Celiac disease: From gluten to autoimmunity

Briani, Chiara; Samaroo, Diana; Alaedini, Armin

doi:10.1016/j.autrev.2008.05.006

Cited by 165 publications

(132 citation statements)

References 39 publications

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“…These reactions are not restricted to celiac disease, but also include nonceliac gluten sensitivity and wheat allergy, which combined affect about 10% of the general population (Battais et al, 2003(Battais et al, , 2005Lammers et al, 2014;Williams et al, 2010;Woodward, 2010). Moreover, they represent distinct pathophysiological reactions to gluten ingestion, with differing clinical presentations, serological markers, and long-term treatments (Bai et al, 2013;Briani et al, 2008;Ciclitira et al, 2005b). Although current research attempts to elucidate the frontiers between these reactions, their differences can be difficult to discriminate.…”

Section: Gliadins and The Celiac Diseasementioning

confidence: 99%

Gliadins in Foods and the Electronic Tongue

Veloso

Dias

Rodrigues

et al. 2016

Electronic Noses and Tongues in Food Science

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Section: Gliadins and The Celiac Diseasementioning

confidence: 99%

Gliadins in Foods and the Electronic Tongue

Veloso

Dias

Rodrigues

et al. 2016

Electronic Noses and Tongues in Food Science

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“…IELs are involved in the primary response to foreign antigens (e.g., food and microbial proteins), but are also autoreactive to "self-engendered" molecules deriving from infection or cell transformation; these molecules are independent of foreign epitopes [27]. The adaptive immune response taking place in the lamina propria, which has been well characterized in celiac disease with CD4+ T cells responding to antigens in a MHC class II restricted manner [28][29][30][31], is also implicated in IBDs. Innate and adaptive immune response are mediated by dendritic cells in the intestinal mucosa which, through the release of different cytokines, may either induce tolerance or evoke a cascade of inflammatory events ultimately leading to chronic inflammation.…”

Section: Inflammatory Bowel Diseases (Ibds) -Epidemiology Genetics Amentioning

confidence: 99%

Inflammatory bowel diseases: from pathogenesis to laboratory testing

Basso

Zambon²,

Plebani³

2014

Clinical Chemistry and Laboratory Medicine

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Inflammatory bowel diseases (IBDs), which comprise the two major clinical subtypes, Crohn's disease and ulcerative colitis, incur high morbidity and potential mortality. The present study reviews data on the pathogenesis and diagnosis of IBDs. The pathogenesis depends on complex interactions between susceptibility genes, environmental factors, and innate and adaptive immunity, the understanding of which is crucial to discovering novel laboratory biomarkers. Traditional laboratory tests for the diagnosis, prognosis and assessment of disease activity of IBDs are reported on, and the biochemical properties, preanalytical and analytical aspects and clinical utility of the fecal markers lactoferrin and calprotectin are described. DNA testing and established (ASCA and pANCA) and emerging (ACCA, ALCA, AMCA, OmpC) serum markers are described; a further aspect to be addressed is the clinical use of pharmacogenetics for the treatment of IBDs.

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“…A biopsy might also be recommended in cases of negative serology, when there is a high clinical suspicion. In positive serological cases, followed by a negative biopsy, it is important to consider HLA typing, since the absence of both HLA-DQ2 and/or HLA-DQ8 alleles has a very high negative predictive value, helping to rule out the disease in cases of equivocal biopsy results [3,4,56].…”

Section: Biological Markersmentioning

confidence: 99%

“…observed that the ingestion of certain cereal grains was harmful to children with celiac disease [2,3]; later, John W Pauley described the associated histologic changes in the intestine [4].…”

Section: Introductionmentioning

confidence: 99%

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Celiac disease diagnosis and gluten-free food analytical control

et al. 2010

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Celiac disease (CD) is an autoimmune entero-pathy, characterized by an inappropriate T-cell-mediated immune response to the ingestion of certain dietary cereal proteins in genetically susceptible individuals. This disorder presents environmental, genetic, and immunological com-ponents. CD presents a prevalence of up to 1% in populations of European ancestry, yet a high percentage of cases remain underdiagnosed. The diagnosis and treatment should be made early since untreated disease causes growth retardation and atypical symptoms, like infertility or neurological disorders. The diagnostic criteria for CD, which requires endoscopy with small bowel biopsy, have been changing over the last few decades, especially due to the advent of serological tests with higher sensitivity and specificity. The use of serological markers can be very useful to rule out clinical suspicious cases and also to help monitor the patients, after adherence to a gluten-free diet. Since the current treatment consists of a life-long gluten-free diet, which leads to significant clinical and histological improvement, the standardization of an assay to assess in an unequivocal way gluten in gluten-free foodstuff is of major importance.

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Celiac disease: From gluten to autoimmunity

Cited by 165 publications

References 39 publications

Gliadins in Foods and the Electronic Tongue

Gliadins in Foods and the Electronic Tongue

Inflammatory bowel diseases: from pathogenesis to laboratory testing

Celiac disease diagnosis and gluten-free food analytical control

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