangta; Chaithong, Udom; Jitpakdi, Atchariya; Riyong, Doungrat; Pitasawat, Benjawan

doi:10.1007/s00436-008-1167-1

Cited by 25 publications

(35 citation statements)

References 16 publications

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“…Repellency that derived from the most effective repellent, 25 % of hexane-extracted A. graveolens with the addition of 5 % vanillin, was comparable to the value obtained from 25 % of DEET with 5 % vanillin added. Chemical identification by gas chromatography coupled with mass spectrometry discovered that the major constituents of Apium graveolens hexane extract (AHE) were 3-n-butyl-tetrahydrophthalide (92.48 %), followed by 5.10 % beta-selinene and 0.68 % gamma-selinene (Tuetun et al 2008). The best AHE-developed product provided remarkable repellency with a median protection time of 4.5 h (4.5-5 h), which was greater than that of ethanolic DEET solution (25 % DEET, 3.5 h) and comparable to that of the best commercial repellent, Insect Block 28 (28.5 % DEET, 4.5 h).…”

Section: Insect Repellencymentioning

confidence: 99%

Celery Seed and Related Extracts with Antiarthritic, Antiulcer, and Antimicrobial Activities

Powanda¹,

Whitehouse

Rainsford

2015

Progress in Drug Research

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Celery preparations have been used extensively for several millennia as natural therapies for acute and chronic painful or inflammatory conditions. This chapter reviews some of the biological and chemical properties of various celery preparations that have been used as natural remedies. Many of these have varying activities and product qualities. A fully standardized celery preparation has been prepared known as an alcoholic extract of the seeds of a plant source derived from northern India. This is termed, Celery Seed Extract (CSE) and has been found to be at least as effective as aspirin, ibuprofen, and naproxen in suppressing arthritis in a model of polyarthritis. CSE can also reduce existing inflammation in rats. CSE has also been shown to provide analgesia in two model systems. CSE, in addition to acting as an analgesic and inflammatory agent, has been shown to protect against and/or reduce gastric irritation caused by NSAIDs, as well as act synergistically with them to reduce inflammation. The CSE was fractionated by organic solvent extractions, then subjected to column chromatography followed by HPLC and was characterized by mass spectrometry. This yielded a purified component that had specific inhibitory effects on Helicobacter pylori but was not active against Campylobacter jejuni or Escherichia coli. Additionally, toxicology studies did not reveal any clear signs of toxicity at doses relevant to human use. Also, unlike many dietary supplements, the available data suggest that CSE does not significantly affect the p450 enzyme systems and thus is less likely to alter the metabolism of drugs the individual may be taking. CSE may be a prototype of a natural product that can be used therapeutically to treat arthritis and other inflammatory diseases.

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Section: Insect Repellencymentioning

confidence: 99%

Celery Seed and Related Extracts with Antiarthritic, Antiulcer, and Antimicrobial Activities

Powanda¹,

Whitehouse

Rainsford

2015

Progress in Drug Research

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“…NBP is one of the active constituents in celery. [24][25][26] Some researchers have reported antihypertensive effects of some FIG. 3.…”

Section: Discussionmentioning

confidence: 99%

Antihypertensive Effect of Celery Seed on Rat Blood Pressure in Chronic Administration

Moghadam

Imenshahidi

Mohajeri

2013

Journal of Medicinal Food

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This study investigated the effects of different celery (Apium graveolens) seed extracts on blood pressure (BP) in normotensive and deoxycorticosterone acetate-induced hypertensive rats. The hexanic, methanolic, and aqueous-ethanolic extracts were administered intraperitoneally and their effects on BP and heart rate (HR) were evaluated in comparison with spirnolactone as a diuretic and positive control. Also, the amount of n-butylphthalide (NBP), as an antihypertensive constituent, in each extract was determined by HPLC. The results indicated that all extracts decreased BP and increased the HR in hypertensive rats, but had no effect on normotensive rats. The data showed that administration of 300 mg/kg of hexanic, methanolic, and aqueous-ethanolic (20/80, v/v) extracts of the celery seed caused 38, 24, and 23 mmHg reduction in BP and 60, 25, and 27 beats per minute increase in the HR, respectively. Also, the HPLC analysis data revealed that the content of NBP in the hexanic extract was 3.7 and 4 times greater than methanolic and aqueous-ethanolic extracts. It can be concluded that celery seed extracts have antihypertensive properties, which appears to be attributable to the actions of its active hydrophobic constitutes such as NBP and can be considered as an antihypertensive agent in chronic treatment of elevated BP.

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“…Celery ( A. graveolens ) is an outstanding plant which possesses various kinds of bioactivities against mosquitoes, including repellent, larvicidal, and adulticidal effects Tuetun et al 2004Tuetun et al , 2005Tuetun et al , 2008Tuetun et al , 2009Trongtokit et al 2005 ;Chaiyasit et al 2006 ;Pitasawat et al 2007 ). However, the repellent activity of celery seed extract seems to be an extraordinary effect over other activities.…”

Section: Repellentsmentioning

confidence: 98%

“…It is noteworthy that G10 showed excellent repellency against Ae. aegypti in laboratory (Tuetun et al 2008 ) and against a wide range of mosquito species belonging to various genera, including Aedes , Anopheles , Armigeres , Culex , and Mansonia in the fi eld (Tuetun et al 2009 ). It is expected that G10 will be commercial available in Thailand in the near future.…”

Section: Repellentsmentioning

confidence: 99%

Role of Plant Biopesticides in Managing Vectors of Communicable Diseases

Tawatsin

Thavara

Siriyasatien

et al. 2014

Advances in Plant Biopesticides

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Some insects and arthropods frequently pose a serious risk to human health. They can cause painful bites and transmit some pathogens causing serious diseases such as malaria, dengue hemorrhagic fever, lymphatic fi lariasis, Lyme disease, river blindness, etc. Since the protective vaccines have not yet been available for most of these vector-borne diseases, vector controls are therefore the main strategies to prevent the diseases. Such plant-based products have been used in the control of insects of public health importance for centuries. However, the development and use of phytochemicals attracted considerable attention from researchers and industrial concerns in the last quarter of the century. Examples of major plant-based products used in pest control are pyrethrins, neem constituents, as well as many plant volatile essential oils for repelling hematophagous insects affording personal protection of humans from biting arthropods and noxious insects. The public has the perception that plantbased and other natural products are environmentally friendly and safer to use for vector control or apply to human skin as personal protectants than synthetic chemicals. Considerable advances have then been made in formulating phytochemicals to increase their effi cacy, providing protection and acceptability in public health. In this chapter, we will dwell upon the research and development efforts leading to the development and use of plant essential oils for personal protection from anthropophilic insects and arthropods as well as the development and application of phytochemicals for the control of adult and preimaginal stages of disease vectors.

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Celery-based topical repellents as a potential natural alternative for personal protection against mosquitoes

Cited by 25 publications

References 16 publications

Celery Seed and Related Extracts with Antiarthritic, Antiulcer, and Antimicrobial Activities

Celery Seed and Related Extracts with Antiarthritic, Antiulcer, and Antimicrobial Activities

Antihypertensive Effect of Celery Seed on Rat Blood Pressure in Chronic Administration

Role of Plant Biopesticides in Managing Vectors of Communicable Diseases

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