Celiac disease: the search for adjunctive or alternative therapies

Hassan, Kareem; A-Kader, H. Hesham

doi:10.1586/17474124.2014.882769

Cited by 5 publications

(4 citation statements)

References 76 publications

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“…The current available treatment for celiac disease is life-long gluten-free diet[91-93]. Generally clinical improvement is achieved within a few weeks and the mucosal damage recovers in 1-2 years[16].…”

Section: Current Treatments Of Celiac Diseasementioning

confidence: 99%

Celiac disease: From pathophysiology to treatment

Parzanese

Qehajaj

Patrinicola

et al. 2017

WJGP

220

169

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Celiac disease, also known as “celiac sprue”, is a chronic inflammatory disorder of the small intestine, produced by the ingestion of dietary gluten products in susceptible people. It is a multifactorial disease, including genetic and environmental factors. Environmental trigger is represented by gluten while the genetic predisposition has been identified in the major histocompatibility complex region. Celiac disease is not a rare disorder like previously thought, with a global prevalence around 1%. The reason of its under-recognition is mainly referable to the fact that about half of affected people do not have the classic gastrointestinal symptoms, but they present nonspecific manifestations of nutritional deficiency or have no symptoms at all. Here we review the most recent data concerning epidemiology, pathogenesis, clinical presentation, available diagnostic tests and therapeutic management of celiac disease.

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Section: Current Treatments Of Celiac Diseasementioning

confidence: 99%

Celiac disease: From pathophysiology to treatment

Parzanese

Qehajaj

Patrinicola

et al. 2017

WJGP

220

169

View full text Add to dashboard Cite

show abstract

“…The current available treatment for CD is lifelong gluten-free diet (GFD) with which clinical improvement is achieved within a few weeks and the mucosal damage recovers in 1--2 years. [ 7 8 ] Primary care physicians who are generally first to be contacted should have detailed knowledge of CD as it is one of the most diversely presenting conditions. Early diagnosis and treatment by them are fundamental in pediatric celiac disease particularly as some of the complications are irreversible such as growth retardation, abnormal dentition, osteoporosis, etc.…”

Section: Introductionmentioning

confidence: 99%

Study of effect of gluten-free diet on vitamin D levels and bone mineral density in celiac disease patients

Verma

Lata

Khanna

et al. 2022

Journal of Family Medicine and Primary Care

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Objective: Celiac disease (CD) is a multifactorial immune-mediated enteropathy caused by a response to ingested gluten. The current available treatment for CD is lifelong gluten-free diet (GFD). This study was done to see the effect of GFD on Vitamin D levels and bone mass density in celiac patients. Methods: A prospective interventional study on newly diagnosed celiac patients was conducted in the Pediatrics department of a tertiary care teaching institute in 2 stages viz. on presentation and after 6 months of GFD. Anthropometric measurements, biochemical investigations, Vitamin D levels, and DEXA scan was done at recruitment and after 6 months of GFD and was analyzed. Results: In newly diagnosed 60 pediatric celiac patients, positive effect of GFD on anthropometry, hemoglobin, Vitamin D levels, DEXA scan parameters was observed. Significant difference was found in Vitamin D levels which increased from baseline 14.85 ± 5.39 to 18.22 ± 5.67 ng/ml after 6 months of GFD ( P < 0.05). Significant difference was found in BMD (mean Z-score) which increased from -0.941 ± 0.738 to -0.640 ± 0.60 after 6 months of GFD ( P < 0.001). Conclusion: Our study concluded that there is significant increase in vitamin D levels as well as Z-score, bone mass density (BMD) and bone Mass Content (BMC) after 6 months of GFD.

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“…10,11 The elimination of gluten from the diet (gluten free diet) intake is the main therapeutic approach and usually leads to symptomatic, serologic, and histological remission. 12,13 Dietary history assessment and measurement of serum antibodies are two non-invasive means of compliance measurement while invasive ways include endoscopic and histologic criteria. The barrier to compliance includes the poor portability of gluten-free foods, confusing food labelling practices, and common co-morbid psychological burdens such as anxiety and depression.…”

Section: Introductionmentioning

confidence: 99%

The effect of gluten-free diet on mean platelet volume levels as a short-term follow up biomarker in biopsy proven celiac disease patients and its comparison with IgA-tissue transglutaminase antibody levels

Gogra,

Beniwal,

Patel

et al. 2023

Int J Contemp Pediatr

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Background: Celiac disease is an autoimmune disease for which there is a known environmental trigger i.e., gluten. Adherence to gluten-free diet is the mainstay of treatment. Methods: This observational prospective study was conducted in the Department of Paediatrics, SP Medical College, Bikaner between August 2020 to August 2021. Newly diagnosed celiac disease patients below 14 years of age were included in the study excluding patients with any associated co-morbid conditions like Diabetes, Hypertension and Hypothyroidism. IgA-tTG titre and complete blood counts were performed at the time of diagnosis, and repeated after 3 months of strict gluten-free diet. The collected data were coded, tabulated and analysed. P values < 0.05 were statistically significant. Results: The mean IgA-tTG decreased from 116.28 at the time of diagnosis to 50.98 after 3 months of the gluten-free diet (p = <0.001). Also, the mean MPV decreased from 9.58 to 9.19 and the change was statistically significant (p = 0.032). When two biomarkers i.e., MPV and IgA-tTG were compared as being better biomarkers for the gluten-free diet, a weak positive correlation was observed but was not statistically significant (p = 0.212). Conclusions: This study showed that Mean Platelet Volume (MPV) levels can be used as a short-term biomarker to check adherence to the gluten-free diet.

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Celiac disease: the search for adjunctive or alternative therapies

Cited by 5 publications

References 76 publications

Celiac disease: From pathophysiology to treatment

Celiac disease: From pathophysiology to treatment

Study of effect of gluten-free diet on vitamin D levels and bone mineral density in celiac disease patients

The effect of gluten-free diet on mean platelet volume levels as a short-term follow up biomarker in biopsy proven celiac disease patients and its comparison with IgA-tissue transglutaminase antibody levels

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