Celiac disease and HLA-DQ genotype: diagnosis of different genetic risk profiles related to the age in Badajoz, southwestern Spain

Abstract

Background and objectives: celiac disease is associated with the HLA class II alleles: DQA1*05-DQB1*02 and DQB1*0302.

Mapping of HLA– DQ haplotypes in a group of Danish patients with celiac disease

“…For example, the differences in frequency of HLa DQ2.5 and HLa DQ8 between children and adults with CD (Table ii) were also found in a spanish CD population [14].…”

Histopathological findings in the oral mucosa of celiac patients

“…CD is strictly linked to a genetic predisposition given by particular human leukocyte antigens (HLA), in particular HLA-DQB1 (DQ2 antigen or DQ8 antigen) (6)(7)(8)(9)(10). Further, for the realization of the immune reaction responsible for the disease, it is necessary that the gliadin exceeds the intestinal epithelium and reaches the lamina propria, at the level of which interacts with the tissue transglutaminase giving a reaction of Th1 type, with production of specific cytokines and consequent tissue damage, which is manifested by the histological lesions of the duodenal mucosa, and a reaction of Th2 type, in which there is the activation of B lymphocytes into plasma cells and production of antibodies of the type IgA directed against the gliadin, the endomysium and tissue transglutaminase (6,(11)(12).…”

Intestinal Microbiota and Probiotics in Celiac Disease

“…It is associated mostly with the human leukocyte antigen (HLA-DQ) system, which participates in the recognition of self and nonself molecules by the immune system. The variants HLA-DQ2 and/or -DQ8 as well as HLA-DP and HLA-DR are commonly observed in CD patients (6,7). These gene variants produce receptors that bind to gliadin peptides more tightly than other forms of the antigen-presenting receptor.…”