Celiac disease and a novel association with a multifocal acquired motor axonopathy (MAMA)

Santos, Miguel Oliveira; Ohana, Benjamim; Carvalho, Mamede de

doi:10.1016/j.clinph.2017.06.038

Cited by 3 publications

(4 citation statements)

References 7 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…3 A single patient with multifocal acquired motor axonopathy found to have CD did not show clinical benefit with gluten-free diet despite normalization of antibodies. 4 The case reported here highlights the importance of testing for CD in patients with CIDP even without gastrointestinal symptoms and suggests that gluten-free diet along with immunotherapy may enable patients with CD-related CIDP to achieve sustained remission.…”

mentioning

confidence: 76%

“…Some evidence suggests that CD-associated neuropathic symptoms can improve with a gluten-free diet. [2][3][4] We present a 77-year-old man with a history of undifferentiated connective tissue disease/ clinical dermatomyositis in remission and 2 years of Parkinson disease, who was diagnosed with CIDP at age 69, was found to have CD and achieved sustained remission after intravenous immune globulin (IVIG) therapy and strict gluten-free diet.…”

mentioning

confidence: 99%

See 1 more Smart Citation

Sustained Remission of Chronic Inflammatory Demyelinating Polyradiculoneuropathy Associated With Celiac Disease After Immunotherapy and Gluten-Free Diet

Pullman

Lewis

Brannagan

et al. 2021

Journal of Clinical Neuromuscular Disease

View full text Add to dashboard Cite

mentioning

confidence: 76%

mentioning

confidence: 99%

Sustained Remission of Chronic Inflammatory Demyelinating Polyradiculoneuropathy Associated With Celiac Disease After Immunotherapy and Gluten-Free Diet

Pullman

Lewis

Brannagan

et al. 2021

Journal of Clinical Neuromuscular Disease

View full text Add to dashboard Cite

“…There are studies showing unchanged levels of antibodies to TSH type 6 and gliadin during a GFD [ 3 , 21 , 39 ]. However, the positive effects of intravenous Ig [ 24 ], as well as the presence of incomplete regression of the clinical manifestations of neuropathy following implementation of the diet [ 3 ], substantiate the use of membrane plasma exchange to accelerate and increase the effectiveness of therapy.…”

Section: Discussionmentioning

confidence: 99%

“…The spectrum of gluten neuropathy variants is highly diverse and includes: sensory and sensorimotor symmetric axonal polyneuropathies [ 23 ]; polyneuropathy of thin fibers [ 10 ]; multifocal acquired motor neuropathy [ 24 , 25 ]; sensory ganglionopathy (sensory neuronopathy) [ 26 ]; autonomic neuropathy (dysautonomia) manifested by postural nausea, syncope, tachycardia, and dizziness [ 27 ]; carpal tunnel syndrome [ 28 ]; and asymmetric sensory polyneuropathy [ 10 ]. Cases of acute axonal demyelinating forms in childhood have also been described [ 29 ].…”

Section: Introductionmentioning

confidence: 99%

Acrodystrophic axonal polyneuropathy with celiac disease: a case report

et al. 2021

View full text Add to dashboard Cite

Background Patients with celiac disease present with not only gastrointestinal symptoms but also extraintestinal manifestations such as anemia, osteopathy, dermatitis herpetiformis, and celiac neuropathy. Despite a fairly wide range of celiac neuropathies, we report a case of the acrodystrophic variant of celiac polyneuropathy, which has not been previously described. Case presentation A 41-year-old Ukrainian male suffered from symmetric, sensorimotor axonal polyneuropathy and encephalopathy associated with celiac disease, which is characterized by severe trophic disorders in the lower extremities (trophic ulcers, hyperkeratosis, and anhidrosis). Acrodystrophic changes in the lower extremities were due to both neurogenic and direct immunoinflammatory damaging effects. Clinical–electrophysiological dissociation was also noted, which was represented by a gross axonal lesion with the preservation of muscle strength. The absence of enteropathic manifestations was accompanied by the pronounced histological changes in the duodenal mucosa by IIIb stage of Marsh. A gluten-free diet in combination with membrane plasma exchange and intravenous pulse methylprednisolone was prescribed to reduce the severity of sensory disorders and regression of encephalopathy within 7 months. Conclusion Celiac disease may be a potential cause of neuropathy and encephalopathy in adult patients. Further immunosuppressive treatment protocols for both intestinal and extraintestinal manifestations of celiac disease are required.

show abstract

Neurological syndromes of celiac disease

Kopishinskaia

Никитин²

2021

Medicinskij alfavit

View full text Add to dashboard Cite

Celiac disease is an autoimmune disease in people with a genetic predisposition resulting from the consumption of gluten proteins from wheat, rye, barley and characterized by inflammation of the mucous membrane of the small intestine and atrophy of the villi. Neuropathy, migraine, chronic cerebellar ataxia and fibromyalgia are the most common extraintestinal celiac disease syndromes. The study of small nerve fibers is necessary for painful celiac disease syndromes such as gluten neuropathy and fibromyalgia, as well as for gluten autonomic neuropathy. The study of antineuronal antiganglioside antibodies is necessary for such lesions of both the central and peripheral nervous systems as gluten neuropathy and gluten cerebellar ataxia. A gluten-free diet directly affects the disappearance of headache attacks or a decrease in their frequency and intensity. There is little research on the effect of a gluten-free diet on headache risk.

show abstract

Celiac disease and a novel association with a multifocal acquired motor axonopathy (MAMA)

Cited by 3 publications

References 7 publications

Sustained Remission of Chronic Inflammatory Demyelinating Polyradiculoneuropathy Associated With Celiac Disease After Immunotherapy and Gluten-Free Diet

Sustained Remission of Chronic Inflammatory Demyelinating Polyradiculoneuropathy Associated With Celiac Disease After Immunotherapy and Gluten-Free Diet

Acrodystrophic axonal polyneuropathy with celiac disease: a case report

Neurological syndromes of celiac disease

Contact Info

Product

Resources

About