Celestrol-Loaded Nanoscale Micelles Derived from Dextran Sulfate/PVGLIG/Celestrol with MMP-2 Sensitivity for the Treatment of High-Fat-Diet-Induced Obesity

Chen, Qiang; Guo, Caixia; Guo, Huimin; Su, Yanguo; Liu, Zhongxin; Cao, Min; Chen, Daquan

doi:10.1021/acsanm.2c02956

Cited by 7 publications

(1 citation statement)

References 36 publications

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“…The fat liver comorbidity symptoms were significantly alleviated, and little weight regain was associated after treatments. Compared with the previously reported obesity treatment efficacies that were achieved via regulation of signal pathway for fat metabolism, immune regulation, reprogramming of intestine microbiota, browning white adipocytes or photothermal ablation, the weight loss achieved via current strategy of camouflaging adipocytes with apoptotic feature is remarkable (33.3%) and comparable with the efficacy achieved by the well‐known counterpart, such as pro‐apoptosis peptide KLA (≈30%), [ 19 ] celastrol (≈54%), [ 54 ] rosiglitazone (≈15%), [ 13 ] capsaicin (22.4%), [ 55 ] photothermal agents (≈15% for Copper sulfide hydrogel), [ 56 ] and etc. (Table S1, Supporting Information).…”

Section: Discussionmentioning

confidence: 82%

Gold Nanobipyramid‐Mediated Apoptotic Camouflage of Adipocytes for Obesity Immunotherapy

Yan

Wang

et al. 2022

Advanced Materials

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Obesity treatment is a global public health challenge due to inadequate weight loss and weight regain even after endeavors with multimodal treatments. Considering the abundance of resident macrophages in adipose tissues, precise regulation of the interactions between macrophages and adipocytes may provide chances for immunotherapy of obesity. Herein, inspired by the phagocytosis of macrophages to clear apoptotic cells in homeostasis, an immunotherapy strategy for obesity treatment is proposed for the first time through apoptotic camouflage of adipocytes by PAAu BPs to activate macrophages for clearance, where PAAu BPs are gold nanobipyramids engineered with adipose‐targeting and apoptotic cell‐mimicking functions. During clearance, the macrophage is switched from pro‐inflammatory M1 to anti‐inflammatory M2, remarkably modulating the immune microenvironment of adipose tissues to prevent weight regain. After inguinal injection with PAAu BPs, the body weights of obese mice are effectively decreased by 24.4% and can be decreased by 33.3% when combined with photothermal lipolysis, and little weight regain is associated with these treatments. This study demonstrates that the strategy of camouflaging adipocytes with apoptotic features holds great potential for obesity immunotherapy.

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Section: Discussionmentioning

confidence: 82%

Gold Nanobipyramid‐Mediated Apoptotic Camouflage of Adipocytes for Obesity Immunotherapy

Yan

Wang

et al. 2022

Advanced Materials

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Heavily Labeled Signal Probe for Electrogenerated Chemiluminescence Peptide‐Based Biosensing of Matrix Metalloproteinase 2

Zhang,

Qian,

Yang

et al. 2024

Chemistry An Asian Journal

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The field of electrogenerated chemiluminescence (ECL) biosensing has witnessed remarkable growth, emphasizing the need for precise detection of biomarkers. The synthesis approach of peptide‐based signal probe with high recognition ability and high ECL efficiency is a significant issue in the ECL biosensing. Here, a heavily labeled signal probe was synthesized for ECL peptide‐based biosensing tactic by using a new aldehyde bearing cyclometalated Ir(III) complex ([Ir(bt)2(bpy‐CHO)PF6 (bt=2‐phenylbenzothiazole, bpy‐CHO=4’‐methyl‐[2,2’‐bipyridine]‐4‐carbaldehyde, denoted as Ir1) as ECL signal reagent and streptavidin (SA) as carrier protein. One ECL peptide‐based biosensing method was exemplified for the detection of matrix metalloproteinase 2 (MMP‐2) by using Ir1 labeled SA (SA−Ir1) as heavily labeled signal probe and biotinylated peptide as molecular recognition substrate. MMP‐2 was sensitively detected in the range from 5 to 100 ng/mL with a detection limit of 1.5 ng/mL. Importantly, two detection modes differing in the order of cleavage recognition by MMP‐2 and signal transduction with SA−Ir1 were compared for the first time. First cleavage and second signal transduction were proposed to be beneficial to sensitive detection of target, which provides some ideas for biomarker diagnostics in disease screening at an early stage.

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Recent Advances in the Anti‐Obesity Benefits of Phytoconstituents: From Phytochemistry to Targeting Novel‐Systems

Xian,

Huang,

Bai

et al. 2024

Phytotherapy Research

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Obesity is a metabolic disorder that has become a global health concern. The existing pharmaceutical drugs for treating obesity have some side effects. Compounds from natural sources are prospective substitutes for treating chronic diseases such as obesity, with the added advantages of being safe and cost‐effective. However, due to factors such as poor solubility, low bioavailability, and instability in the physiological environment, the therapeutic efficacy of phytoconstituents is limited. Nowadays, developing nanoscaled systems has emerged as a vital strategy for enhancing the delivery and therapeutic effect of phytoconstituents. The present study discusses and categorizes phytoconstituents with anti‐obesity effects and concludes the main mechanisms underlying their effects. Importantly, strategies used to develop phytoconstituent‐based nano‐drug delivery systems (NDDS) for obesity treatment that show improved efficacy relative to traditional administration routes are reviewed. Finally, the progress of research on phytoconstituent‐based NDDS for obesity treatment is summarized to provide a reference for the development of safe and effective treatment strategies for obesity.

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Celestrol-Loaded Nanoscale Micelles Derived from Dextran Sulfate/PVGLIG/Celestrol with MMP-2 Sensitivity for the Treatment of High-Fat-Diet-Induced Obesity

Cited by 7 publications

References 36 publications

Gold Nanobipyramid‐Mediated Apoptotic Camouflage of Adipocytes for Obesity Immunotherapy

Gold Nanobipyramid‐Mediated Apoptotic Camouflage of Adipocytes for Obesity Immunotherapy

Heavily Labeled Signal Probe for Electrogenerated Chemiluminescence Peptide‐Based Biosensing of Matrix Metalloproteinase 2

Recent Advances in the Anti‐Obesity Benefits of Phytoconstituents: From Phytochemistry to Targeting Novel‐Systems

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