Celiac Disease and Turner Syndrome

Bonamico, Margherita; Bottaro, G; Pasquino, Anna Maria; Caruso-Nicoletti, Manuela; Mariani, P; Gemme, G; Paradiso, E.; Ragusa, Maria Carlotta; Spina, Massimo

doi:10.1097/00005176-199805000-00002

Cited by 61 publications

(27 citation statements)

References 29 publications

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“…The prevalence of celiac disease in patients with Turner's syndrome also appears to be higher than in the general population, with a range of 2%-10% and a pooled estimate of 6.3% (95% CI, 4.57%-8.64%). [212][213][214][215][216] As in Down syndrome, patients with celiac disease with Turner's syndrome are DQ2 positive, but the prevalence of DQ2 in patients with Turner's syndrome may not be higher than in the general population. 216 The prevalence of celiac disease may also be increased in patients with Williams syndrome, although limited data are available.…”

Section: Prevalence Of Celiac Disease In Patients With Other Disordersmentioning

confidence: 99%

American Gastroenterological Association (AGA) Institute Technical Review on the Diagnosis and Management of Celiac Disease

2006

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Section: Prevalence Of Celiac Disease In Patients With Other Disordersmentioning

confidence: 99%

American Gastroenterological Association (AGA) Institute Technical Review on the Diagnosis and Management of Celiac Disease

2006

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“…This lends weight to the theory that the cause of IBD may be immune dysfunction. The reports of an increased prevalence of coeliac disease in TS [93]have thus far been unsubstantiated.…”

Section: Clinical Manifestations Of Turner Syndrome In Adultsmentioning

confidence: 99%

Adulthood in Women with Turner Syndrome

Ostberg

Conway²

2003

Horm Res Paediatr

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Turner syndrome, resulting from a complete or partial absence of one X chromosome, is the most commonly occurring chromosomal abnormality in females. Patients have traditionally been carefully followed in paediatric practice during childhood, but were often discharged to primary care on reaching adulthood. Adults with Turner syndrome are thought to have a reduced life expectancy, mainly due to excess cardiovascular risk, but they may also have multiple comorbidities including hypothyroidism, deafness, osteoporosis and the attendant problems of oestrogen deficiency and infertility. A multidisciplinary approach to focused adult care is needed, with consideration of how to optimise surveillance strategies in these women.

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“…Furthermore, some studies have reported an increased prevalence of CD among patients with Turner’s syndrome [14, 15], and the management of hypogonadism and delayed puberty may be even more complex in untreated CD Turner’s patients. However, more studies are necessary to evaluate correlations between CD and Turner’s syndrome.…”

Section: Pubertymentioning

confidence: 99%

Mechanisms of Abnormal Puberty in Coeliac Disease

Bona

Marinello

Oderda³

2002

Horm Res Paediatr

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Coeliac disease (CD) is one of the most frequent chronic diseases in childhood. The clinical spectrum has changed; in addition to the classical gastrointestinal form, other clinical manifestations have been described, such as hypogonadism and the consequent delay in onset of puberty. Recent studies reported not only a significantly retarded menarche in untreated CD girls as compared with girls following a gluten-free diet, but also in treated CD a negative effect on pregnancy, resulting in lower birth weight and shorter duration of pregnancy. In boys, there is a reduced serum level of dihydrotestosterone and an increased serum level of luteinizing hormone, an abnormality pattern suggesting androgen resistance. The pathogenesis of CD-related reproductive disorders is still unclear. Some hypotheses may be tried; for example, in CD there is a high level of autoantibodies directed against self-antigens, so there could be antibodies directed against hormones or organs critical for pubertal development. Moreover, in CD there could be a selective malabsorption of micronutrients essential for the metabolism of carrier or receptor proteins for sex hormones.

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Celiac Disease and Turner Syndrome

Cited by 61 publications

References 29 publications

American Gastroenterological Association (AGA) Institute Technical Review on the Diagnosis and Management of Celiac Disease

American Gastroenterological Association (AGA) Institute Technical Review on the Diagnosis and Management of Celiac Disease

Adulthood in Women with Turner Syndrome

Mechanisms of Abnormal Puberty in Coeliac Disease

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