Celiac disease and alopecia areata: Report of a new association

Corazza, Gino Roberto; Andreani, Mariarita; Venturo, Nicola; Bernardi, Mauro; Tosti, Antonella; Gasbarrini, Giovanni

doi:10.1016/0016-5085(95)90597-9

Cited by 116 publications

(74 citation statements)

References 28 publications

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“…In fact, certain subjects with autoimmune diseases who were diagnosed with coeliac disease by screening showed a relative improvement in the associated disease when placed on a gluten-free diet [22,31,32]. No similar phenomenon was observed in our patients with Type I diabetes, autoimmune thyroiditis or multiple sclerosis, probably because of differences in the reparative capacity and functioning of human tissue and also in the duration of the gluten-dependent immune aggression.…”

Section: Discussionmentioning

confidence: 51%

Undiagnosed coeliac disease and risk of autoimmune disorders in subjects with Type I diabetes mellitus

et al. 2001

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AIMS/HYPOTHESIS: We tested the hypothesis that silent coeliac disease is more frequent than expected in both patients with Type I (insulin-dependent) diabetes mellitus and their first-degree relatives. We evaluated how the presence of other autoimmune disorders in diabetic patients and their first-degree relatives is related to silent, unrecognized coeliac disease. METHODS: Sera from 491 subjects with Type I diabetes, 824 relatives and 4,000 healthy control subjects were screened for anti-endomysial antibodies and all those subjects who tested positive for anti-endomysial antibodies underwent intestinal biopsy. RESULTS: We found that the prevalence of coeliac disease was 5.7 \% among the diabetic patients and 1.9 \% among the relatives, values significantly higher than those found among the control subjects (p < 0.0001; p < 0.001). The prevalence of autoimmune disorders in diabetic patients with coeliac disease was significantly higher than in subjects with Type I diabetes alone (p < 0.0001). The prevalence of autoimmune disorders in the relatives with coeliac disease was significantly higher than in those who tested negative for anti-endomysial antibodies (p = 0.01). CONCLUSION/INTERPRETATION: This report provides further confirmation of the high prevalence of undiagnosed coeliac disease among diabetic patients and their relatives. This interesting new finding is the increased presence of other autoimmune diseases in these patients, as well as in their relatives with a delayed diagnosis for coeliac disease. Patients newly diagnosed with coeliac disease showed excellent compliance with the gluten-free diet. This should encourage policymakers to consider introducing an easy-to-use screening programme for diabetic patients and their relatives into everyday clinical practice, in order to prevent coeliac-associated symptoms and the onset of additional, more serious auto-immune disorders

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Section: Discussionmentioning

confidence: 51%

Undiagnosed coeliac disease and risk of autoimmune disorders in subjects with Type I diabetes mellitus

et al. 2001

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“…In the literature an association between AA and CD has been reported and considered not casual on the basis of prevalence data [5, 6]. In these series CD was found in 8 patients out of 488 alopecic patients.…”

Section: Discussionmentioning

confidence: 89%

“…Recently, an association between AA and coeliac disease (CD) has been reported in two different series of about 250 patients each. Five cases were detected in these series, while 7 other patients with the same association have been described as case reports [5, 6, 7, 8]. In 6 of these patients, a gluten-free diet (GFD) was followed by a partial or complete regrowth of hair [5, 6, 7].…”

Section: Introductionmentioning

confidence: 95%

Alopecia areata and Coeliac Disease: No Effect of a Gluten-Free Diet on Hair Growth

Bardella¹,

Marino²,

Barbareschi

et al. 2000

Dermatology

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Background: An association between alopecia areata (AA) and coeliac disease has recently been reported. Aim: The aim of this paper was to evaluate the possible effect of a gluten-free diet (GFD) on the new growth of hair in 5 alopecic patients with CD. Methods: CD was diagnosed in 5 patients with AA (universalis in 3 cases and patchy in 2 cases). The diagnosis of CD was based on serological and histological standard criteria. Results: In all patients the GFD resolved CD clinically, serologically and histologically but had no effect on the course of alopecia. Conclusion: AA and CD, when associated, present different responses to a GFD and have an independent course.

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“…Another feature of coeliac disease is its close association with other autoimmune disorders, especially type-I diabetes, autoimmune thyroid diseases, collagen disorders, Addison’s disease, pernicious anaemia, alopecia and autoimmune hepatitis [2, 3, 4, 5, 6, 7]. Several studies have investigated the correlation between coeliac disease and autoimmune thyroid dysfunction.…”

Section: Introductionmentioning

confidence: 99%

Coeliac Disease in Patients with Autoimmune Thyroiditis

et al. 2001

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Background and Aims: The close association between coeliac disease and autoimmunity prompted us to perform an antibody screening for gluten-sensitive enteropathy in patients with autoimmune thyroid dysfunction. Methods: Sera from 220 patients with autoimmune thyroiditis, 50 euthyroid subjects with thyroid nodules and 250 blood donors were tested for IgA anti-tissue transglutaminase (anti-tTG) and antiendomysial antibodies (EmA). Results: IgA anti-tTG was positive in 7 patients with autoimmune thyroiditis, whereas IgA EmA was found only in 6 of them. Duodenal biopsy confirmed coeliac disease diagnosis disclosing marked and mild villous atrophy in 6 and 1 of them, respectively. All but 2 of the 7 coeliacs did not show any sign of malabsorption. All euthyroid controls were negative for IgA antibodies, whereas 1 blood donor, positive for both IgA anti-tTG and EmA, was found to be coeliac. The prevalence of coeliac disease in patients with autoimmune thyroiditis (3.2%) was significantly higher than that found in blood donors (0.4%) (p = 0.022, Fisher’s exact test). Conclusions: Antibody screening for coeliac disease should be included in the work-up of patients with autoimmune thyroiditis. Either IgA anti-tTG or EmA may be used, even though the former seems to be slightly more sensitive than the latter.

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Celiac disease and alopecia areata: Report of a new association

Cited by 116 publications

References 28 publications

Undiagnosed coeliac disease and risk of autoimmune disorders in subjects with Type I diabetes mellitus

Undiagnosed coeliac disease and risk of autoimmune disorders in subjects with Type I diabetes mellitus

Alopecia areata and Coeliac Disease: No Effect of a Gluten-Free Diet on Hair Growth

Coeliac Disease in Patients with Autoimmune Thyroiditis

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