Cell adhesion and growth on surfaces modified by plasma and ion implantation

Araujo, W. W. R.; Teixeira, F. S.; Silva, Glenda Nicioli da; Salvadori, Daisy Maria Fávero; Salvadori, M. C.

doi:10.1063/1.4871541

Cited by 4 publications

(1 citation statement)

References 47 publications

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“…, boiling in strong acid), or electrochemical oxidation. , Oxygen-functionalized surfaces usually have lower energy levels relative to the vacuum level. Along with these interesting features, oxygen-functionalized surfaces develop hydrophilic properties. ,, In addition, oxygen functionalized surfaces reportedly enhance cell attachment and create a favorable environment for cell growth and biological interaction. − As such, oxygen functionalization allows controlling the material surface wettability and consequently enhancing its biocompatibility which is favorable in implant engineering. Moreover, surface treatment such as oxygen plasma results in faster etching of sp 2 graphitic impurities and exposing the rich sp 3 surface of the material .…”

Section: Introductionmentioning

confidence: 99%

Single-Step Fabrication Method toward 3D Printing Composite Diamond–Titanium Interfaces for Neural Applications

Mani

Ahnood

Peng

et al. 2021

ACS Appl. Mater. Interfaces

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Owing to several key attributes, diamond is an attractive candidate material for neural interfacing electrodes. The emergence of additivemanufacturing (AM) of diamond-based materials has addressed multiple challenges associated with the fabrication of diamond electrodes using the conventional chemical vapor deposition (CVD) approach. Unlike the CVD approach, AM methods have enabled the deposition of three-dimensional diamond-based material at room temperature. This work demonstrates the feasibility of using laser metal deposition to fabricate diamond−titanium hybrid electrodes for neuronal interfacing. In addition to exhibiting a high electrochemical capacitance of 1.1 mF cm −2 and a low electrochemical impedance of 1 kΩ cm 2 at 1 kHz in physiological saline, these electrodes exhibit a high degree of biocompatibility assessed in vitro using cortical neurons. Furthermore, surface characterization methods show the presence of an oxygenrich mixed-phase diamond−titanium surface along the grain boundaries. Overall, we demonstrated that our unique approach facilitates printing biocompatible titanium−diamond site-specific coating-free conductive hybrid surfaces using AM, which paves the way to printing customized electrodes and interfacing implantable medical devices.

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