Celiac Disease Symptom Resolution

Sansotta, Naire; Amirikian, Karine; Guandalini, Stefano; Jericho, Hilary

doi:10.1097/mpg.0000000000001634

Cited by 82 publications

(65 citation statements)

References 23 publications

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“…The most frequently described deficiencies in CD patients at diagnosis are of iron, vitamin D, calcium, vitamin B12, folic acid and zinc. Presence of iron deficiency was described in 6%-82% of adult patients and in 12%-82% of pediatric patients newly diagnosed with CD [15][16][17][18][19][20][21][22][23][37][38][39]. Iron status has been well researched in regard to CD and the results presented here were obtained from twelve different study populations.…”

Section: Nutritional Deficiencies At Moment Of Diagnosis In Untreatedmentioning

confidence: 90%

“…Strikingly, little evidence is available on the prevalence of iron deficiency in pediatric patients on a GFD and even less on the potential clinical implications in this regard. This should be given more attention, considering that iron deficiency anemia (IDA) is one of the most prevalent extra-intestinal manifestations of CD at diagnosis [21,38,55]. Adherence to a GFD does appear to reduce the prevalence and severity of IDA and increases serum iron and ferritin, although repletion of iron stores may take a prolonged time after healing of the intestinal mucosa [17,24,43,51,56,57].…”

Section: Nutritional Deficiencies While On a Gluten-free Diet In Treamentioning

confidence: 99%

“…These, symptoms and comorbidities can serve as indicators for nutrient deficiencies in the long and short term. IDA is one of the most prevalent extra-intestinal manifestations of CD at diagnosis [21,55]. IDA can cause symptoms associated with CD such as fatigue, headaches and decreased exercise tolerance.…”

Section: Comorbidities Potentially Related To Nutrient Deficiencies Imentioning

confidence: 99%

“…Anemia in CD has further shown to be associated with greater disease severity and slower histological recovery in response to the GFD [63][64][65]. IDA is one of the most prevalent extra-intestinal manifestations of CD at diagnosis [21,55]. IDA can cause symptoms associated with CD such as fatigue, headaches and decreased exercise tolerance.…”

Section: Comorbidities Potentially Related To Nutrient Deficiencies Imentioning

confidence: 99%

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Narrative Review: Nutrient Deficiencies in Adults and Children with Treated and Untreated Celiac Disease

et al. 2020

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Nutrient deficiencies are well recognized as secondary consequences of celiac disease (CD) and closely related to the clinical presentation of affected patients. Despite their clinical significance, consensus is lacking on the pattern and frequency of nutrient deficiencies in CD, the usefulness of their assessment at the time of diagnosis and during follow-up. This review aims to provide an overview of nutrient deficiencies among pediatric and adult CD patients at diagnosis and on a gluten-free diet (GFD), and their potential causes in CD. Secondly, we review their impact on CD management strategies including the potential of nutrient supplementation. A search of Medline, Pubmed and Embase until January 2019 was performed. Despite a high variability between the reported deficiencies, we noted that nutrient deficiencies occur frequently in children and adults with CD at diagnosis and during treatment with a GFD. Both inadequate dietary intake and/or diminished uptake due to intestinal dysfunction contribute to nutrient deficiencies. Most deficiencies can be restored with (long-term) treatment with a GFD and/or supplementation. However, some of them persist while others may become even more prominent during GFD. Our results indicate a lack of comprehensive evidence on the clinical efficacy of nutrient supplementation in CD management highlighting the need for further studies.

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Section: Nutritional Deficiencies At Moment Of Diagnosis In Untreatedmentioning

confidence: 90%

Section: Nutritional Deficiencies While On a Gluten-free Diet In Treamentioning

confidence: 99%

Section: Comorbidities Potentially Related To Nutrient Deficiencies Imentioning

confidence: 99%

Section: Comorbidities Potentially Related To Nutrient Deficiencies Imentioning

confidence: 99%

See 2 more Smart Citations

Narrative Review: Nutrient Deficiencies in Adults and Children with Treated and Untreated Celiac Disease

et al. 2020

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“…Researchers agree that strict adherence to the gluten-free diet offers the greatest relief of symptoms for most patients with CD [ 151 , 152 , 153 , 154 , 155 ]. However, symptom recovery rates differ across age and gender [ 151 , 152 , 153 , 154 ]. It is also worth noting that diagnostic delays over 5 years may worsen recovery rates on a gluten-free diet [ 151 ].…”

Section: Gluten-related Disordersmentioning

confidence: 99%

A Review on the Gluten-Free Diet: Technological and Nutritional Challenges

2018

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Consumers, food manufacturers and health professionals are uniquely influenced by the growing popularity of the gluten-free diet. Consumer expectations have urged the food industry to continuously adjust and improve the formulations and processing techniques used in gluten-free product manufacturing. Health experts have been interested in the nutritional adequacy of the diet, as well as its effectiveness in managing gluten-related disorders and other conditions. In this review, we aim to provide a clear picture of the current motivations behind the use of gluten-free diets, as well as the technological and nutritional challenges of the diet as a whole. Alternative starches and flours, hydrocolloids, and fiber sources were found to play a complex role in mimicking the functional and sensory effects of gluten in gluten-free products. However, the quality of gluten-free alternatives is often still inferior to the gluten-containing products. Furthermore, the gluten-free diet has demonstrated benefits in managing some gluten-related disorders, though nutritional imbalances have been reported. As there is limited evidence supporting the use of the gluten-free diet beyond its role in managing gluten-related disorders, consumers are urged to be mindful of the sensorial limitations and nutritional inadequacies of the diet despite ongoing strategies to improve them.

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Fatigue in celiac disease: A review of the literature

2019

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Fatigue is increasingly recognized as a significant problem in patients with chronic inflammatory and autoimmune diseases. In celiac disease, a chronic immune‐mediated disease triggered by dietary gluten, conflicting opinions exist regarding both the size of the problem and the effect of a gluten‐free diet (GFD) on fatigue. We reviewed the existing literature regarding fatigue in celiac disease. We conducted a systematic search in the Embase, Ovid Medline, and Cochrane databases using subject terms from controlled vocabularies. Articles were reviewed based on language, type of article, title, and abstract or full text. Eighteen articles were finally selected for review. Fatigue was significantly greater in patients with celiac disease compared to healthy control subjects. Fatigue prevalence ranged from 8 to 100%. Fatigue severity was assessed in six studies. The fatigue visual analogue scale was the most frequently used fatigue instrument with scores from 57 to 79 prior to starting a GFD and from 39 to 59 in patients on a GFD. Seven studies investigated the effect of a GFD on fatigue, including five studies that reported less fatigue while on the diet and two studies that showed no significant difference. This review concludes that fatigue is a substantial complaint in patients with celiac disease. A GFD seems to reduce fatigue, but existing data are limited.

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Celiac Disease Symptom Resolution

Abstract: On a strict GFD, children report greater rates of both GI and EI symptom resolution as compared to adults with greater rates of improvement in GI over EI symptoms. Early recognition of CeD and close attention to diet adherence may help in symptom resolution.

Cited by 82 publications

References 23 publications

Narrative Review: Nutrient Deficiencies in Adults and Children with Treated and Untreated Celiac Disease

Narrative Review: Nutrient Deficiencies in Adults and Children with Treated and Untreated Celiac Disease

A Review on the Gluten-Free Diet: Technological and Nutritional Challenges

Fatigue in celiac disease: A review of the literature

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