Celiac disease: clinical characteristics and methods used in the diagnosis of patients registered at the Brazilian Celiac Association

Sdepanian, Vera Lúcia; Morais, Mauro Batista de; Fagundes-Neto, Ulysses

doi:10.2223/jped.189

Cited by 5 publications

(4 citation statements)

References 27 publications

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“…In addition, in a previous Brazilian study, 97.6% of celiac patients participants were white (29) , which is in agreement with what was observed in our study (92.8%). Additionally, the main symptoms displayed by celiac patients of this study before treatment was similar to those presented by celiac residents in another region of Brazil (27) and those described in reviews in the literature (7,15,17,22) .…”

Section: Discussionsupporting

confidence: 93%

Lower Bifidobacteria Counts in Adult Patients With Celiac Disease on a Gluten-Free Diet

Golfetto

Senna

Hermes

et al. 2014

Arq. Gastroenterol.

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-Context -The ingestion of gluten is responsible for the symptoms of Celiac disease, but other environmental factors can also influence. Strains of the Bifidobacterium genus have been shown to afford protection against the inflammatory response and mucosal damage caused by gliadin peptides in vitro. Objective -This study was designed to compare the concentration of fecal bifidobacteria and pH of patients with celiac disease on gluten-free diet and control subjects in order to identify if the imbalance on fecal microbiota still remain during the treatment of celiac disease and identify the necessity of dietary supplementation with pre-or probiotics. Methods -It was analyzed the feces of 42 healthy subjects and 14 celiac patients. The bifidobacteria count in feces was done in selective medium BIM-25. Microscopic analysis of the colonies was performed by Gram stain. The identification of the genus Bifidobacterium was performed by determination of fructose-6-phosphate phosphoketolase. Fecal pH was measured using a pH meter. Results -The concentration of bifidobacteria per gram of feces was significantly higher in healthy subjects (controls) (1.5 ± 0.63 x10 8 CFU/g) when compared to celiac patients (2.5 ± 1.5 x10 7 CFU/g). The fecal pH was not different between celiac patients (7.19 ± 0.521) and controls (7.18 ± 0.522). Conclusion -These results suggest that with lower levels of bifidobacteria, celiac patients have an imbalance in the intestinal microbiota, regardless of pH, even while on a gluten-free diet. This fact could favor the pathological process of the disorder. HEADINGS -Bifidobacterium. Microbiota. Hydrogen-Ion concentration. Celiac disease. Gluten-free diet.Declared conflict of interest of all authors: none Source of Funding: no funding has been received for the research.

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Section: Discussionsupporting

confidence: 93%

Lower Bifidobacteria Counts in Adult Patients With Celiac Disease on a Gluten-Free Diet

Golfetto

Senna

Hermes

et al. 2014

Arq. Gastroenterol.

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“…Celiac disease (CD) is a permanent intolerance to gluten that occurs in genetically susceptible individuals and is characterized by complete or partial atrophy of the mucosa of the proximal small bowel, hyperplasia of the intestinal crypts and intraepithelial lymphocytic infiltration, leading to malabsorption of dietary nutrients (1) . CD is considered a chronic immune-mediated enteropathy (2) and is closely associated with the major histocompatibility complex (MHC) class II molecules HLA-DQ2 and HLA-DQ8 (3) .…”

Section: Introductionmentioning

confidence: 99%

Doença celíaca e constipação: uma manifestação clínica atípica e pouco frequente

Boé

Lozinsky

Patrı́cio

et al. 2012

Rev. paul. pediatr.

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OBJETIVO: Relatar dois casos de doença celíaca (DC) com manifestação de constipação. DESCRIÇÃO DO CASO: Dois pacientes do sexo feminino, com 18 e 30 meses de idade, respectivamente, apresentando história de constipação crônica refratária ao tratamento. Como apresentavam concomitantemente baixo ganho ponderal e estatural, foi realizada investigação da função digestiva-absortiva, que resultou positiva para o anticorpo IgA antitransglutaminase tecidual. O diagnóstico de DC foi confirmado por biópsia de intestino delgado que revelou atrofia vilositária moderada/intensa e infiltrado linfocítico intraepitelial. Um mês após o início do tratamento com dieta isenta de glúten, ambas as pacientes passaram a apresentar fezes pastosas diariamente. COMENTÁRIOS: A DC pode se apresentar nas formas clássica, assintomática e atípica, em que manifestações isoladas como constipação podem retardar o diagnóstico.

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“…No Brasil, ainda é grande o número de pacientes com diagnóstico de DC não confirmado por biópsia, repercutindo negativamente na adesão ao tratamento (Sdepanian et al, 2001). Contribuem para este quadro, a baixa disponibilidade dos testes sorológicos na maioria das cidades brasileiras e a dificuldade de acesso da população à biópsia intestinal (Gandolfi et al, 2000).…”

Section: 23-critérios Diagnósticosunclassified

“…Contribuem para este quadro, a baixa disponibilidade dos testes sorológicos na maioria das cidades brasileiras e a dificuldade de acesso da população à biópsia intestinal (Gandolfi et al, 2000). (Sdepanian et al, 2001). Este fato tem sido descrito por outros autores, principalmente em países em que a realização de triagens sorológicas já é realidade (Schober et al, 2002).…”

Section: 23-critérios Diagnósticosunclassified

Prevalencia e aspectos clinicos da associação entre diabetes mellitus tipo 1 e doença celiaca

Whitacker¹

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Justify: There were four decades that the association between Diabetes Mellitus type 1 (DM1) and celiac disease is known. However, the manifestation of celiac disease in diabetic patients is predominantly atypical, what difficult its diagnosis and the recognition of possible effect of this association in the control of diabetes. Objectives: To estimate the prevalence of DM1 and celiac disease association and to verify the existence of celiac disease symptoms, the occurrence of other autoimmune diseases among the patients and their first-degree relatives and the possible influences of celiac disease in diabetes control.Patients and methods: It was done a cross-sectional study with 195 patients that ansewered a questionnaire about gastrintestinal symptoms and the occurrence of autoimmune diseases in theirs first-degree relatives. IgA was measured and antiendomysial antibody (EMA) screened. The patients with positive EMA were submitted to intestinal biopsy. Those with celiac disease confirmed by biopsy (case group) were paired with DM1 patients without celiac disease (control group) according to age at the screening, time of diabetes duration and gender. Results: EMA was positive in nine patients. In seven of them the biopsy confirmed celiac disease (4.0%). Comparing the cases with controls, the gastrointestinal symptoms were significantly more frequent in the first group and there was no difference between the groups regarding to the control of diabetes. Conclusions: The prevalence found was 4.0%. This sample of celiac patients showed a predominance of gastrointestinal symptoms and the celiac disease did not influence the diabetes control.

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Celiac disease: clinical characteristics and methods used in the diagnosis of patients registered at the Brazilian Celiac Association

Cited by 5 publications

References 27 publications

Lower Bifidobacteria Counts in Adult Patients With Celiac Disease on a Gluten-Free Diet

Lower Bifidobacteria Counts in Adult Patients With Celiac Disease on a Gluten-Free Diet

Doença celíaca e constipação: uma manifestação clínica atípica e pouco frequente

Prevalencia e aspectos clinicos da associação entre diabetes mellitus tipo 1 e doença celiaca

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