Celiac Disease: Evaluation with Dynamic Contrast-enhanced MR Imaging

Masselli, Gabriele; Picarelli, Antonio; Tola, Marco Di; Libanori, Valerio; Donato, Giuseppe; Polettini, E; Piermattei, Alessandra; Palumbo, Piergaspare; Pittalis, Angelo; Saponara, Annarita; Gualdi, Gianfranco

doi:10.1148/radiol.10092160

Cited by 35 publications

(20 citation statements)

References 25 publications

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“…Because dynamic contrast-enhanced MR imaging parameters have been found to differ substantially between patients with untreated versus those with treated celiac disease, these sequences may help to identify and evaluate bowel wall inflammation in such patients (68). Gadolinium should not be used in patients with impaired are needed to define the practical clinical value of diffusion-weighted imaging.…”

Section: Review: Mr Imaging Of the Small Bowelmentioning

confidence: 99%

MR Imaging of the Small Bowel

Masselli¹,

Gualdi²

2012

Radiology

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170

118

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Section: Review: Mr Imaging Of the Small Bowelmentioning

confidence: 99%

MR Imaging of the Small Bowel

Masselli¹,

Gualdi²

2012

Radiology

Self Cite

170

118

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“…It is defined as a bowel wall thickness measuring more than 3 mm in a distended loop and may be eccentric or concentric and smooth or nodular and several study [5,43] . Masselli et al [42] confirmed that the terminal ileum is the most common localiazation of bowel wall thickness ( Figure 2). Stratified contrast enhancement with avid enhancement of the mucosa relative to the submucosa and muscular layers helps to confirm active CD [51] ( Figure 1C).…”

Section: Indicationsmentioning

confidence: 87%

Current tecniques and new perpectives research of magnetic resonance enterography in pediatric Crohn’s disease

Masselli

Mastroiacovo

Marco

et al. 2016

WJR

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Crohn's disease affects more than 500000 individuals in the United States, and about 25% of cases are diagnosed during the pediatric period. Imaging of the bowel has undergone dramatic changes in the past two decades. The endoscopy with biopsy is generally considered the diagnostic reference standard, this combination can evaluates only the mucosa, not inflammation or fibrosis in the mucosa. Actually, the only modalities that can visualize submucosal tissues throughout the small bowel are the computed tomography (CT) enterography (CTE) with the magnetic resonance enterography (MRE). CT generally is highly utilized, but there is growing concern over ionizing radiation and cancer risk; it is a very important aspect to keep in consideration in pediatric patients. In contrast to CTE, MRE does not subject patients to ionizing radiation and can be used to detect detailed morphologic information and functional data of bowel disease, to monitor the effects of medical therapy more accurately, to detect residual active disease even in patients showing apparent clinical resolution and to guide treatment more accurately.

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“…The proximal edge of the pancreatic tumor tissue was 5 mm deep from the inner duodenal wall, and the overall dimensions of the tissue block were 50 × 50 × 73.5 mm. The duodenal luminal wall was modeled as distended with a 2 mm thickness [53]. Tissue thermal domains closer to the transducer were meshed at a finer resolution (equivalent to the acoustic wavelength) to appropriately capture the steep heating gradients near the applicator.…”

Section: Methodsmentioning

confidence: 99%

“…Localized cooling effects of major blood vessels were modeled using heat flux boundary conditions at the inner surface of the blood vessels, with an ambient blood temperature of 37 °C, and the heat transfer coefficient h value was calculated using the method detailed by Haemmerich et al, with vasculature parameters obtained from literature [55–60]. The duodenal and stomach walls were modeled as 2 mm and 3 mm thick, respectively [53,61,62]. Feedback control over the maximum tumor temperature was applied for the ablation simulations and transient temperature solutions were obtained.…”

Section: Methodsmentioning

confidence: 99%

Thermal therapy of pancreatic tumours using endoluminal ultrasound: Parametric and patient-specific modelling

Adams

Scott

Salgaonkar

et al. 2016

International Journal of Hyperthermia

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Purpose To investigate endoluminal ultrasound applicator configurations for volumetric thermal ablation and hyperthermia of pancreatic tumors using 3D acoustic and biothermal finite element models. Materials and Methods Parametric studies compared endoluminal heating performance for varying applicator transducer configurations (planar, curvilinear-focused, or radial-diverging), frequencies (1–5 MHz), and anatomical conditions. Patient-specific pancreatic head and body tumor models were used to evaluate feasibility of generating hyperthermia and thermal ablation using an applicator positioned in the duodenal or stomach lumen. Temperature and thermal dose were calculated to define ablation (>240 EM43°C) and moderate hyperthermia (40–45 °C) boundaries, and to assess sparing of sensitive tissues. Proportional-integral control was incorporated to regulate maximum temperature to 70–80 °C for ablation and 45 °C for hyperthermia in target regions. Results Parametric studies indicated that 1–3 MHz planar transducers are most suitable for volumetric ablation, producing 5–8 cm3 lesion volumes for a stationary 5 minute sonication. Curvilinear-focused geometries produce more localized ablation to 20–45 mm depth from the GI tract and enhance thermal sparing (Tmax<42 °C) of the luminal wall. Patient anatomy simulations show feasibility in ablating 60.1–92.9% of head/body tumor volumes (4.3–37.2 cm3) with dose <15 EM43°C in the luminal wall for 18–48 min treatment durations, using 1–3 applicator placements in GI lumen. For hyperthermia, planar and radial-diverging transducers could maintain up to 8 cm3 and 15 cm3 of tissue, respectively, between 40–45 °C for a single applicator placement. Conclusions Modeling studies indicate the feasibility of endoluminal ultrasound for volumetric thermal ablation or hyperthermia treatment of pancreatic tumor tissue.

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Celiac Disease: Evaluation with Dynamic Contrast-enhanced MR Imaging

Abstract: The results of this study suggest that dynamic evaluation of the bowel wall by using contrast-enhanced MR imaging can be an effective and reproducible way to show the inflammation state in celiac disease.

Cited by 35 publications

References 25 publications

MR Imaging of the Small Bowel

MR Imaging of the Small Bowel

Current tecniques and new perpectives research of magnetic resonance enterography in pediatric Crohn’s disease

Thermal therapy of pancreatic tumours using endoluminal ultrasound: Parametric and patient-specific modelling

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