Celiac disease in patients with systemic lupus erythematosus

Soltani, Zahra; Baghdadi, Azarakhsh; Nejadhosseinian, Mohammad; Faezi, Seyedeh Tahereh; Shahbazkhani, Bijan; Mousavi, Seyed Ali; Kazemi, Kiarash

doi:10.5114/reum.2021.105416

Cited by 13 publications

(20 citation statements)

References 29 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…An Israelian study based on a large medical database compared 5,018 patients with SLE and 25,090 age-and sex-matched controls and reported an association between SLE and CD with a multivariate OR of 3.92 [51]. Conversely, other studies found no association between SLE and CD [52,53] Very recently, a study by Soltani et al, including both adults and children (without any specific age-related analysis), reported a prevalence of 3% for biopsy-proven CD in patients with SLE and, thus, revamped this issue [54].…”

Section: Pediatric Systemic Lupus Erythematosus and Celiac Diseasementioning

confidence: 99%

Celiac Disease in Juvenile Idiopathic Arthritis and Other Pediatric Rheumatic Disorders

Poddighe

Romano

Dossybayeva

et al. 2022

JCM

View full text Add to dashboard Cite

Celiac Disease (CD) is an immune-mediated and gluten-related disorder whose prevalence is higher in children affected with other autoimmune disorders, including diabetes mellitus type 1, autoimmune thyroiditis, and others. As regards Juvenile Idiopathic Arthritis (JIA) and other pediatric rheumatic disorders, there is no clear recommendation for CD serological screening. In this review, we analyze all the available clinical studies investigating CD among children with JIA (and other rheumatic diseases), in order to provide objective data to better understand the necessity of CD serological screening during the follow-up. Based on the present literature review and analysis, >2.5% patients with JIA were diagnosed with CD; however, the CD prevalence in JIA patients may be even higher (>3–3.5%) due to several study limitations that could have underestimated CD diagnosis to a variable extent. Therefore, serological screening for CD in children affected with JIA could be recommended due to the increased CD prevalence in these patients (compared to the general pediatric population), and because these JIA patients diagnosed with CD were mostly asymptomatic. However, further research is needed to establish a cost-effective approach in terms of CD screening frequency and modalities during the follow-up for JIA patients. Conversely, at the moment, there is no evidence supporting a periodical CD screening in children affected with other rheumatic diseases (including pediatric systemic lupus erythematosus, juvenile dermatomyositis, and systemic sclerosis).

show abstract

Section: Pediatric Systemic Lupus Erythematosus and Celiac Diseasementioning

confidence: 99%

Celiac Disease in Juvenile Idiopathic Arthritis and Other Pediatric Rheumatic Disorders

Poddighe

Romano

Dossybayeva

et al. 2022

JCM

View full text Add to dashboard Cite

show abstract

“…22 In contrast, biopsy proven-celiac disease prevalence in SLE patients is reported to be around 3%. 23 Interestingly, celiac disease might be diagnosed several years before SLE diagnosis, as reported in another study. 24 All these associations (IBD and SLE or celiac disease and SLE) show that there is a combination of many factors (genetic predispositions, environmental impact, diet, immunological disorders) that can explain the coexistence of these diseases.…”

Section: Sle and Celiac Diseasementioning

confidence: 66%

Section: Digestive Disorders In Slementioning

confidence: 66%

Intestinal involvement in lupus: From pathophysiology to therapeutic perspectives

Carlé

Mas

Barreau

2023

Lupus

View full text Add to dashboard Cite

Lupus erythematosus is a complex autoimmune disease characterized by skin and/or systemic involvement. Among systemic disorders, half of the patients will experience non-specific digestive symptoms, usually due to drug medication or transitory infections. In rare cases, lupus enteritis can be observed, and its diagnosis may precede the disease and/or be associated with an inflammatory bowel disease (IBD). Among the underlying mechanisms explaining the digestive damages observed in systemic lupus erythematosus (SLE) and the intestinal barrier function (IBF), increased intestinal permeability, microbiota dysbiosis, and intestinal immune system dysregulations are described in numerous murine and human studies. New therapeutic approaches in addition to conventional treatments are evoked in order to better control the IBF disruption and maybe prevent the onset or worsening of the disease. Thus, the aims of this review are to present the alterations of the digestive tract in SLE patients and the link between SLE and IBD as well as how the different elements of the IBF could participate in SLE pathogenesis.

show abstract

“…Based on isolated case reports, some authors have suggested that ocular manifestations might be a presenting symptom of SLE [ 1 , 3 , 5 , 13 , 17 , 20 ]. As stated previously, the literature on the subject is limited to patients already being treated for SLE, and therefore this conclusion is not backed by evidence.…”

Section: Discussionmentioning

confidence: 99%

Retinopathy in newly-diagnosed systemic lupus erythematosus: should we screen for ocular involvement?

et al. 2021

Self Cite

View full text Add to dashboard Cite

Background Ocular manifestations are common in systemic lupus erythematosus (SLE). Retinopathy has previously been linked to disease severity and might have a significant impact on the patient’s quality of life and has also been associated with a poor prognosis in SLE. This study aimed to determine the prevalence of retinopathy among patients who are newly diagnosed with SLE. Methods In a cross-sectional study, patients diagnosed with SLE at a tertiary referral clinic were assessed for inclusion between March 2016 and March 2017. Patients who had received treatment for SLE at any time were excluded, as well as patients with hypertension, diabetes mellitus, and coagulopathy. Clinical findings and laboratory test results were recorded, and patients were examined by an ophthalmologist for evidence of retinal pathologies. SLE disease activity index was also calculated for all patients. Results With 114 patients included in the final analysis, we found a prevalence of 15.8% for retinopathy among newly-diagnosed SLE patients. Cotton-wool spots were the most common finding (78%). Patients with retinopathy had significantly lower hemoglobin levels, C3 and C4 concentrations, and higher ANA and Anti-dsDNA levels. Also, patients with retinopathy had a significantly higher SLE DAI score. Conclusions We found a relatively high rate of retinopathy in SLE patients at the time of their initial diagnosis. Our findings suggest that retinopathy is an early manifestation of the disease. Ophthalmologic screening might be considered for SLE patients at the time of diagnosis, especially for those with severe disease. We also encourage researchers to further evaluate the correlation between retinopathy and disease activity, and the prognosis of ocular involvement.

show abstract

Celiac disease in patients with systemic lupus erythematosus

Cited by 13 publications

References 29 publications

Celiac Disease in Juvenile Idiopathic Arthritis and Other Pediatric Rheumatic Disorders

Celiac Disease in Juvenile Idiopathic Arthritis and Other Pediatric Rheumatic Disorders

Intestinal involvement in lupus: From pathophysiology to therapeutic perspectives

Retinopathy in newly-diagnosed systemic lupus erythematosus: should we screen for ocular involvement?

Contact Info

Product

Resources

About