Celiac disease prevalence in a large series of patients with Behçet's disease

Koçak, Erdem; Akbal, Erdem; Beyazıt, Yavuz; Ergül, Bilal; Karataş, Arzu; Köklü, Seyfettin; Ekşioğlu, Hatice Meral

doi:10.1111/1756-185x.12990

Cited by 6 publications

(6 citation statements)

References 27 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…15 In a Turkish study, 25% of patients had UGI symptoms, but only 0.5% had esophageal ulcers, 1.6% had gastric ulcers, and 2.1% had duodenal ulcers. 16 In our study, 23.8% (24/101) of the patients had symptoms, and 18.8% of the patients had UGI involvement. The prevalence of UGI involvement in BD patients may differ regionally, and it may be associated with the prevalence of intestinal BD.…”

Section: Discussionsupporting

confidence: 45%

“…A recent Korean study of patients with GI symptoms documented UGI involvement in 27.9% (36/129) of patients 15 . In a Turkish study, 25% of patients had UGI symptoms, but only 0.5% had esophageal ulcers, 1.6% had gastric ulcers, and 2.1% had duodenal ulcers 16 . In our study, 23.8% (24/101) of the patients had symptoms, and 18.8% of the patients had UGI involvement.…”

Section: Discussionmentioning

confidence: 94%

See 1 more Smart Citation

Upper gastrointestinal involvement of Behçet's disease in Japan: endoscopic findings and clinical features

Murakami,

Arai,

Ihara

et al. 2024

J of Gastro and Hepatol

View full text Add to dashboard Cite

AimBehçet's disease (BD) can involve any gastrointestinal (GI) tract site. We analyzed the characteristics, risk factors, and treatment responses to upper GI (UGI) involvement in patients with BD.MethodsThis retrospective cohort study analyzed UGI findings in 101 patients with BD who underwent endoscopy between April 2005 and December 2022 at the University of Tokyo Hospital. The patients were divided into two groups based on the presence or absence of UGI findings. Patient backgrounds, clinical symptoms, colonoscopy (CS) findings, and blood test findings were compared between the groups.ResultsIn total, 18.8% (19/101) of the patients had UGI lesions. The prevalence rates in the esophagus, stomach, and duodenum were 6.9%, 6.9%, and 8.9%, respectively. Of these 19 patients, BD treatment were intensified in 10 (52.6%) patients after esophagogastroduodenoscopy (EGD), and all showed improvement in symptoms or endoscopic findings. In the multivariate analysis, symptoms (OR: 37.1, P < 0.001), CRP > 1 mg/dL (OR: 11.0, P = 0.01), and CS findings (OR: 5.16, P = 0.04) were independent predictors of UGI involvement in BD patients. The prediction model for UGI involvement using these three factors was highly accurate, with an AUC of 0.899 on the ROC curve. In the subgroup analysis of intestinal BD, symptoms (OR: 12.8, P = 0.01) and ESR > 20 mm/h (OR: 11.5, P = 0.007) were independent predictors.ConclusionsEGD should be conducted in BD patients with high CRP, GI symptoms, and lower GI involvement, which leads to better management of BD in terms of improving symptoms and endoscopic findings.

show abstract

Section: Discussionsupporting

confidence: 45%

Section: Discussionmentioning

confidence: 94%

Upper gastrointestinal involvement of Behçet's disease in Japan: endoscopic findings and clinical features

Murakami,

Arai,

Ihara

et al. 2024

J of Gastro and Hepatol

View full text Add to dashboard Cite

show abstract

“…Taking into account the patient's origin, an alternative explanation for thrombosis in this patient was considered. Behçet disease is described to be linked to celiac disease and shares a number of characteristics with CD [33]. However, since our patient had no history of oral or genital ulcers and no history of uveitis or visual complaints, a diagnosis of Behçet disease remains unlikely.…”

Section: Central Nervous System Vasculitis Associated With CDmentioning

confidence: 79%

Concurrent cerebral arterial and venous sinus thrombosis revealing celiac disease- a case report and literature review

Alhosain

Kouba

2020

BMC Gastroenterol

View full text Add to dashboard Cite

Background Celiac disease is an autoimmune condition characterized by an inappropriate immune reaction against gluten. It classically presents as chronic diarrhea, bloating, and nausea in addition to malabsorption symptoms such as weight loss and micronutrient deficiency. We report the first case of coinciding cerebral infarction and venous sinus thrombosis unveiling the diagnosis of celiac disease. Case presentation A 40-year old female patient with a four-day history of severe diarrhea presented with right hemiplegia and altered mental status. Imaging revealed left middle cerebral artery occlusion and left transverse and sigmoid venous sinus thrombosis, along with left jugular vein thrombosis. Her laboratory evaluation was notable for profound iron deficiency anemia, thrombocytosis, and hyperhomocysteinemia. Her positive anti-tissue transglutaminase IgA antibodies and ensuing duodenal biopsy confirmed the diagnosis of celiac disease. Conclusions Celiac disease has a wide range of intestinal and extraintestinal manifestations and can present with thrombotic events in young patients with iron deficiency and hyperhomocysteinemia.

show abstract

“…Taking into account the patient's origin, an alternative explanation for thrombosis in this patient was considered. Behçet disease is described to be linked to celiac disease and shares a number of characteristics with CD [34]. However, since our patient had no history of oral or genital ulcers and no history of uveitis or visual complaints, a diagnosis of Behçet disease remains unlikely.…”

Section: C) Central Nervous System Vasculitis Associated With CDmentioning

confidence: 79%

Concurrent cerebral arterial and venous sinus thrombosis revealing celiac disease - A case report and literature review

Alhosain

Kouba

2020

Preprint

View full text Add to dashboard Cite

Background: Celiac disease is an autoimmune condition characterized by an inappropriate immune reaction against gluten. It classically presents as chronic diarrhea, bloating, and nausea in addition to malabsorption symptoms such as weight loss and micronutrient deficiency. We report the first case of coinciding cerebral infarction and venous sinus thrombosis unveiling the diagnosis of celiac disease.Case Presentation: A 40-year old female patient with a four-day history of severe diarrhea presented with right hemiplegia and altered mental status. Imaging revealed left middle cerebral artery occlusion and left transverse and sigmoid venous sinus thrombosis, along with left jugular vein thrombosis. Her laboratory evaluation was notable for profound iron deficiency anemia, thrombocytosis, and hyperhomocysteinemia. Her positive anti-tissue transglutaminase IgA antibodies and ensuing duodenal biopsy confirmed the diagnosis of celiac disease.Conclusions: Celiac disease has a wide range of intestinal and extra-intestinal manifestations and can present with thrombotic events in young patients with iron deficiency and hyperhomocysteinemia.

show abstract

Celiac disease prevalence in a large series of patients with Behçet's disease

Abstract: Although BD and CD share many similar clinical manifestations, our results did not support a possible association between these two diseases.

Cited by 6 publications

References 27 publications

Upper gastrointestinal involvement of Behçet's disease in Japan: endoscopic findings and clinical features

Upper gastrointestinal involvement of Behçet's disease in Japan: endoscopic findings and clinical features

Concurrent cerebral arterial and venous sinus thrombosis revealing celiac disease- a case report and literature review

Concurrent cerebral arterial and venous sinus thrombosis revealing celiac disease - A case report and literature review

Contact Info

Product

Resources

About