Celiac disease in non-clinical populations of Japan

Fukunaga, Mai; Ishimura, Norihisa; Fukuyama, Chika; Izumi, Daisuke; Ishikawa, Nahoko; Araki, Asuka; Oka, Akihiko; Mishiro, Tsuyoshi; Ishihara, Shunji; Maruyama, Riruke; Adachi, Kyoichi; Kinoshita, Yoshikazu

doi:10.1007/s00535-017-1339-9

Cited by 53 publications

(32 citation statements)

References 38 publications

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“…Despite these notions, using HLA - DQ2/DQ8 typing as a routine screening test is hindered owing to their high penetrance in general population, which limits their positive predictive values (38). Furthermore, applicability of this approach for screening CD in populations with low penetrance of these alleles is not recommended as results in high rate of undiagnosed cases (39). …”

Section: Resultsmentioning

confidence: 99%

An Overview of Celiac Disease in Childhood Type 1 Diabetes

Shahramian

Bazi

Sargazi

2018

Int J Endocrinol Metab

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ContextCeliac disease (CD) is a common phenomenon in children with Type 1 diabetes (T1D). In the present review, we have discussed the pathogenesis, diagnostic biomarkers, risk factors, and prognosis of CD in the context of pediatric T1D.Evidence AcquisitionLiterature published in Web of Science, PubMed, Scopus, Google Scholar, and Cochrane Library were scrutinized up to the end of 2017. The keywords of celiac disease, Type 1 diabetes, children, and pediatric were used in different combinations.ResultsImmune cytotoxic reactions along with dampen immune regulatory functions contribute to CD in the context of pediatric T1D. Many children with simultaneous CD and T1D do not represent with the clinical signs of the enteropathy rendering a diagnostic challenge. The most common screening tests in these children are routine serological tests of CD, anti - endomysial, anti - transglutaminase, and anti - deamidated gliadin peptide antibodies. Typing for human leukocyte antigens of DQ - 2 and DQ - 8 may assist in the diagnosis of silent CD in children with T1D. The most significant shared non - HLA genetic loci of CD and T1D comprise CTLA - 4, TAGAP, IL - 18RAP, PTPN2, RGS1, SH2B3, CCR5. Interactions between these loci can be important in susceptibility to CD in T1D. Some new biomarkers have been suggested for diagnosis of CD including ischemia-modified albumin (IMA), soluble syndecan-1 (SSDC-1), regenerating gene Iα (REG-Iα), Neurotensin, and Zonulin, which can be useful for diagnosis and screening of CD in childhood T1D.ConclusionsOverall, active seropositive CD seems to be of clinical importance in T1D with significant impacts on the quality of life and predisposition to diabetes associated complications. It is important to detect CD in the context of T1D to prevent potential risks contributing to morbidities and mortalities associated with either CD or T1D.

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Section: Resultsmentioning

confidence: 99%

An Overview of Celiac Disease in Childhood Type 1 Diabetes

Shahramian

Bazi

Sargazi

2018

Int J Endocrinol Metab

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“…17 In a study from Malaysia, the seroprevalence of CeD was found to be 1.25% (95% CI, 0.78-1.72%) in a relatively small study including 562 young healthy volunteers. 18,19 Although there are suggestions of existence of CeD in Southeast Asia based on the reports from Japan, 19 Singapore, 20 and Vietnam, 21 the prevalence in these areas is either low or unknown. Furthermore, there are no formal reports on CeD from Taiwan, Indonesia, Korea, and many other Asian countries.…”

Section: Introductionmentioning

confidence: 99%

Opportunities and challenges in the management of celiac disease in Asia

et al. 2020

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Although once considered uncommon, there is increasing recognition of celiac disease (CeD) in Asia. It is now clear that CeD is a disorder as frequent in certain Asian countries as that in western countries, although it often remains undiagnosed. With increasing awareness and diagnosis, the absolute numbers of celiac patients are expected to increase markedly in Asia. Asia, with 60% of the population of the world, is probably the major "reservoir" of undiagnosed CeD in the world. As Asia has a huge landscape along with highly heterogenous genetic, social, cultural, and nutritional practices, similar heterogeneity is seen in the epidemiology, diagnostic, and therapeutic facilities for CeD in Asia. In this article, we have reviewed the changes in the epidemiology, diagnostics, and management of CeD in Asia and summarized the challenges and opportunities for its emergence in Asia.

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“…Nevertheless, in some Asian nations, CD is still considered to be either non-existent or very rare, but the incidence may be underestimated due to a lack of awareness and low suspicion of the disease [49]. In particular, official reports on CD prevalence in the paediatric Japanese population are absent, but among non-clinical adults the prevalence is about 0.05% [50]. …”

Section: Screening Strategies In Paediatric Populationsmentioning

confidence: 99%

Current Paediatric Coeliac Disease Screening Strategies and Relevance of Questionnaire Survey

Savvateeva

Erdes

Antishin

et al. 2018

Int Arch Allergy Immunol

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Coeliac disease (CD) is an autoimmune enteropathy triggered by the ingestion of gluten-containing grains in genetically predisposed individuals. Identification of CD in clinical practice is often difficult due to the manifestation of non-specific symptoms and signs, so a relatively significant proportion of CD cases remain undiagnosed. Timely detection of the disease is necessary to provide an appropriate approach to control of the disease treatment, in order to avoid potential complications. This is even more important in the case of children and adolescents, to ensure their proper growth and development. In this review, we discuss the data on the current strategies for CD detection among paediatric populations and the role of questionnaire-based discovery of CD cases in the area of interest. We assume that mass screening is a preferable strategy for finding CD cases within the paediatric population because this could uncover symptomatic, oligosymptomatic, and asymptomatic CD cases. However, under conditions of limited financial resources, screening for CD in risk groups, members of which can be identified using questionnaires, is essential. The pros and cons of CD screening in paediatric populations are presented. These depend on a number of situational criteria (cost-effectiveness, lack of awareness), but screening is designed to improve the detection of the disease and therefore improve the quality of life of patients.

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Celiac disease in non-clinical populations of Japan

Abstract: The presence of celiac disease in a non-clinical Japanese population was low at 0.05% and was rarely found in patients with unexplained chronic abdominal symptoms.

Cited by 53 publications

References 38 publications

An Overview of Celiac Disease in Childhood Type 1 Diabetes

An Overview of Celiac Disease in Childhood Type 1 Diabetes

Opportunities and challenges in the management of celiac disease in Asia

Current Paediatric Coeliac Disease Screening Strategies and Relevance of Questionnaire Survey

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