Celiac disease and alcohol use disorders: increased length of hospital stay, overexpenditures and attributable mortality

Abstract

Background and objectives: alcohol use disorders are associated with a greater incidence of certain comorbidities in patients with celiac disease. Currently there is no available information about the impact that these disorders may have on length of hospital stays, overexpenditures during hospital stays, and excess mortality in these patients.Methods: a case-control study was conducted with a selection of patients 18 years and older hospitalized during 2008-2010 in 87 hospitals in Spain. Estimations of excess length of stays, costs, and attributable mortality were calculated using a multivariate analysis of covariance, which included age, gender, hospital group, alcohol use disorders, tobacco related disease and 30 other comorbidities.Results: patients who had both celiac disease and alcohol use disorders had an increased length of hospital stay, an average of 3.1 days longer in women, and 1.7 days longer in men. Excess costs per stay ranged from 838.7 euros in female patients, to 389.1 euros in male patients. Excess attributable mortality was 15.1 % in women, 12.2 % in men.Conclusions: apart from a gluten-free diet and other medical measures, the prevention of alcohol abuse is indicated in these patients. Patients hospitalized who present these disorders should receive specialized attention after leaving the hospital. Early detection and treatment should be used to prevent the appearance of organic lesions and should not be solely focused on male patients.

Psychiatric Comorbidity in Children and Adults with Gluten-Related Disorders: A Narrative Review

“…Studies were published between 1982 and 2018 [ 45 , 46 , 47 , 48 , 49 , 50 , 51 , 52 , 53 , 54 , 55 , 56 , 57 , 58 , 59 , 60 , 61 , 62 , 63 , 64 , 65 , 66 , 67 , 68 , 69 , 70 , 71 , 72 , 73 , 74 , 75 , 76 ]. More than half of these studies were of cross-sectional design [ 45 , 48 , 51 , 53 , 54 , 55 , 56 , 57 , 59 , 60 , 63 , 67 , 68 , 71 , 72 , 74 , 75 , 76 ] and four of them were representative of the general population [ 47 , 70 ,…”

“…While patients with CD were less likely to experience alcohol-related disorders [ 72 ], their risk of developing dementia was significantly higher as shown in a population-based cohort study [ 70 , 73 ]. The likelihood of developing poor sleep in CD based on the use of hypnotics was significantly elevated compared to controls HR = 1.36, 95% CI: 1.3–1.41) in the population-based case-control study conducted by Marild et al [ 70 ].…”